Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2267377..2268942 Replicon chromosome
Accession NZ_CP087280
Organism Leclercia adecarboxylata strain SH19PE29

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LO739_RS10785 Protein ID WP_117386531.1
Coordinates 2267377..2268687 (-) Length 437 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LO739_RS10790 Protein ID WP_032618098.1
Coordinates 2268691..2268942 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO739_RS10770 (LO739_10770) 2262858..2264039 - 1182 WP_230431479.1 PLP-dependent aminotransferase family protein -
LO739_RS10775 (LO739_10775) 2264172..2266169 - 1998 WP_117386533.1 TonB-dependent receptor -
LO739_RS10780 (LO739_10780) 2266180..2267241 - 1062 WP_230431480.1 YncE family protein -
LO739_RS10785 (LO739_10785) 2267377..2268687 - 1311 WP_117386531.1 type II toxin-antitoxin system HipA family toxin Toxin
LO739_RS10790 (LO739_10790) 2268691..2268942 - 252 WP_032618098.1 helix-turn-helix domain-containing protein Antitoxin
LO739_RS10795 (LO739_10795) 2269740..2273540 + 3801 WP_230431481.1 glycosyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 437 a.a.        Molecular weight: 48182.33 Da        Isoelectric Point: 6.5044

>T225198 WP_117386531.1 NZ_CP087280:c2268687-2267377 [Leclercia adecarboxylata]
MRAQRLTVAMNGDVVGTLHRDGSGAMSFQYAPEWLAEPGSRAISLSLPLQHGRIRGAQVFNFFSNLLPDSEAIIARMQAR
FQVETAHPFDLLASVGRDCVGAIQLYPPGQEIPPVTDIVAEPLDDDQIAALLDGYQMAPLGMTEEDADFRISLAGAQEKT
ALLWYQARWQRPQGSTPTSHIFKLPIGRIEQNNIDLSESCENEWLCLRIAKAFGFPVAQAEMATFGRKKVLIIERFDRRW
SSSGWLMRLPQEDFCQALGVSPALKYESHGGPGIADAMKLLLGSRLAGQDRELFFKAQILFWMLAAIDGHGKNFSLFIEA
DSAFRMAPLYDVISAFPLFDAGGIPVKKAKMAMALQGKNRQYHFAMIQPRHFISTAAFAGYSQEAARRLLAEMAERTDDV
IASVRAELPPDFPAQVSEAIFKGLASQAARIGRFVS

Download         Length: 1311 bp

>T225198 NZ_CP121071:50117-50422 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTACCGCCTGTTTGTGGATGTGCAGAGCGACATCGTCGATAC
CCCTGGCCGGCGAATGGTGATCCCGCTGGCCAGTGCCCGTCTGCTGTCGGATAAGGTCTCCCGCGAACTTTATCCGGTGG
TGCATATCGGGGATGAGAGCTGGCGTCTGATGACCACGGATATGGCCAGTGTCCCGGCCTCATTCATCGGGGAAGAGGTG
GCCGAGCTCAGCCACAGGGAGAACGACATCAAAAACGCCATTAACCTGATGTTCTGGGGGATCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9223.56 Da        Isoelectric Point: 10.1945

>AT225198 WP_032618098.1 NZ_CP087280:c2268942-2268691 [Leclercia adecarboxylata]
MKVTSADALAQAVRDQRKVNKLTQTATAEQVGIKQTTVSEFENKPGSTKLETLFKILSALDLELHVVKRGGTLPDNNAWK
KEW

Download         Length: 252 bp

>AT225198 NZ_CP121071:49897-50115 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAAGCAGCGTATTACTGTCACCATAGACAGTGACAGCTATCAGTTACTCAAGTCCGCAGACGTGAATATCTCCGGCCT
GGTAAATACTGCCATGCAGAAGGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAGCGAACGGCTCCTTTGCAGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References