Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1107444..1108063 Replicon chromosome
Accession NZ_CP087280
Organism Leclercia adecarboxylata strain SH19PE29

Toxin (Protein)


Gene name Hha Uniprot ID A0A345CDT0
Locus tag LO739_RS05245 Protein ID WP_032616864.1
Coordinates 1107444..1107662 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A3E1ZZ82
Locus tag LO739_RS05250 Protein ID WP_032616865.1
Coordinates 1107671..1108063 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO739_RS05225 (LO739_05225) 1104288..1104641 + 354 WP_059308601.1 DUF1428 family protein -
LO739_RS05230 (LO739_05230) 1104674..1106242 - 1569 WP_130589227.1 EAL domain-containing protein -
LO739_RS05235 (LO739_05235) 1106508..1106648 + 141 WP_032616862.1 type B 50S ribosomal protein L36 -
LO739_RS05240 (LO739_05240) 1106708..1107172 - 465 WP_032616863.1 YlaC family protein -
LO739_RS05245 (LO739_05245) 1107444..1107662 - 219 WP_032616864.1 HHA domain-containing protein Toxin
LO739_RS05250 (LO739_05250) 1107671..1108063 - 393 WP_032616865.1 Hha toxicity modulator TomB Antitoxin
LO739_RS05255 (LO739_05255) 1108554..1111694 - 3141 WP_117385933.1 multidrug efflux RND transporter permease subunit AcrB -
LO739_RS05260 (LO739_05260) 1111717..1112910 - 1194 WP_032616867.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1097177..1108063 10886


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T225196 WP_032616864.1 NZ_CP087280:c1107662-1107444 [Leclercia adecarboxylata]
MSDKPLTKTDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTAVWKFVR

Download         Length: 219 bp

>T225196 NZ_CP121071:28886-29368 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGAAATAAGTGTTACTGCACCGGAGTTGCTAAACGAGGAACACTATCTTCAACAGTTTGATTGCGGGAATGATGTGCT
CAGTGACTGGCTTCGCCGCAGAGCGATGAAGAACCAATACCTCAATGCCTCCCGTACATTTGTTATCTGCCCTGAAGGCA
CAAAGCGAGTAGTGGGATATTACTCTATTGCGACGGGGTCTGTAAGTCATGCCAGTTTAGGTCGCAGTTTACGCCAGAAT
ATGCCCGATCCTGTTCCGGTTGTTTTGCTGGGACGTCTTGCTGTTGATGAGTGTACTCAAGGGCATAGTTTTGGAAAATG
GCTGCTTAATGATGCTGTAACACGGGTATCTAACCTGGCAGACCAGGTGGGTATTAAAGCGATCATGGTTCATGCTATTG
ATGAACAGGCGAAAACATTCTATGAATACTTTGGCTTTGTTCAGTCTCCCATTGCGCCAAATACATTGTTCTACAAGATT
TAA

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15093.98 Da        Isoelectric Point: 4.8941

>AT225196 WP_032616865.1 NZ_CP087280:c1108063-1107671 [Leclercia adecarboxylata]
MDEYSPKRQDIAQLKFLCESLYHDCLSNLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNASKANPLASPVKIITNN

Download         Length: 393 bp

>AT225196 NZ_CP121071:28611-28895 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCAAACTACAATCCGCAAATCTGTGCGTAATAAACAAATAAATATACGGGCTACTGATGAGGAACGTGCTGTGATTGA
TTATGCAGCGAGCCTGGTCAGTAAAAACCGTACCGACTTCATCATAGAAAAGGCTGTGAGCGAGGCCCAGAATATCATTC
TGGATCAACGCGTTTTTGTTCTGGATGATGCCCGCTATCAGGCTTTTATTAAACAACTTGAAGCTCCTGTACAGAATACT
GAAGGTCGTCAGCGCCTGATGGATGTGAAACCTGAATGGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A345CDT0

Antitoxin

Source ID Structure
AlphaFold DB A0A3E1ZZ82

References