Detailed information of TA system TA225192

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1608371..1609027
• Replicon: chromosome
• Accession: NZ_CP087277
• Organism: Ralstonia solanacearum strain FJ1003

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LOH50_RS07495
• Protein ID: WP_082240000.1
• Coordinates: 1608371..1608556 (+)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0S4XBS4
• Locus tag: LOH50_RS07500
• Protein ID: WP_028853163.1
• Coordinates: 1608626..1609027 (+)
• Length: 134 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOH50_RS07475	1603404..1604057	-	654	WP_003267806.1	ATP-dependent Clp endopeptidase proteolytic subunit ClpP	-
LOH50_RS07480	1604087..1605436	-	1350	WP_011001651.1	trigger factor	-
LOH50_RS07485	1605691..1607664	-	1974	WP_071623776.1	bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC	-
LOH50_RS07490	1607736..1607930	-	195	WP_011001649.1	hypothetical protein	-
LOH50_RS07495	1608371..1608556	+	186	WP_082240000.1	type II toxin-antitoxin system HicA family toxin	Toxin
LOH50_RS07500	1608626..1609027	+	402	WP_028853163.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LOH50_RS07505	1609279..1610319	+	1041	WP_167801031.1	LysM domain-containing protein	-
LOH50_RS07510	1610803..1611681	-	879	WP_167801032.1	hypothetical protein	-
LOH50_RS07515	1611694..1612272	-	579	WP_162904219.1	D-alanyl-D-alanine carboxypeptidase family protein	-
LOH50_RS07520	1612815..1613174	-	360	WP_118891131.1	hypothetical protein	-
LOH50_RS07525	1613171..1613440	-	270	WP_118891130.1	hypothetical protein	-
LOH50_RS07530	1613446..1613754	-	309	WP_071508341.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1607736..1649772	42036

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6887.05 Da
• Isoelectric Point: 10.7125

>T225192 WP_082240000.1 NZ_CP087277:1608371-1608556 [Ralstonia solanacearum]
MQSAQLIRMLEDDGWQLVRVNGSHHHYKHPEKPGLLTVPHPKKDLPIGTVRSIQKKAAGLK

Nucleotide

• Length: 186 bp

>T225192 NZ_CP121070:c4183652-4183368 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAATTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTTGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin

Protein

• Length: 134 a.a.
• Molecular weight: 14752.56 Da
• Isoelectric Point: 4.4190

>AT225192 WP_028853163.1 NZ_CP087277:1608626-1609027 [Ralstonia solanacearum]
MQFPIAIHKDEGSVYGVTVPDIPGVHSWGDTIDDAVRNTREAIAGHLQTLVELGEDVDVTCSTIEDLTKQDEYAGAVWAL
IDVDAEELDRTPERINVSLPRFVLKKLDRFAENRHETRSGLLARAAMELMAHG

Nucleotide

• Length: 402 bp

>AT225192 NZ_CP121070:c4183884-4183642 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCCTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGAATTA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A0S4XBS4