Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1309779..1311374 Replicon chromosome
Accession NZ_CP087277
Organism Ralstonia solanacearum strain FJ1003

Toxin (Protein)


Gene name hipA Uniprot ID A0A0S4UDK5
Locus tag LOH50_RS06360 Protein ID WP_069079583.1
Coordinates 1309779..1311116 (-) Length 446 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0S4UDK3
Locus tag LOH50_RS06365 Protein ID WP_016725279.1
Coordinates 1311120..1311374 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOH50_RS06335 1305434..1306174 + 741 WP_011001390.1 protocatechuate 3,4-dioxygenase subunit beta -
LOH50_RS06340 1306171..1306869 + 699 WP_016725453.1 protocatechuate 3,4-dioxygenase subunit alpha -
LOH50_RS06345 1307017..1307613 + 597 WP_016725451.1 RNA 2',3'-cyclic phosphodiesterase -
LOH50_RS06350 1307626..1308354 - 729 WP_011001393.1 DsbA family protein -
LOH50_RS06355 1308580..1309782 - 1203 WP_064047701.1 MFS transporter -
LOH50_RS06360 1309779..1311116 - 1338 WP_069079583.1 type II toxin-antitoxin system HipA family toxin Toxin
LOH50_RS06365 1311120..1311374 - 255 WP_016725279.1 helix-turn-helix transcriptional regulator Antitoxin
LOH50_RS06370 1311478..1312317 - 840 WP_016725278.1 oxaloacetate decarboxylase -
LOH50_RS06375 1312635..1313273 + 639 WP_020831956.1 7-carboxy-7-deazaguanine synthase -
LOH50_RS06380 1313341..1313817 + 477 WP_011001399.1 6-carboxytetrahydropterin synthase QueD -
LOH50_RS06385 1313837..1314388 + 552 WP_016727233.1 tRNA adenosine(34) deaminase TadA -
LOH50_RS06390 1314385..1315311 + 927 WP_016727232.1 muramoyltetrapeptide carboxypeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-107)

Antitoxin

Transcription regulator, HipB-like

(10-66)


Sequences

Toxin        


Download         Length: 446 a.a.        Molecular weight: 48724.75 Da        Isoelectric Point: 6.7232

>T225191 WP_069079583.1 NZ_CP087277:c1311116-1309779 [Ralstonia solanacearum]
MAHPELHLWMNGEHVGIWTASRAGVPILRYDDGWLRSPNMRPLSLSLPIPAGVPELRGQVVDDYFDNLLPEAQPIRERVR
RRFGLASTDAAELLAAIGRDCVGAVQLLPPGMAPTGYDRIDSEPLTDSQVDTLLRNLTATPALGEDAGDPDAFRISIAGA
QEKTALLRIGDAWHRPLGATPTTHILKLPLGLIGNIRADMQDSVDNEWLCAQLLAAWGLEVARTEIARFGASKVLAVERF
DRRWMPGNAWIARLPQEDFCQATGTPAHRKYENDGGPGMRACLDLLSASEHAIDDKRRFVLAQLAFWLLAATDGHAKNFS
LAIGRGGRFRMTPLYDVLSVWPIMGDGPNQLSPYRARLAMALRGKNAHARLADIHVRHWQALAAQSGVPDAFAGMQALVE
RVPAGLERVEAILPPDFSGRVWSSVRTGVLAQAERFLNELASVTP

Download         Length: 1338 bp

>T225191 NZ_CP121070:3717948-3718205 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCGAAACCTGCATGACCACCAGTTACTCACATATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCGCAGCGTGACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAACAGCTTTACAAGGCTGAACAGGTGGTTAAGGGGATG
CGGGACGTGATTGTTTAG

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8754.07 Da        Isoelectric Point: 10.4693

>AT225191 WP_016725279.1 NZ_CP087277:c1311374-1311120 [Ralstonia solanacearum]
MESLLSSAPQLSAHLKSLRKARGLTQAQLGALLGVSQNRIADIEKDPGAVGFEQLLRILHALGAQLTLRTSAPAGTPSAA
PADW

Download         Length: 255 bp

>AT225191 NZ_CP121070:c3718123-3717791 [Salmonella enterica subsp. enterica serovar Infantis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCTCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0S4UDK5

Antitoxin

Source ID Structure
AlphaFold DB A0A0S4UDK3

References