Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5355359..5355984 Replicon chromosome
Accession NZ_CP087272
Organism Klebsiella pneumoniae strain ATCC BAA 2146

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag LN739_RS26590 Protein ID WP_002882817.1
Coordinates 5355359..5355742 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag LN739_RS26595 Protein ID WP_004150355.1
Coordinates 5355742..5355984 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN739_RS26575 (LN739_26575) 5352725..5353627 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
LN739_RS26580 (LN739_26580) 5353624..5354259 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
LN739_RS26585 (LN739_26585) 5354256..5355185 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
LN739_RS26590 (LN739_26590) 5355359..5355742 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
LN739_RS26595 (LN739_26595) 5355742..5355984 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
LN739_RS26600 (LN739_26600) 5356189..5357106 + 918 WP_002882812.1 alpha/beta hydrolase -
LN739_RS26605 (LN739_26605) 5357120..5358061 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
LN739_RS26610 (LN739_26610) 5358106..5358543 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
LN739_RS26615 (LN739_26615) 5358540..5359400 - 861 WP_002882807.1 virulence factor BrkB family protein -
LN739_RS26620 (LN739_26620) 5359394..5359993 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T225187 WP_002882817.1 NZ_CP087272:c5355742-5355359 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T225187 NZ_CP121070:1604816-1604968 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCCACAGCGAACGTTTTTAATGATGTTAATCGTCGTCTGTGTGACGATTCTGTGTTTTGTCTGGATGGTGAGGGATTC
GCTTTGCGGACTCCGGCTCCAGCAGGGAAACACAGTGCTTGTGGCAACGTTAGCCTACGAAGTTAAACGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT225187 WP_004150355.1 NZ_CP087272:c5355984-5355742 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT225187 NZ_CP121070:c1604764-1604704 [Salmonella enterica subsp. enterica serovar Infantis]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References