Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4149745..4150364 Replicon chromosome
Accession NZ_CP087272
Organism Klebsiella pneumoniae strain ATCC BAA 2146

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag LN739_RS20810 Protein ID WP_002892050.1
Coordinates 4150146..4150364 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag LN739_RS20805 Protein ID WP_002892066.1
Coordinates 4149745..4150119 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LN739_RS20795 (LN739_20795) 4144897..4146090 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LN739_RS20800 (LN739_20800) 4146113..4149259 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
LN739_RS20805 (LN739_20805) 4149745..4150119 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
LN739_RS20810 (LN739_20810) 4150146..4150364 + 219 WP_002892050.1 HHA domain-containing protein Toxin
LN739_RS20815 (LN739_20815) 4150523..4151089 + 567 WP_002892030.1 maltose O-acetyltransferase -
LN739_RS20820 (LN739_20820) 4151061..4151201 - 141 WP_004147370.1 hypothetical protein -
LN739_RS20825 (LN739_20825) 4151222..4151692 + 471 WP_002892026.1 YlaC family protein -
LN739_RS20830 (LN739_20830) 4151667..4153118 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
LN739_RS20835 (LN739_20835) 4153219..4153917 + 699 WP_002892021.1 GNAT family protein -
LN739_RS20840 (LN739_20840) 4153914..4154054 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
LN739_RS20845 (LN739_20845) 4154054..4154317 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T225183 WP_002892050.1 NZ_CP087272:4150146-4150364 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T225183 NZ_CP121070:317108-317476 [Salmonella enterica subsp. enterica serovar Infantis]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTTGGCATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT225183 WP_002892066.1 NZ_CP087272:4149745-4150119 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT225183 NZ_CP121070:316890-317111 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGATCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References