Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tad-ata/COG5606-COG4679 |
| Location | 6436..7129 | Replicon | plasmid pHD6448-1 |
| Accession | NZ_CP087267 | ||
| Organism | Aeromonas veronii strain HD6448 | ||
Toxin (Protein)
| Gene name | tad | Uniprot ID | - |
| Locus tag | KXU59_RS23940 | Protein ID | WP_000182276.1 |
| Coordinates | 6436..6792 (+) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | ata | Uniprot ID | N2IIN5 |
| Locus tag | KXU59_RS23945 | Protein ID | WP_001172026.1 |
| Coordinates | 6794..7129 (+) | Length | 112 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KXU59_RS23920 (LOS88_23920) | 1737..1931 | - | 195 | Protein_2 | ATP-binding protein | - |
| KXU59_RS23925 (LOS88_23925) | 2018..2587 | + | 570 | Protein_3 | IS110 family transposase | - |
| KXU59_RS23930 (LOS88_23930) | 2629..5658 | - | 3030 | WP_032432545.1 | Tn3 family transposase | - |
| KXU59_RS23935 (LOS88_23935) | 5642..6244 | - | 603 | WP_010465829.1 | recombinase family protein | - |
| KXU59_RS23940 (LOS88_23940) | 6436..6792 | + | 357 | WP_000182276.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| KXU59_RS23945 (LOS88_23945) | 6794..7129 | + | 336 | WP_001172026.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| KXU59_RS23950 (LOS88_23950) | 7144..7479 | + | 336 | WP_000741275.1 | hypothetical protein | - |
| KXU59_RS23955 (LOS88_23955) | 7503..7829 | + | 327 | WP_000091614.1 | hypothetical protein | - |
| KXU59_RS23960 (LOS88_23960) | 7826..8206 | + | 381 | WP_001054412.1 | hypothetical protein | - |
| KXU59_RS24780 | 8363..8623 | + | 261 | WP_239991406.1 | DUF3391 domain-containing protein | - |
| KXU59_RS23965 (LOS88_23965) | 8707..9576 | + | 870 | WP_223198360.1 | HD-GYP domain-containing protein | - |
| KXU59_RS23970 (LOS88_23970) | 9761..10195 | + | 435 | Protein_13 | IS110 family transposase | - |
| KXU59_RS23975 (LOS88_23975) | 10704..11756 | + | 1053 | WP_244776933.1 | DNA-binding protein | - |
| KXU59_RS23980 (LOS88_23980) | 11753..11932 | + | 180 | WP_244776932.1 | hypothetical protein | - |
| KXU59_RS23985 (LOS88_23985) | 11919..12095 | + | 177 | WP_244776931.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | aac(6')-Ib-cr / catB3 / blaCMY-8b / qacE / sul1 | - | 1..70555 | 70555 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12912.93 Da Isoelectric Point: 8.9018
>T225167 WP_000182276.1 NZ_CP087267:6436-6792 [Aeromonas veronii]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKELKGFGGAGVLKVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQEL
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKELKGFGGAGVLKVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQEL
Download Length: 357 bp
>T225167 NZ_CP121068:846747-847160 [Salmonella enterica subsp. enterica serovar Infantis]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTTCTGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTTCTGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA
Antitoxin
Download Length: 112 a.a. Molecular weight: 12201.39 Da Isoelectric Point: 10.6058
>AT225167 WP_001172026.1 NZ_CP087267:6794-7129 [Aeromonas veronii]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA
Download Length: 336 bp
>AT225167 NZ_CP121068:846500-846766 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|