Detailed information of TA system TA225166

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 5044877..5046450
• Replicon: chromosome
• Accession: NZ_CP087266
• Organism: Aeromonas veronii strain HD6448

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: KXU59_RS23790
• Protein ID: WP_244776308.1
• Coordinates: 5044877..5046196 (-)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: KXU59_RS23795
• Protein ID: WP_101323164.1
• Coordinates: 5046196..5046450 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXU59_RS23775 (LOS88_23775)	5040794..5041558	+	765	WP_124930500.1	ATP-binding cassette domain-containing protein	-
KXU59_RS23780 (LOS88_23780)	5041593..5042477	+	885	WP_244776332.1	ABC transporter substrate-binding protein	-
KXU59_RS23785 (LOS88_23785)	5042474..5044456	+	1983	WP_244776310.1	Fe(3+)-hydroxamate ABC transporter permease FhuB	-
KXU59_RS23790 (LOS88_23790)	5044877..5046196	-	1320	WP_244776308.1	type II toxin-antitoxin system HipA family toxin	Toxin
KXU59_RS23795 (LOS88_23795)	5046196..5046450	-	255	WP_101323164.1	helix-turn-helix domain-containing protein	Antitoxin
KXU59_RS23800 (LOS88_23800)	5046620..5047048	-	429	WP_118882200.1	DUF86 domain-containing protein	-
KXU59_RS23805 (LOS88_23805)	5047041..5047490	-	450	WP_160836704.1	nucleotidyltransferase domain-containing protein	-
KXU59_RS23810 (LOS88_23810)	5047937..5048560	+	624	WP_115522767.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49510.57 Da
• Isoelectric Point: 6.8288

>T225166 WP_244776308.1 NZ_CP087266:c5046196-5044877 [Aeromonas veronii]
MANLAVYMNGYRVGTFTKATSGAHQFQYHESWLAQPGSRPISLSMPLRHQPYRGDEAYNFFDNLLPDNMEVRNRVVARYQ
AASTQPFDLLSCIGQDSVGALQLVTEGHDVPDVRRIDYKALSDDELEQILTSYKSGIPLGMVREQDEFRISIAGAQEKTA
LLYLDGRWYLPLNATPTTHIIKLPIGKIESHSYSIDLSQSVENEYICTLIAKEFGLPVPHCFMMQVGQVKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSARKYESHGGPGITDIMKTLLGSATPEQDRYLFMKSQILFWLLAATDGHAKNFSVFI
EPEGRFRLTPFYDILSVYPVFGGRGLNRRDAKLAMGLASSKGKKYAIEQIFPRHFFQTAKAVGFERSAMEEILTELANSV
DDVIERVTQQLPTGFPDVISSSILEGLKARSARLIKGWD

Nucleotide

• Length: 1320 bp

>T225166 NZ_CP121068:316746-317114 [Salmonella enterica subsp. enterica serovar Infantis]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTTGGCATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGCGCCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9323.64 Da
• Isoelectric Point: 7.9834

>AT225166 WP_101323164.1 NZ_CP087266:c5046450-5046196 [Aeromonas veronii]
MKVTSAKQLSACIKDARLSQKLSQGKVAEKVGIRQDTVSSFELNPESTKLETLFKILAALELSLDIKPRNESSDSPTSGW
KEEW

Nucleotide

• Length: 255 bp

>AT225166 NZ_CP121068:316528-316749 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGATCTGGCGGATAAATGA