Detailed information of TA system TA225165

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Doc(toxin)
• Location: 2057310..2057887
• Replicon: chromosome
• Accession: NZ_CP087266
• Organism: Aeromonas veronii strain HD6448

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: KXU59_RS09725
• Protein ID: WP_182785848.1
• Coordinates: 2057310..2057708 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A6M4YTF0
• Locus tag: KXU59_RS09730
• Protein ID: WP_033137226.1
• Coordinates: 2057708..2057887 (-)
• Length: 60 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXU59_RS09725 (LOS88_09725)	2057310..2057708	-	399	WP_182785848.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
KXU59_RS09730 (LOS88_09730)	2057708..2057887	-	180	WP_033137226.1	hypothetical protein	Antitoxin
KXU59_RS09735 (LOS88_09735)	2058035..2058238	+	204	WP_244775954.1	hypothetical protein	-
KXU59_RS09740 (LOS88_09740)	2058358..2059445	+	1088	WP_088821966.1	IS3-like element ISAs22 family transposase	-
KXU59_RS09745 (LOS88_09745)	2059409..2059792	-	384	WP_244777015.1	hypothetical protein	-
KXU59_RS09750 (LOS88_09750)	2059868..2060251	-	384	WP_111896604.1	Arc family DNA-binding protein	-
KXU59_RS09755 (LOS88_09755)	2060823..2061770	+	948	WP_031285326.1	IS30 family transposase	-
KXU59_RS09760 (LOS88_09760)	2061779..2062549	+	771	WP_244776891.1	phage antirepressor N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1986469..2096530	110061

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Death on curing protein (36-107)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14492.52 Da
• Isoelectric Point: 4.1179

>T225165 WP_182785848.1 NZ_CP087266:c2057708-2057310 [Aeromonas veronii]
MDIIQFPPARVLEINHYILGASPGHQGPASIALLEGALGRIDNAIAYNGLNDVFLIAAKYAMAIGTAHAFSDANKRTGLA
VCLEYLSLNDFEIERDNEKLADAMVDLVLGELPEEWFADILYALWLEEQKTS

Nucleotide

• Length: 399 bp

>T225165 NZ_CP121068:204572-205057 [Salmonella enterica subsp. enterica serovar Infantis]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 60 a.a.
• Molecular weight: 6788.82 Da
• Isoelectric Point: 10.1555

>AT225165 WP_033137226.1 NZ_CP087266:c2057887-2057708 [Aeromonas veronii]
MKDNTVSNKYGLPQVQNRPQIKAEKNLCLNGEEGRQIIKSETKLTLKTHEKTFTRLADM

Nucleotide

• Length: 180 bp

>AT225165 NZ_CP121068:204297-204584 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCAGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Structures

Antitoxin

• AlphaFold DB: A0A6M4YTF0