Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 1111373..1111875 Replicon chromosome
Accession NZ_CP087266
Organism Aeromonas veronii strain HD6448

Toxin (Protein)


Gene name yoeB Uniprot ID Q5XQD8
Locus tag KXU59_RS05370 Protein ID WP_032492620.1
Coordinates 1111621..1111875 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1V0BEH6
Locus tag KXU59_RS05365 Protein ID WP_032492621.1
Coordinates 1111373..1111624 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KXU59_RS05335 (LOS88_05335) 1106805..1106990 - 186 WP_245147267.1 hypothetical protein -
KXU59_RS05340 (LOS88_05340) 1107179..1108126 - 948 WP_031285326.1 IS30 family transposase -
KXU59_RS05345 (LOS88_05345) 1108205..1109227 + 1023 WP_245147268.1 HAMP domain-containing methyl-accepting chemotaxis protein -
KXU59_RS05350 (LOS88_05350) 1109412..1110059 - 648 Protein_1022 dihydropteroate synthase -
KXU59_RS05355 (LOS88_05355) 1110053..1110400 - 348 WP_000679427.1 quaternary ammonium compound efflux SMR transporter QacE delta 1 -
KXU59_RS05360 (LOS88_05360) 1110557..1111189 - 633 WP_000186237.1 type B-3 chloramphenicol O-acetyltransferase CatB3 -
KXU59_RS05365 (LOS88_05365) 1111373..1111624 + 252 WP_032492621.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
KXU59_RS05370 (LOS88_05370) 1111621..1111875 + 255 WP_032492620.1 Txe/YoeB family addiction module toxin Toxin
KXU59_RS05375 (LOS88_05375) 1111948..1112502 - 555 WP_012695458.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase -
KXU59_RS05380 (LOS88_05380) 1112551..1113339 - 789 Protein_1028 AadA family aminoglycoside 3''-O-nucleotidyltransferase -
KXU59_RS05385 (LOS88_05385) 1113586..1114599 + 1014 WP_000845048.1 class 1 integron integrase IntI1 -
KXU59_RS05390 (LOS88_05390) 1114936..1115496 + 561 WP_001161490.1 recombinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island msr(E) / mph(E) / tet(E) / qacE / catB3 / ant(3'')-Ii-aac(6')-IId / mph(A) hcp / vgrG2 1042407..1193738 151331
- inside IScluster/Tn tet(E) / qacE / catB3 / ant(3'')-Ii-aac(6')-IId / mph(A) - 1092886..1129600 36714
- inside Integron - - 1110053..1114599 4546


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10272.81 Da        Isoelectric Point: 9.3585

>T225164 WP_032492620.1 NZ_CP087266:1111621-1111875 [Aeromonas veronii]
MRLIFSDDAWEDYLFWQKQDRRMVDRINKLIKETTREPFSGVGKPEPLKHALAGYWSRRITDEHRMVYKVADDALWIVQL
KYHY

Download         Length: 255 bp

>T225164 NZ_CP121067:50117-50422 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTACCGCCTGTTTGTGGATGTGCAGAGCGACATCGTCGATAC
CCCTGGCCGGCGAATGGTGATCCCGCTGGCCAGTGCCCGTCTGCTGTCGGATAAGGTCTCCCGCGAACTTTATCCGGTGG
TGCATATCGGGGATGAGAGCTGGCGTCTGATGACCACGGATATGGCCAGTGTCCCGGCCTCATTCATCGGGGAAGAGGTG
GCCGAGCTCAGCCACAGGGAGAACGACATCAAAAACGCCATTAACCTGATGTTCTGGGGGATCTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9244.40 Da        Isoelectric Point: 4.7769

>AT225164 WP_032492621.1 NZ_CP087266:1111373-1111624 [Aeromonas veronii]
MDAITYTHARANLAGTMDRVCNDHEPVIITRNGDQSVVILSLEDFQALEETAYLLRSPANAKRLFKSIEQLEAGRGQARE
LAE

Download         Length: 252 bp

>AT225164 NZ_CP121067:49897-50115 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAAGCAGCGTATTACTGTCACCATAGACAGTGACAGCTATCAGTTACTCAAGTCCGCAGACGTGAATATCTCCGGCCT
GGTAAATACTGCCATGCAGAAGGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAGCGAACGGCTCCTTTGCAGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V0BEH9

Antitoxin

Source ID Structure
AlphaFold DB A0A1V0BEH6

References