Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yoeB-relB/YoeB-YefM |
| Location | 1111373..1111875 | Replicon | chromosome |
| Accession | NZ_CP087266 | ||
| Organism | Aeromonas veronii strain HD6448 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | Q5XQD8 |
| Locus tag | KXU59_RS05370 | Protein ID | WP_032492620.1 |
| Coordinates | 1111621..1111875 (+) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A1V0BEH6 |
| Locus tag | KXU59_RS05365 | Protein ID | WP_032492621.1 |
| Coordinates | 1111373..1111624 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KXU59_RS05335 (LOS88_05335) | 1106805..1106990 | - | 186 | WP_245147267.1 | hypothetical protein | - |
| KXU59_RS05340 (LOS88_05340) | 1107179..1108126 | - | 948 | WP_031285326.1 | IS30 family transposase | - |
| KXU59_RS05345 (LOS88_05345) | 1108205..1109227 | + | 1023 | WP_245147268.1 | HAMP domain-containing methyl-accepting chemotaxis protein | - |
| KXU59_RS05350 (LOS88_05350) | 1109412..1110059 | - | 648 | Protein_1022 | dihydropteroate synthase | - |
| KXU59_RS05355 (LOS88_05355) | 1110053..1110400 | - | 348 | WP_000679427.1 | quaternary ammonium compound efflux SMR transporter QacE delta 1 | - |
| KXU59_RS05360 (LOS88_05360) | 1110557..1111189 | - | 633 | WP_000186237.1 | type B-3 chloramphenicol O-acetyltransferase CatB3 | - |
| KXU59_RS05365 (LOS88_05365) | 1111373..1111624 | + | 252 | WP_032492621.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
| KXU59_RS05370 (LOS88_05370) | 1111621..1111875 | + | 255 | WP_032492620.1 | Txe/YoeB family addiction module toxin | Toxin |
| KXU59_RS05375 (LOS88_05375) | 1111948..1112502 | - | 555 | WP_012695458.1 | AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase | - |
| KXU59_RS05380 (LOS88_05380) | 1112551..1113339 | - | 789 | Protein_1028 | AadA family aminoglycoside 3''-O-nucleotidyltransferase | - |
| KXU59_RS05385 (LOS88_05385) | 1113586..1114599 | + | 1014 | WP_000845048.1 | class 1 integron integrase IntI1 | - |
| KXU59_RS05390 (LOS88_05390) | 1114936..1115496 | + | 561 | WP_001161490.1 | recombinase family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | msr(E) / mph(E) / tet(E) / qacE / catB3 / ant(3'')-Ii-aac(6')-IId / mph(A) | hcp / vgrG2 | 1042407..1193738 | 151331 | |
| - | inside | IScluster/Tn | tet(E) / qacE / catB3 / ant(3'')-Ii-aac(6')-IId / mph(A) | - | 1092886..1129600 | 36714 | |
| - | inside | Integron | - | - | 1110053..1114599 | 4546 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10272.81 Da Isoelectric Point: 9.3585
>T225164 WP_032492620.1 NZ_CP087266:1111621-1111875 [Aeromonas veronii]
MRLIFSDDAWEDYLFWQKQDRRMVDRINKLIKETTREPFSGVGKPEPLKHALAGYWSRRITDEHRMVYKVADDALWIVQL
KYHY
MRLIFSDDAWEDYLFWQKQDRRMVDRINKLIKETTREPFSGVGKPEPLKHALAGYWSRRITDEHRMVYKVADDALWIVQL
KYHY
Download Length: 255 bp
>T225164 NZ_CP121067:50117-50422 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTACCGCCTGTTTGTGGATGTGCAGAGCGACATCGTCGATAC
CCCTGGCCGGCGAATGGTGATCCCGCTGGCCAGTGCCCGTCTGCTGTCGGATAAGGTCTCCCGCGAACTTTATCCGGTGG
TGCATATCGGGGATGAGAGCTGGCGTCTGATGACCACGGATATGGCCAGTGTCCCGGCCTCATTCATCGGGGAAGAGGTG
GCCGAGCTCAGCCACAGGGAGAACGACATCAAAAACGCCATTAACCTGATGTTCTGGGGGATCTGA
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTACCGCCTGTTTGTGGATGTGCAGAGCGACATCGTCGATAC
CCCTGGCCGGCGAATGGTGATCCCGCTGGCCAGTGCCCGTCTGCTGTCGGATAAGGTCTCCCGCGAACTTTATCCGGTGG
TGCATATCGGGGATGAGAGCTGGCGTCTGATGACCACGGATATGGCCAGTGTCCCGGCCTCATTCATCGGGGAAGAGGTG
GCCGAGCTCAGCCACAGGGAGAACGACATCAAAAACGCCATTAACCTGATGTTCTGGGGGATCTGA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9244.40 Da Isoelectric Point: 4.7769
>AT225164 WP_032492621.1 NZ_CP087266:1111373-1111624 [Aeromonas veronii]
MDAITYTHARANLAGTMDRVCNDHEPVIITRNGDQSVVILSLEDFQALEETAYLLRSPANAKRLFKSIEQLEAGRGQARE
LAE
MDAITYTHARANLAGTMDRVCNDHEPVIITRNGDQSVVILSLEDFQALEETAYLLRSPANAKRLFKSIEQLEAGRGQARE
LAE
Download Length: 252 bp
>AT225164 NZ_CP121067:49897-50115 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAAGCAGCGTATTACTGTCACCATAGACAGTGACAGCTATCAGTTACTCAAGTCCGCAGACGTGAATATCTCCGGCCT
GGTAAATACTGCCATGCAGAAGGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAGCGAACGGCTCCTTTGCAGACGAAAACAGGGACTGGTGA
ATGAAGCAGCGTATTACTGTCACCATAGACAGTGACAGCTATCAGTTACTCAAGTCCGCAGACGTGAATATCTCCGGCCT
GGTAAATACTGCCATGCAGAAGGAGGCCCGCCGTCTGCGTGCGGAACGCTGGCAGGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAGCGAACGGCTCCTTTGCAGACGAAAACAGGGACTGGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1V0BEH9 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1V0BEH6 |