Detailed information of TA system TA225163

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 1092001..1092694
• Replicon: chromosome
• Accession: NZ_CP087266
• Organism: Aeromonas veronii strain HD6448

Toxin (Protein)

• Gene name: tad
• Uniprot ID: -
• Locus tag: KXU59_RS05250
• Protein ID: WP_000182276.1
• Coordinates: 1092338..1092694 (-)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: N2IIN5
• Locus tag: KXU59_RS05245
• Protein ID: WP_001172026.1
• Coordinates: 1092001..1092336 (-)
• Length: 112 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
KXU59_RS05210 (LOS88_05210)	1087816..1088427	-	612	WP_015060246.1	recombinase family protein	-
KXU59_RS05215 (LOS88_05215)	1088636..1089166	-	531	WP_000172759.1	hypothetical protein	-
KXU59_RS05220 (LOS88_05220)	1089554..1090423	-	870	WP_223198360.1	HD-GYP domain-containing protein	-
KXU59_RS05230 (LOS88_05230)	1090924..1091304	-	381	WP_001054412.1	hypothetical protein	-
KXU59_RS05235 (LOS88_05235)	1091301..1091627	-	327	WP_000091614.1	hypothetical protein	-
KXU59_RS05240 (LOS88_05240)	1091651..1091986	-	336	WP_000741275.1	hypothetical protein	-
KXU59_RS05245 (LOS88_05245)	1092001..1092336	-	336	WP_001172026.1	helix-turn-helix transcriptional regulator	Antitoxin
KXU59_RS05250 (LOS88_05250)	1092338..1092694	-	357	WP_000182276.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
KXU59_RS05255 (LOS88_05255)	1092886..1093488	+	603	WP_010465829.1	recombinase family protein	-
KXU59_RS05260 (LOS88_05260)	1093472..1096501	+	3030	WP_032432545.1	Tn3 family transposase	-
KXU59_RS05265 (LOS88_05265)	1096544..1096903	+	360	WP_245147266.1	MFS transporter	-
KXU59_RS05270 (LOS88_05270)	1096921..1097577	+	657	WP_197724694.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	msr(E) / mph(E) / tet(E) / qacE / catB3 / ant(3'')-Ii-aac(6')-IId / mph(A)	hcp / vgrG2	1042407..1193738	151331
	-	inside	IScluster/Tn	tet(E) / qacE / catB3 / ant(3'')-Ii-aac(6')-IId / mph(A)	-	1092886..1129600	36714

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (16-109)

Antitoxin

• Cro/C1-type helix-turn-helix domain (40-93)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 12912.93 Da
• Isoelectric Point: 8.9018

>T225163 WP_000182276.1 NZ_CP087266:c1092694-1092338 [Aeromonas veronii]
MTNKEKPLEWIASSHKDLMALPSDVRRRFGYALSLAQIGDQDDAAKELKGFGGAGVLKVVEDDAGGTYRAVYTVKFAEAV
FVLHCFQKKSKSGIATPKADMDIIRARLKVAEVLAQEL

Nucleotide

• Length: 357 bp

>T225163 NZ_CP121067:c49046-48630 [Salmonella enterica subsp. enterica serovar Infantis]
GTGAAGAAAATGTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCCGAAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGCCACCGTATTGTGGTCTCGGCCATCACCTACTCAGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGTCACATTGAACTGGTTGACGCGTTCTGCGCCCGCCTCGATGCTATCCTGCCCTGGGACCGGGCC
GCGGTGAACGCCACCACGGAGATTAAGGTGGCGCTACGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCGATCGC
CGGGCACGCTATTGCCGCCGGCGCGGTACTGGTGACAAATAATACGCGGGAGTTTGAGCGGGTGCCGGGTCTTGTTCTGG
AAGACTGGGGAAGATAA

Antitoxin

Protein

• Length: 112 a.a.
• Molecular weight: 12201.39 Da
• Isoelectric Point: 10.6058

>AT225163 WP_001172026.1 NZ_CP087266:c1092336-1092001 [Aeromonas veronii]
MQKRIIEGVEVQRSSGNVFADLGLPDAEKLKIKTGLVVEIRRAMRALGLTQQAAAKRMGIPQPKVSGMMRGDFTNLSERK
LMDCLNRLGYDIEIKVRPAAEPIGHLTLATA

Nucleotide

• Length: 336 bp

>AT225163 NZ_CP121067:c49273-49043 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAGAACCGTATCTATTTTTAAAAACGGCAACAACCGCGCCATCCGCCTTCCCCGCGATCTGGATTTTGATGGAGTGAG
CGAGCTGGAAATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCTGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGGCTTTATGGCGGAGCGTGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Structures

Antitoxin

• AlphaFold DB: A0A024EKI7