Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 1049921..1051489 | Replicon | chromosome |
| Accession | NZ_CP087266 | ||
| Organism | Aeromonas veronii strain HD6448 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | - |
| Locus tag | KXU59_RS05015 | Protein ID | WP_244776801.1 |
| Coordinates | 1050176..1051489 (+) | Length | 438 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | - |
| Locus tag | KXU59_RS05010 | Protein ID | WP_103859234.1 |
| Coordinates | 1049921..1050172 (+) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KXU59_RS04990 (LOS88_04990) | 1045361..1046002 | - | 642 | WP_199416927.1 | hypothetical protein | - |
| KXU59_RS04995 (LOS88_04995) | 1046242..1047803 | + | 1562 | WP_245147257.1 | IS3-like element ISAs20 family transposase | - |
| KXU59_RS05000 (LOS88_05000) | 1048028..1048558 | + | 531 | WP_103859232.1 | hypothetical protein | - |
| KXU59_RS05005 (LOS88_05005) | 1048561..1049565 | + | 1005 | WP_181023135.1 | tyrosine-type recombinase/integrase | - |
| KXU59_RS05010 (LOS88_05010) | 1049921..1050172 | + | 252 | WP_103859234.1 | helix-turn-helix domain-containing protein | Antitoxin |
| KXU59_RS05015 (LOS88_05015) | 1050176..1051489 | + | 1314 | WP_244776801.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| KXU59_RS05020 (LOS88_05020) | 1051486..1051980 | + | 495 | WP_103859235.1 | hypothetical protein | - |
| KXU59_RS05025 (LOS88_05025) | 1052459..1052977 | + | 519 | WP_244776800.1 | hypothetical protein | - |
| KXU59_RS05030 (LOS88_05030) | 1053255..1053773 | + | 519 | WP_103859238.1 | type VI secretion system effector Hcp1 | - |
| KXU59_RS05035 (LOS88_05035) | 1053950..1054237 | + | 288 | WP_103859239.1 | type VI secretion system PAAR protein | - |
| KXU59_RS05040 (LOS88_05040) | 1054249..1056291 | + | 2043 | WP_244776799.1 | type VI secretion system tip protein VgrG | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | msr(E) / mph(E) / tet(E) / qacE / catB3 / ant(3'')-Ii-aac(6')-IId / mph(A) | hcp / vgrG2 | 1042407..1193738 | 151331 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 438 a.a. Molecular weight: 48193.41 Da Isoelectric Point: 6.0549
>T225162 WP_244776801.1 NZ_CP087266:1050176-1051489 [Aeromonas veronii]
MRMQTLNVAMNGEIVGTLYRDNRGAMSFQYAPEWISEPGSRAISMSLPLSHSRITGSEVFNFFSNLLPDSEAIIARMQAR
FSVETTHPFDLLASVGRDCVGAIQLYSPDADIPTVMETLAEPLDDAQIEQLLEGYQEAPLGMAEDADFRISIAGAQEKTA
LLWYQDCWQRPLGSTPTSHIFKLPIGKIVQNNIDLSESCENEWLCLRIAKAFGFDVANADLATFGKQKVLVVQRFDRRWS
KSGEWLLRLPQEDFCQALGIAPALKYESHGGPGIADAMKLLLGSRLAAKDREQFFKSQILFWMLAAIDGHGKNFSIFIEP
ASSFRMTPLYDVMSAFPIFKSGGIAAQKAKMGMALQGKNRQYHFAMIQPRHFISTAAHVGFPQDTAAQLMLEMATKTEVV
VATVAAELPAGFPEHISNTIFDGLASQAAKILKGVAK
MRMQTLNVAMNGEIVGTLYRDNRGAMSFQYAPEWISEPGSRAISMSLPLSHSRITGSEVFNFFSNLLPDSEAIIARMQAR
FSVETTHPFDLLASVGRDCVGAIQLYSPDADIPTVMETLAEPLDDAQIEQLLEGYQEAPLGMAEDADFRISIAGAQEKTA
LLWYQDCWQRPLGSTPTSHIFKLPIGKIVQNNIDLSESCENEWLCLRIAKAFGFDVANADLATFGKQKVLVVQRFDRRWS
KSGEWLLRLPQEDFCQALGIAPALKYESHGGPGIADAMKLLLGSRLAAKDREQFFKSQILFWMLAAIDGHGKNFSIFIEP
ASSFRMTPLYDVMSAFPIFKSGGIAAQKAKMGMALQGKNRQYHFAMIQPRHFISTAAHVGFPQDTAAQLMLEMATKTEVV
VATVAAELPAGFPEHISNTIFDGLASQAAKILKGVAK
Download Length: 1314 bp
>T225162 NZ_CP121067:28886-29368 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGAAATAAGTGTTACTGCACCGGAGTTGCTAAACGAGGAACACTATCTTCAACAGTTTGATTGCGGGAATGATGTGCT
CAGTGACTGGCTTCGCCGCAGAGCGATGAAGAACCAATACCTCAATGCCTCCCGTACATTTGTTATCTGCCCTGAAGGCA
CAAAGCGAGTAGTGGGATATTACTCTATTGCGACGGGGTCTGTAAGTCATGCCAGTTTAGGTCGCAGTTTACGCCAGAAT
ATGCCCGATCCTGTTCCGGTTGTTTTGCTGGGACGTCTTGCTGTTGATGAGTGTACTCAAGGGCATAGTTTTGGAAAATG
GCTGCTTAATGATGCTGTAACACGGGTATCTAACCTGGCAGACCAGGTGGGTATTAAAGCGATCATGGTTCATGCTATTG
ATGAACAGGCGAAAACATTCTATGAATACTTTGGCTTTGTTCAGTCTCCCATTGCGCCAAATACATTGTTCTACAAGATT
TAA
ATGGAAATAAGTGTTACTGCACCGGAGTTGCTAAACGAGGAACACTATCTTCAACAGTTTGATTGCGGGAATGATGTGCT
CAGTGACTGGCTTCGCCGCAGAGCGATGAAGAACCAATACCTCAATGCCTCCCGTACATTTGTTATCTGCCCTGAAGGCA
CAAAGCGAGTAGTGGGATATTACTCTATTGCGACGGGGTCTGTAAGTCATGCCAGTTTAGGTCGCAGTTTACGCCAGAAT
ATGCCCGATCCTGTTCCGGTTGTTTTGCTGGGACGTCTTGCTGTTGATGAGTGTACTCAAGGGCATAGTTTTGGAAAATG
GCTGCTTAATGATGCTGTAACACGGGTATCTAACCTGGCAGACCAGGTGGGTATTAAAGCGATCATGGTTCATGCTATTG
ATGAACAGGCGAAAACATTCTATGAATACTTTGGCTTTGTTCAGTCTCCCATTGCGCCAAATACATTGTTCTACAAGATT
TAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9364.82 Da Isoelectric Point: 9.8930
>AT225162 WP_103859234.1 NZ_CP087266:1049921-1050172 [Aeromonas veronii]
MKVTSPALLAAAVRDQRKISKLTQAEAAKQVGIKQTTVSDFELRPESTKLETLFKLLSALDLELHVVKRGSTLDDNKVWD
REW
MKVTSPALLAAAVRDQRKISKLTQAEAAKQVGIKQTTVSDFELRPESTKLETLFKLLSALDLELHVVKRGSTLDDNKVWD
REW
Download Length: 252 bp
>AT225162 NZ_CP121067:28611-28895 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCAAACTACAATCCGCAAATCTGTGCGTAATAAACAAATAAATATACGGGCTACTGATGAGGAACGTGCTGTGATTGA
TTATGCAGCGAGCCTGGTCAGTAAAAACCGTACCGACTTCATCATAGAAAAGGCTGTGAGCGAGGCCCAGAATATCATTC
TGGATCAACGCGTTTTTGTTCTGGATGATGCCCGCTATCAGGCTTTTATTAAACAACTTGAAGCTCCTGTACAGAATACT
GAAGGTCGTCAGCGCCTGATGGATGTGAAACCTGAATGGAAATAA
ATGCAAACTACAATCCGCAAATCTGTGCGTAATAAACAAATAAATATACGGGCTACTGATGAGGAACGTGCTGTGATTGA
TTATGCAGCGAGCCTGGTCAGTAAAAACCGTACCGACTTCATCATAGAAAAGGCTGTGAGCGAGGCCCAGAATATCATTC
TGGATCAACGCGTTTTTGTTCTGGATGATGCCCGCTATCAGGCTTTTATTAAACAACTTGAAGCTCCTGTACAGAATACT
GAAGGTCGTCAGCGCCTGATGGATGTGAAACCTGAATGGAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|