Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 4847851..4848516 Replicon chromosome
Accession NZ_CP087263
Organism Brevibacillus humidisoli strain MMS20-4M-10-Y

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LOK74_RS23665 Protein ID WP_230044450.1
Coordinates 4848166..4848516 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag LOK74_RS23660 Protein ID WP_277613413.1
Coordinates 4847851..4848162 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOK74_RS23630 (LOK74_23630) 4842910..4843830 + 921 WP_230044443.1 multidrug resistance efflux transporter family protein -
LOK74_RS23635 (LOK74_23635) 4843932..4844120 + 189 WP_230044444.1 gamma-type small acid-soluble spore protein -
LOK74_RS23640 (LOK74_23640) 4844223..4844606 + 384 WP_230044445.1 holo-ACP synthase -
LOK74_RS23645 (LOK74_23645) 4844881..4845909 + 1029 WP_230044446.1 outer membrane lipoprotein-sorting protein -
LOK74_RS23650 (LOK74_23650) 4846047..4846487 + 441 WP_230044447.1 hypothetical protein -
LOK74_RS23655 (LOK74_23655) 4846491..4847672 + 1182 WP_230044448.1 alanine racemase -
LOK74_RS23660 (LOK74_23660) 4847851..4848162 + 312 WP_277613413.1 ribbon-helix-helix protein, CopG family Antitoxin
LOK74_RS23665 (LOK74_23665) 4848166..4848516 + 351 WP_230044450.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LOK74_RS23670 (LOK74_23670) 4848756..4849157 + 402 WP_230044451.1 anti-sigma regulatory factor -
LOK74_RS23675 (LOK74_23675) 4849175..4850179 + 1005 WP_230044452.1 PP2C family protein-serine/threonine phosphatase -
LOK74_RS23680 (LOK74_23680) 4850238..4850579 + 342 WP_230044453.1 anti-sigma factor antagonist -
LOK74_RS23685 (LOK74_23685) 4850570..4851061 + 492 WP_230044454.1 anti-sigma B factor RsbW -
LOK74_RS23690 (LOK74_23690) 4851027..4851833 + 807 WP_230044455.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(19-56)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12962.99 Da        Isoelectric Point: 4.8606

>T225160 WP_230044450.1 NZ_CP087263:4848166-4848516 [Brevibacillus humidisoli]
VIVKRGDVFFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKLYGFDRDSVILLEQI
RTIDKQRLTDKITRLDDEMMERVNESLQISLGLIDF

Download         Length: 351 bp

>T225160 NZ_CP121066:4660846-4661157 [Salmonella enterica subsp. enterica serovar Infantis]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATACTATCGGGGTAATAAAGAATGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11688.55 Da        Isoelectric Point: 8.5368

>AT225160 WP_277613413.1 NZ_CP087263:4847851-4848162 [Brevibacillus humidisoli]
MSLGHGGGGFVLSKTNTKRIMISLPQHLLQEVDGVVEKEKSNRSELIRQAMSLYLKERKKRFIRETMQKGYMEMAKINLN
MASEAFEAEEEADLTLDRLVSGV

Download         Length: 312 bp

>AT225160 NZ_CP121066:4661154-4661600 [Salmonella enterica subsp. enterica serovar Infantis]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAACCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References