Detailed information of TA system TA225159

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3423243..3423877
• Replicon: chromosome
• Accession: NZ_CP087226
• Organism: Dickeya fangzhongdai strain B16

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: QR68_RS14770
• Protein ID: WP_038919729.1
• Coordinates: 3423473..3423877 (+)
• Length: 135 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: QR68_RS14765
• Protein ID: WP_038919728.1
• Coordinates: 3423243..3423473 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QR68_RS14755 (QR68_14755)	3420186..3421294	+	1109	Protein_2898	IS3 family transposase	-
QR68_RS14760 (QR68_14760)	3421488..3422909	-	1422	WP_231348807.1	DUF2235 domain-containing protein	-
QR68_RS14765 (QR68_14765)	3423243..3423473	+	231	WP_038919728.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
QR68_RS14770 (QR68_14770)	3423473..3423877	+	405	WP_038919729.1	tRNA(fMet)-specific endonuclease VapC	Toxin
QR68_RS14775 (QR68_14775)	3424154..3427399	-	3246	WP_038919730.1	type I Zorya anti-phage system protein ZorD	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3420941..3433791	12850
	-	flank	IS/Tn	-	-	3420186..3420452	266

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-124)

Antitoxin

• SpoVT-AbrB domain (7-54)

Sequences

Toxin

Protein

• Length: 135 a.a.
• Molecular weight: 15085.32 Da
• Isoelectric Point: 7.9926

>T225159 WP_038919729.1 NZ_CP087226:3423473-3423877 [Dickeya fangzhongdai]
MLKYLLDTNICIYTIKNKPQEVRDAFYRYYGQFAISAITLMELIYGAEKSVNPEKNLAVIEGFSARLEVQTYGFDAAVHT
GQIRAELARQGTPIGPYDAMLAGHARSAGLILVTNNVREFERVPGLRVENWVSR

Nucleotide

• Length: 405 bp

>T225159 NZ_CP121066:c4659613-4659302 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8708.78 Da
• Isoelectric Point: 4.3193

>AT225159 WP_038919728.1 NZ_CP087226:3423243-3423473 [Dickeya fangzhongdai]
MEKTTVFKSNRSQAVRLPKAVALPDDVKQVDIVAIGRTRIITPAGESWDSWFEEEGVTPDFMITREQPDDQIREDF

Nucleotide

• Length: 231 bp

>AT225159 NZ_CP121066:c4659301-4659011 [Salmonella enterica subsp. enterica serovar Infantis]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAACCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAGC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA