Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DhiAT/dnstrm_HI1420(antitoxin)
Location 1712990..1713743 Replicon chromosome
Accession NZ_CP087226
Organism Dickeya fangzhongdai strain B16

Toxin (Protein)


Gene name dhiT Uniprot ID A0A2K8QMG8
Locus tag QR68_RS07480 Protein ID WP_038918519.1
Coordinates 1712990..1713247 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name dhiA Uniprot ID A0A2K8QKC0
Locus tag QR68_RS07485 Protein ID WP_038918520.1
Coordinates 1713255..1713743 (+) Length 163 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
QR68_RS07470 (QR68_07470) 1709765..1711915 - 2151 WP_038918518.1 formate dehydrogenase subunit alpha -
QR68_RS07475 (QR68_07475) 1711950..1712492 - 543 WP_013317225.1 4Fe-4S dicluster domain-containing protein -
QR68_RS07480 (QR68_07480) 1712990..1713247 + 258 WP_038918519.1 DUF4160 domain-containing protein Toxin
QR68_RS07485 (QR68_07485) 1713255..1713743 + 489 WP_038918520.1 addiction module antitoxin Antitoxin
QR68_RS07490 (QR68_07490) 1713828..1714325 - 498 WP_038918521.1 hydrogenase maturation peptidase HycI -
QR68_RS07495 (QR68_07495) 1714318..1714716 - 399 WP_038660229.1 formate hydrogenlyase maturation HycH family protein -
QR68_RS07500 (QR68_07500) 1714713..1715504 - 792 WP_038918522.1 NADH-quinone oxidoreductase subunit B family protein -
QR68_RS07505 (QR68_07505) 1715501..1716070 - 570 WP_038918524.1 hydrogenase 4 subunit H -
QR68_RS07510 (QR68_07510) 1716081..1717808 - 1728 WP_038918525.1 hydrogenase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Protein of unknown function DUF4160

(9-74)

Antitoxin

Uncharacterized protein HI1420

(79-157)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9977.52 Da        Isoelectric Point: 8.1489

>T225150 WP_038918519.1 NZ_CP087226:1712990-1713247 [Dickeya fangzhongdai]
MPEIDRLAGLIFHLYFYDDERHHLPHVHVCYGNHELIISIRTGTEIEGYLPNNKRKLALAHIRAHREQLLSMWERAVVGR
NPGKL

Download         Length: 258 bp

>T225150 NZ_CP121066:317108-317476 [Salmonella enterica subsp. enterica serovar Infantis]
ATGACCCTACAACTTATCTCAGCGGAAGAGATAATTCAGTTTCACGACAGGCTTCTCCGCGTTACGCCTGGTGTAACAGG
CATGCCTGATCCTGGCCGCGCGGAAGCGCTAATGTACCGGGTACTCAATCAAATCGAATATGAAGGGGTGACCGACGTGT
GGCTGCTGGCGGCAATGCATTTGCTCGCTATATCCCGTTGGCATATCTTCAATGATGGTAACAAACGCACCGCCTTATTT
ATTACGCTGCTGTTTTTAAAGCGTAACGGGATCTCACTCGCTGCGAATCCGGATTTTGTCGATATGACAGTCGATGCGGC
GGCAGGGCGGCTTACGCTGGAGCAAATTGCCGTTCGCTTACGCGCCTGA

Antitoxin


Download         Length: 163 a.a.        Molecular weight: 17940.51 Da        Isoelectric Point: 6.9795

>AT225150 WP_038918520.1 NZ_CP087226:1713255-1713743 [Dickeya fangzhongdai]
MHKIVEVDVIGDFSLRLTYEDGLVCDINLYQYASSPVFSNASLFIKFGLLPDGSLEWSPDIKISASELRKKGEYVSHTLA
VREKNFADVISRAFYDAVIENRPEILQAALKIAVEKHGNSTVAKEAGAKSRTSLYKSLNKNTHVSLATVVSLAHTVLQLE
EK

Download         Length: 489 bp

>AT225150 NZ_CP121066:316890-317111 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCGTACGGTTAACTATAGCGAAGCGCGGCAAAATCTGGCCGAAGTCCTGGAAAGCGCGGTGACGGCGGGCCCTGTCAC
CATCACGCGTCGTGGGCATAAGTCCGCAGTGATCATCAGCGCCGAGGAGTTTGAGCGTTATCAGACGGCGCGAATGGATG
ATGAGTTTGCTGCCATTATGGCGGTTCATGGCAATGAGCTCAGGGATCTGGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2K8QMG8

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8QKC0

References