Detailed information of TA system TA225149

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1689603..1690156
• Replicon: chromosome
• Accession: NZ_CP087226
• Organism: Dickeya fangzhongdai strain B16

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: QR68_RS07390
• Protein ID: WP_038900914.1
• Coordinates: 1689842..1690156 (+)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: QR68_RS07385
• Protein ID: WP_038918488.1
• Coordinates: 1689603..1689839 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QR68_RS07370 (QR68_07370)	1685051..1686286	-	1236	WP_038918486.1	DNA cytosine methyltransferase	-
QR68_RS07375 (QR68_07375)	1686571..1687593	+	1023	WP_038920880.1	DUF4917 family protein	-
QR68_RS07380 (QR68_07380)	1688338..1689282	+	945	WP_038918487.1	zincin-like metallopeptidase domain-containing protein	-
QR68_RS07385 (QR68_07385)	1689603..1689839	+	237	WP_038918488.1	type II toxin-antitoxin system CcdA family antitoxin	Antitoxin
QR68_RS07390 (QR68_07390)	1689842..1690156	+	315	WP_038900914.1	CcdB family protein	Toxin
QR68_RS07395 (QR68_07395)	1690153..1690275	-	123	Protein_1441	mobilization protein mobC	-
QR68_RS07400 (QR68_07400)	1690479..1692131	+	1653	WP_038918489.1	hypothetical protein	-
QR68_RS07405 (QR68_07405)	1692131..1693621	+	1491	WP_038918490.1	hypothetical protein	-
QR68_RS07410 (QR68_07410)	1693893..1695002	-	1110	WP_198677320.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1656181..1698490	42309

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-103)

Antitoxin

• Post-segregation antitoxin CcdA (9-78)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 11473.41 Da
• Isoelectric Point: 7.9859

>T225149 WP_038900914.1 NZ_CP087226:1689842-1690156 [Dickeya fangzhongdai]
MQFTVYGNTGKSAIYPLLLDVTSDIIGQLNRRIVIPLLPVEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQVKAAIDFLIDGI

Nucleotide

• Length: 315 bp

>T225149 NZ_CP121066:204572-205057 [Salmonella enterica subsp. enterica serovar Infantis]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9008.01 Da
• Isoelectric Point: 6.2206

>AT225149 WP_038918488.1 NZ_CP087226:1689603-1689839 [Dickeya fangzhongdai]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLSTALDAELRHHEAKKWQEENREAIDALNRFHDEQGCFSDEYRTF

Nucleotide

• Length: 237 bp

>AT225149 NZ_CP121066:204297-204584 [Salmonella enterica subsp. enterica serovar Infantis]
ATGCTATACAAAGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCAGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA