Detailed information of TA system TA225147

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): ccdAB/CcdA(antitoxin)
• Location: 1018904..1019430
• Replicon: chromosome
• Accession: NZ_CP087226
• Organism: Dickeya fangzhongdai strain B16

Toxin (Protein)

• Gene name: ccdB
• Uniprot ID: -
• Locus tag: QR68_RS04560
• Protein ID: WP_038918043.1
• Coordinates: 1018904..1019209 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: ccdA
• Uniprot ID: -
• Locus tag: QR68_RS04565
• Protein ID: WP_038918044.1
• Coordinates: 1019212..1019430 (-)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QR68_RS04550 (QR68_04550)	1015517..1017526	+	2010	WP_193745938.1	helicase-related protein	-
QR68_RS04555 (QR68_04555)	1017528..1018793	+	1266	WP_038918041.1	GIY-YIG nuclease family protein	-
QR68_RS04560 (QR68_04560)	1018904..1019209	-	306	WP_038918043.1	type II toxin-antitoxin system toxin CcdB	Toxin
QR68_RS04565 (QR68_04565)	1019212..1019430	-	219	WP_038918044.1	type II toxin-antitoxin system antitoxin CcdA	Antitoxin
QR68_RS04570 (QR68_04570)	1019489..1020232	-	744	WP_038918045.1	MobC family replication-relaxation protein	-
QR68_RS04575 (QR68_04575)	1021136..1021477	-	342	WP_038918046.1	hypothetical protein	-
QR68_RS04580 (QR68_04580)	1021934..1023196	-	1263	WP_038918047.1	integrase arm-type DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	983656..1021477	37821

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin CcdB (2-100)

Antitoxin

• Post-segregation antitoxin CcdA (2-72)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11821.72 Da
• Isoelectric Point: 4.6873

>T225147 WP_038918043.1 NZ_CP087226:c1019209-1018904 [Dickeya fangzhongdai]
MQFIVYQYKRASHYKMFVDVQSDIVETPKRRMVIPLIESHHLSEKVNKMLFPLLRIDGEDYRLMTTELSSVPVEVIGEEI
ADLGDYADEIKDAINLMFWGI

Nucleotide

• Length: 306 bp

>T225147 NZ_CP121004:c23253-22948 [Salmonella enterica]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8220.17 Da
• Isoelectric Point: 7.0142

>AT225147 WP_038918044.1 NZ_CP087226:c1019430-1019212 [Dickeya fangzhongdai]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNEAIGKEARRIRAEEWKKENREGMEEVARFIAQNGSFADENRNW

Nucleotide

• Length: 219 bp

>AT225147 NZ_CP121004:c23473-23255 [Salmonella enterica]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA