Detailed information of TA system TA225146

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 714603..715281
• Replicon: chromosome
• Accession: NZ_CP087226
• Organism: Dickeya fangzhongdai strain B16

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: QR68_RS03320
• Protein ID: WP_023637601.1
• Coordinates: 714850..715281 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A2K8QSU7
• Locus tag: QR68_RS03315
• Protein ID: WP_023637600.1
• Coordinates: 714603..714869 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
QR68_RS03295 (QR68_03295)	711049..711699	+	651	WP_038917839.1	LysE family translocator	-
QR68_RS03300 (QR68_03300)	711770..712378	-	609	WP_038917841.1	HD domain-containing protein	-
QR68_RS03305 (QR68_03305)	712589..713239	+	651	WP_038917842.1	hemolysin III family protein	-
QR68_RS03310 (QR68_03310)	713312..714292	-	981	WP_038917843.1	tRNA-modifying protein YgfZ	-
QR68_RS03315 (QR68_03315)	714603..714869	+	267	WP_023637600.1	FAD assembly factor SdhE	Antitoxin
QR68_RS03320 (QR68_03320)	714850..715281	+	432	WP_023637601.1	protein YgfX	Toxin
QR68_RS03325 (QR68_03325)	715381..715899	-	519	WP_038917844.1	flavodoxin FldB	-
QR68_RS03330 (QR68_03330)	716028..717353	-	1326	WP_038662304.1	MFS transporter	-
QR68_RS03335 (QR68_03335)	717616..718515	+	900	WP_038917846.1	site-specific tyrosine recombinase XerD	-
QR68_RS03340 (QR68_03340)	718604..719320	+	717	WP_038917847.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16808.51 Da
• Isoelectric Point: 11.7737

>T225146 WP_023637601.1 NZ_CP087226:714850-715281 [Dickeya fangzhongdai]
VAQWQCDLRVSWRMQLFSLLTHGFLVLMILLAPWPDGYAPLWLGLVTLVVFGFVRSQRIIKSRQGEISLHGENQLHWQQR
DWQIARRPWVMRNGVLLSLRATTGKGHQRLWLASDSMGNEEWRLLRQLLQQHPLQGTESSRHH

Nucleotide

• Length: 432 bp

>T225146 NZ_CP121003:4490185-4490496 [Salmonella enterica]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCTCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACACTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGCACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATGATCGGGGTAATAAAGAATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10544.03 Da
• Isoelectric Point: 5.5535

>AT225146 WP_023637600.1 NZ_CP087226:714603-714869 [Dickeya fangzhongdai]
MDINNKSRIHWACRRGMRELDISIMPFFEHEYDTLSDDDKQHFIRLLQCDDPDLFNWLMNHGEPVDPELKRMVSLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT225146 NZ_CP121003:4490493-4490939 [Salmonella enterica]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTCAAACTACCAGCAGATGCCTTCATCGAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A2K8QSU7