Detailed information of TA system TA225141

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 1879177..1880216
• Replicon: chromosome
• Accession: NZ_CP087205
• Organism: Pseudomonas sp. B21-053

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: -
• Locus tag: LOY68_RS08595
• Protein ID: WP_265044129.1
• Coordinates: 1879177..1879752 (-)
• Length: 192 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: A0A9E8B8C7
• Locus tag: LOY68_RS08600
• Protein ID: WP_054049618.1
• Coordinates: 1879749..1880216 (-)
• Length: 156 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOY68_RS08570 (LOY68_08555)	1874504..1876492	+	1989	WP_054049389.1	heme lyase CcmF/NrfE family subunit	-
LOY68_RS08575 (LOY68_08560)	1876489..1877025	+	537	WP_054615743.1	DsbE family thiol:disulfide interchange protein	-
LOY68_RS08580 (LOY68_08565)	1877022..1877492	+	471	WP_054049393.1	cytochrome c-type biogenesis protein CcmH	-
LOY68_RS08585 (LOY68_08570)	1877489..1878688	+	1200	WP_265044127.1	c-type cytochrome biogenesis protein CcmI	-
LOY68_RS08590 (LOY68_08575)	1878703..1879107	+	405	WP_265044128.1	hypothetical protein	-
LOY68_RS08595 (LOY68_08580)	1879177..1879752	-	576	WP_265044129.1	PIN domain-containing protein	Toxin
LOY68_RS08600 (LOY68_08585)	1879749..1880216	-	468	WP_054049618.1	helix-turn-helix domain-containing protein	Antitoxin
LOY68_RS08605 (LOY68_08590)	1880300..1881187	-	888	WP_265044130.1	LysR family transcriptional regulator	-
LOY68_RS08610 (LOY68_08595)	1881347..1882066	-	720	WP_265044131.1	SDR family oxidoreductase	-
LOY68_RS08615 (LOY68_08600)	1882115..1882771	-	657	WP_265044132.1	peroxiredoxin-like family protein	-
LOY68_RS08620 (LOY68_08605)	1882976..1884181	-	1206	WP_265044133.1	MFS transporter	-
LOY68_RS08625 (LOY68_08610)	1884417..1885046	+	630	WP_265044134.1	DUF5666 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-115)

Antitoxin

• Helix-turn-helix domain, group 17 (84-132)

Sequences

Toxin

Protein

• Length: 192 a.a.
• Molecular weight: 21762.84 Da
• Isoelectric Point: 5.0415

>T225141 WP_265044129.1 NZ_CP087205:c1879752-1879177 [Pseudomonas sp. B21-053]
VRHSPFTAVYDACVLYPAPLRDFLMWLALSGRFRARWSLEIHNEWKRNLLKNRPDLTTEQLDRTSELMDQAIPDANVSGY
EDLIEGLTLPDMNDRHVLAAAIRCNASVIVTFNQKDFPCTSLEPFGVEAQHPDEFVDNLFDLDPAAVVGAAQRQRKQLKM
PPMDVSTYLDLLSRQGLVRSVETLTTYRTIL

Nucleotide

• Length: 576 bp

>T225141 NZ_CP121003:c3987519-3987232 [Salmonella enterica]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 156 a.a.
• Molecular weight: 17304.74 Da
• Isoelectric Point: 6.2258

>AT225141 WP_054049618.1 NZ_CP087205:c1880216-1879749 [Pseudomonas sp. B21-053]
MSLVIHPPINLPIAREVQAAIEGQRALSAYLATQFETQRIQIFDEQNEAHNVELPTSALRLLVDILAALAEGNAVKVVPV
HAELTTQEAADLLNVSRPHLIKLLESGELSYHKTGKHRRVRFADLMDYKNRRDTASEQAMTLLAEQAQALRTGYE

Nucleotide

• Length: 468 bp

>AT225141 NZ_CP121003:c3987245-3986943 [Salmonella enterica]
ATGAGCATGGTTAAACATAAACGCGGCAATGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG