Detailed information of TA system TA225138

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/RHH(antitoxin)
• Location: 3974411..3974964
• Replicon: chromosome
• Accession: NZ_CP087204
• Organism: Pseudomonas sp. B21-054

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LOY70_RS17295
• Protein ID: WP_265028609.1
• Coordinates: 3974411..3974704 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LOY70_RS17300
• Protein ID: WP_265028610.1
• Coordinates: 3974692..3974964 (-)
• Length: 91 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOY70_RS17280 (LOY70_17235)	3969985..3970746	+	762	WP_265028606.1	efflux RND transporter periplasmic adaptor subunit	-
LOY70_RS17285 (LOY70_17240)	3970743..3972119	+	1377	WP_265028607.1	biotin/lipoyl-binding protein	-
LOY70_RS17290 (LOY70_17245)	3972116..3974290	+	2175	WP_265028608.1	HlyD family efflux transporter periplasmic adaptor subunit	-
LOY70_RS17295 (LOY70_17250)	3974411..3974704	-	294	WP_265028609.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOY70_RS17300 (LOY70_17255)	3974692..3974964	-	273	WP_265028610.1	CopG family ribbon-helix-helix protein	Antitoxin
LOY70_RS17305 (LOY70_17260)	3975301..3976980	+	1680	WP_265028611.1	thiamine pyrophosphate-binding protein	-
LOY70_RS17310 (LOY70_17265)	3976997..3977815	-	819	WP_265028612.1	helix-turn-helix transcriptional regulator	-
LOY70_RS17320 (LOY70_17275)	3978795..3979010	-	216	WP_265028613.1	DUF6434 domain-containing protein	-
LOY70_RS17325 (LOY70_17280)	3979332..3979940	-	609	WP_265028614.1	LysE family translocator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-95)

Antitoxin

• Ribbon-helix-helix protein, CopG (3-40)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11053.68 Da
• Isoelectric Point: 5.7302

>T225138 WP_265028609.1 NZ_CP087204:c3974704-3974411 [Pseudomonas sp. B21-054]
VPRLILTAGAGEGLERCRRFLLEKDPQVTRRAAQAIEQQLMRLETDPHVGRPVDDMPELRELVIAFGDAGYVALYRFVPA
EETVYVLAFRHQREAGY

Nucleotide

• Length: 294 bp

>T225138 NZ_CP121003:c2693321-2693218 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 91 a.a.
• Molecular weight: 10515.62 Da
• Isoelectric Point: 4.8838

>AT225138 WP_265028610.1 NZ_CP087204:c3974964-3974692 [Pseudomonas sp. B21-054]
MATSIKIDEDLKYRIQQLASARQRSAHWIMREALSQYVVREEARESFKQEALASWTAYQETGQHLTGAETRDWLKTWGTD
EESELPTCHD

Nucleotide

• Length: 273 bp

>AT225138 NZ_CP121003:2693216-2693361 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG