Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 2338527..2339131 Replicon chromosome
Accession NZ_CP087204
Organism Pseudomonas sp. B21-054

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LOY70_RS10495 Protein ID WP_265036078.1
Coordinates 2338838..2339131 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID W8PQG3
Locus tag LOY70_RS10490 Protein ID WP_025212841.1
Coordinates 2338527..2338835 (-) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY70_RS10450 (LOY70_10425) 2334138..2334782 + 645 WP_265036063.1 hypothetical protein -
LOY70_RS10455 (LOY70_10430) 2334811..2335338 + 528 WP_265036065.1 hypothetical protein -
LOY70_RS10460 (LOY70_10435) 2335488..2335949 + 462 WP_265036067.1 hypothetical protein -
LOY70_RS10465 (LOY70_10440) 2336005..2336535 - 531 WP_265036069.1 DUF2867 domain-containing protein -
LOY70_RS10470 (LOY70_10445) 2336555..2337187 - 633 WP_265036071.1 DJ-1/PfpI family protein -
LOY70_RS10475 (LOY70_10450) 2337312..2337866 + 555 WP_265036073.1 TetR/AcrR family transcriptional regulator -
LOY70_RS10480 (LOY70_10455) 2337954..2338157 + 204 WP_025212839.1 hypothetical protein -
LOY70_RS10485 (LOY70_10460) 2338190..2338474 + 285 WP_265036076.1 hypothetical protein -
LOY70_RS10490 (LOY70_10465) 2338527..2338835 - 309 WP_025212841.1 putative addiction module antidote protein Antitoxin
LOY70_RS10495 (LOY70_10470) 2338838..2339131 - 294 WP_265036078.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOY70_RS10500 (LOY70_10475) 2339999..2340883 - 885 WP_265036080.1 LysR substrate-binding domain-containing protein -
LOY70_RS10505 (LOY70_10480) 2340990..2341439 + 450 WP_265036082.1 PACE efflux transporter -
LOY70_RS10510 (LOY70_10485) 2341532..2341975 - 444 WP_265036084.1 hypothetical protein -
LOY70_RS10515 (LOY70_10490) 2342042..2342452 + 411 WP_265036085.1 hypothetical protein -
LOY70_RS10520 (LOY70_10495) 2342599..2342967 + 369 WP_265036087.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2334138..2344969 10831


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-97)

Antitoxin

Uncharacterized protein HI1420

(5-93)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10572.25 Da        Isoelectric Point: 10.8628

>T225137 WP_265036078.1 NZ_CP087204:c2339131-2338838 [Pseudomonas sp. B21-054]
MNYLIQQTQTFIAWHSSVRDLRAKIAIARRIDRAAAGNLGDVKPVGDGISELRVDVGAGYRVYFTMRGGVVIVLLAGGDK
SSQSADIRRAKKLAKEI

Download         Length: 294 bp

>T225137 NZ_CP121003:c2443853-2443698 [Salmonella enterica]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10958.37 Da        Isoelectric Point: 5.9574

>AT225137 WP_025212841.1 NZ_CP087204:c2338835-2338527 [Pseudomonas sp. B21-054]
MSQHLTTFDMAALLDSDEAISEYLSQVLADGDSEEFLRAIGYVAKARGMAQIAKDSGMGRESLYKAFAPGSKPRFDTVLK
VIHALGIDLHAQPGHATNHSPA

Download         Length: 309 bp

>AT225137 NZ_CP121003:2443865-2443923 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References