Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 291995..292671 Replicon chromosome
Accession NZ_CP087200
Organism Pseudomonas viciae strain B21-062

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOY66_RS01255 Protein ID WP_135843170.1
Coordinates 291995..292177 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOY66_RS01260 Protein ID WP_135847931.1
Coordinates 292270..292671 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY66_RS01240 (LOY66_01235) 288032..289993 + 1962 WP_265073083.1 choline transporter BetT -
LOY66_RS01245 (LOY66_01240) 290117..290857 - 741 WP_135843168.1 SDR family oxidoreductase -
LOY66_RS01250 (LOY66_01245) 290975..291865 + 891 WP_135843169.1 LysR family transcriptional regulator -
LOY66_RS01255 (LOY66_01250) 291995..292177 + 183 WP_135843170.1 type II toxin-antitoxin system HicA family toxin Toxin
LOY66_RS01260 (LOY66_01255) 292270..292671 + 402 WP_135847931.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOY66_RS01265 (LOY66_01260) 292737..293774 + 1038 WP_135843171.1 L-glyceraldehyde 3-phosphate reductase -
LOY66_RS01270 (LOY66_01265) 293831..294673 - 843 WP_265072581.1 taurine dioxygenase -
LOY66_RS01275 (LOY66_01270) 294724..295563 - 840 WP_265072582.1 taurine ABC transporter permease TauC -
LOY66_RS01280 (LOY66_01275) 295560..296354 - 795 WP_265072583.1 taurine ABC transporter ATP-binding subunit -
LOY66_RS01285 (LOY66_01280) 296380..297357 - 978 WP_135843175.1 taurine ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6871.99 Da        Isoelectric Point: 10.6627

>T225115 WP_135843170.1 NZ_CP087200:291995-292177 [Pseudomonas viciae]
MRSREMIRKIEEDGWYLVAVKGSHHQYKHSFKAGRVTIKHPDADLPKGTINSILKQAGLK

Download         Length: 183 bp

>T225115 NZ_CP120974:2671233-2671487 [Moellerella wisconsensis]
GTGAAGCTAACATGGTCTGCCGAAGCATGGGAAGATTACTTGTACTGGCAAGAAACGGACAGAAAAACCGTAAAAAAGAT
AAATGAGCTCATTAAGAATGCCAGTAGAACACCATTTGAAGGAAAAGGTAAACCTGAACCTCTGAAACACAATCTTGCTG
GGTTCTGGTCACGAAGAATTACGGCGGAACATCGATTAGTCTATGCCGTTAGTAATGATTCCTTGCTAATAGCATCATGT
CGTTATCACTACTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14625.30 Da        Isoelectric Point: 4.4085

>AT225115 WP_135847931.1 NZ_CP087200:292270-292671 [Pseudomonas viciae]
MKFPVVLHKDADSEYGVTVPDVPGCFSAGSTVGQAFENVKEALSLHYEGLVADGEPLPQIHEIDDHLDNPDYAGGIWGVV
EFDVTPYFGKSVRFNATLPEQLLERIDQTVRRDQRYSSRSGFLAAAALRELSA

Download         Length: 402 bp

>AT225115 NZ_CP120974:2670985-2671236 [Moellerella wisconsensis]
ATGAAAGCGGTAAGCTACAGTGAAGCCAGACAGAATTTATCAACAACAATGATTCAAACAGTTGAAGATAGAGTACCAGT
ACTGATCACGCGCCAGAATGGCGAATCATGTGTACTGATGTCTCTCGATGAATATAACTCTCTCGAAGAGACGGCATACC
TAATGAGATCACCAAAAAATGCACGCAGACTTATGGACTCGATAGAAAGCCTAAAAGATGGAAAAGGGATGGAAAGGGAA
ATTATTAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References