Detailed information of TA system TA022511

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YefM
• Location: 2574519..2575093
• Replicon: chromosome
• Accession: NC_009943
• Organism: Desulfococcus oleovorans Hxd3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A8ZTZ0
• Locus tag: DOLE_RS10890
• Protein ID: WP_012175535.1
• Coordinates: 2574519..2574815 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A8ZTZ1
• Locus tag: DOLE_RS10895
• Protein ID: WP_012175536.1
• Coordinates: 2574812..2575093 (-)
• Length: 94 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DOLE_RS10875	2570684..2571016	+	333	WP_012175532.1	DUF1820 family protein	-
DOLE_RS10880	2571066..2572307	+	1242	WP_012175533.1	nucleoside:proton symporter	-
DOLE_RS10885	2572650..2574491	-	1842	WP_012175534.1	AMP-binding protein	-
DOLE_RS10890	2574519..2574815	-	297	WP_012175535.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DOLE_RS10895	2574812..2575093	-	282	WP_012175536.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DOLE_RS10900	2575505..2576485	+	981	WP_012175537.1	radical SAM domain-containing protein	-
DOLE_RS10905	2576789..2578267	+	1479	WP_012175538.1	30S ribosomal protein S1	-
DOLE_RS10910	2578326..2578805	+	480	WP_012175539.1	CBS domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-90)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-77)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11258.00 Da
• Isoelectric Point: 9.4813

>T22511 WP_012175535.1 NC_009943:c2574815-2574519 [Desulfococcus oleovorans Hxd3]
MKIVWSPLAVERASEIADYISQDKPAAATNWINVLFSKVDQLRANPEIGRIVPEINDRQFRELIYGNYRIIYHIGAKQIS
ILTVRHGRQILPTDEIKA

Nucleotide

• Length: 297 bp

>T22511 NC_009943:c2574815-2574519 [Desulfococcus oleovorans Hxd3]
ATGAAAATCGTATGGTCTCCCCTTGCTGTTGAAAGGGCATCAGAAATCGCGGACTACATTTCACAGGACAAGCCCGCGGC
GGCGACCAATTGGATTAATGTATTGTTTTCAAAAGTCGATCAGCTCCGGGCGAACCCGGAAATCGGGCGGATCGTTCCTG
AAATAAATGATCGTCAGTTCAGGGAGTTGATTTACGGCAACTATCGCATCATCTATCACATCGGCGCAAAACAGATATCC
ATACTTACGGTTCGGCATGGCAGGCAGATATTGCCGACAGATGAAATCAAGGCATAG

Antitoxin

Protein

• Length: 94 a.a.
• Molecular weight: 10261.94 Da
• Isoelectric Point: 10.4819

>AT22511 WP_012175536.1 NC_009943:c2575093-2574812 [Desulfococcus oleovorans Hxd3]
MQKLKIDQDIRSMSEVRNALASYIKQVHDTRRPVVITQHGKGVAVLLGANEFEAMQEKIDLLSDVQSALSQLAKGEGLSH
QKAKAGLLKRVPK

Nucleotide

• Length: 282 bp

>AT22511 NC_009943:c2575093-2574812 [Desulfococcus oleovorans Hxd3]
ATGCAAAAGCTTAAAATCGATCAGGACATCAGGTCAATGTCGGAAGTCCGAAATGCCCTGGCGTCTTATATCAAACAGGT
CCATGACACCAGGCGTCCGGTGGTCATTACGCAGCACGGCAAAGGTGTGGCCGTGCTTTTGGGGGCAAATGAGTTTGAAG
CCATGCAGGAAAAAATTGACCTTCTTTCAGATGTCCAATCCGCTCTCAGTCAACTGGCAAAAGGAGAAGGCCTTTCCCAC
CAGAAGGCAAAAGCCGGTTTGTTGAAGCGAGTTCCCAAATGA

Structures

Toxin

• AlphaFold DB: A8ZTZ0

Antitoxin

• AlphaFold DB: A8ZTZ1