Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 5425694..5426358 Replicon chromosome
Accession NZ_CP087197
Organism Pseudomonas sp. B21-012

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOY37_RS24975 Protein ID WP_258717225.1
Coordinates 5426185..5426358 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOY37_RS24970 Protein ID WP_258715937.1
Coordinates 5425694..5426116 (-) Length 141 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY37_RS24960 (LOY37_24935) 5421643..5425386 + 3744 WP_258715936.1 EAL domain-containing protein -
LOY37_RS24970 (LOY37_24945) 5425694..5426116 - 423 WP_258715937.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOY37_RS24975 (LOY37_24950) 5426185..5426358 - 174 WP_258717225.1 type II toxin-antitoxin system HicA family toxin Toxin
LOY37_RS24980 (LOY37_24955) 5426426..5427214 - 789 WP_258715938.1 helix-turn-helix transcriptional regulator -
LOY37_RS24985 (LOY37_24960) 5427308..5428126 + 819 WP_258715939.1 3-methyl-2-oxobutanoate hydroxymethyltransferase -
LOY37_RS24990 (LOY37_24965) 5428219..5428680 + 462 WP_038998420.1 Lrp/AsnC family transcriptional regulator -
LOY37_RS24995 (LOY37_24970) 5428799..5429137 + 339 WP_258715940.1 toxin -
LOY37_RS25000 (LOY37_24975) 5429139..5429453 + 315 WP_258608324.1 transcriptional regulator -
LOY37_RS25005 (LOY37_24980) 5429614..5431296 + 1683 WP_045199243.1 NAD(P)/FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(12-56)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6115.10 Da        Isoelectric Point: 11.0527

>T225106 WP_258717225.1 NZ_CP087197:c5426358-5426185 [Pseudomonas sp. B21-012]
VRPGKPISVYGVYDVGAKGSHHQFKHPTKSGRVTVPHPKSDIPKGTLNNILKTAGLK

Download         Length: 174 bp

>T225106 NZ_CP120970:2671150-2671404 [Moellerella wisconsensis]
GTGAAGCTAACATGGTCTGCCGAAGCATGGGAAGATTACTTGTACTGGCAAGAAACGGACAGAAAAACCGTAAAAAAGAT
AAATGAGCTCATTAAGAATGCCAGTAGAACACCATTTGAAGGAAAAGGTAAACCTGAACCTCTGAAACACAATCTTGCTG
GGTTCTGGTCACGAAGAATTACGGCGGAACATCGATTAGTCTATGCCGTTAGTAATGATTCCTTGCTAATAGCATCATGT
CGTTATCACTACTGA

Antitoxin


Download         Length: 141 a.a.        Molecular weight: 15330.13 Da        Isoelectric Point: 4.3221

>AT225106 WP_258715937.1 NZ_CP087197:c5426116-5425694 [Pseudomonas sp. B21-012]
MKFPVVIHKDPESDYGVTVPDVAGCFSAGETVEEALDNVQEALALHFESLVTDEEPLPQGQAIDAHMGNPDYAGGVWAVV
DFDVTPYLGKSVRFNASLPEFLLQRIDNYVKNHPEQKSRSGFLASAALRVLQETSPNVRT

Download         Length: 423 bp

>AT225106 NZ_CP120970:2670902-2671153 [Moellerella wisconsensis]
ATGAAAGCGGTAAGCTACAGTGAAGCCAGACAGAATTTATCAACAACAATGATTCAAACAGTTGAAGATAGAGTACCAGT
ACTGATCACGCGCCAGAATGGCGAATCATGTGTACTGATGTCTCTCGATGAATATAACTCTCTCGAAGAGACGGCATACC
TAATGAGATCACCAAAAAATGCACGCAGACTTATGGACTCGATAGAAAGCCTAAAAGATGGAAAAGGGATGGAAAGGGAA
ATTATTAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References