Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3089214..3089835 Replicon chromosome
Accession NZ_CP087197
Organism Pseudomonas sp. B21-012

Toxin (Protein)


Gene name hicA Uniprot ID A0A2G8MXB6
Locus tag LOY37_RS14105 Protein ID WP_016715573.1
Coordinates 3089214..3089396 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOY37_RS14110 Protein ID WP_045194468.1
Coordinates 3089434..3089835 (+) Length 134 a.a.

Genomic Context

LOY37_RS14080LOY37_RS14105LOY37_RS14110LOY37_RS14070LOY37_RS14075LOY37_RS14085LOY37_RS14090LOY37_RS14095LOY37_RS14100LOY37_RS14115LOY37_RS14120LOY37_RS14125LOY37_RS14130LOY37_RS14135LOY37_RS14140LOY37_RS14145LOY37_RS14150LOY37_RS14155LOY37_RS14160
Location: 3086978..3087382 (405 bp)
Type: Others
Protein ID: WP_258715006.1
Location: 3089214..3089396 (183 bp)
Type: Toxin
Protein ID: WP_016715573.1
Location: 3089434..3089835 (402 bp)
Type: Antitoxin
Protein ID: WP_045194468.1
Location: 3084811..3086301 (1491 bp)
Type: Others
Protein ID: WP_258715005.1
Location: 3086305..3086904 (600 bp)
Type: Others
Protein ID: WP_045194460.1
Location: 3087433..3087855 (423 bp)
Type: Others
Protein ID: WP_258715007.1
Location: 3087852..3088067 (216 bp)
Type: Others
Protein ID: WP_258715008.1
Location: 3088121..3088453 (333 bp)
Type: Others
Protein ID: WP_045194464.1
Location: 3088522..3089088 (567 bp)
Type: Others
Protein ID: WP_258715009.1
Location: 3089996..3090667 (672 bp)
Type: Others
Protein ID: WP_258715010.1
Location: 3090664..3090810 (147 bp)
Type: Others
Protein ID: WP_258715011.1
Location: 3090807..3091403 (597 bp)
Type: Others
Protein ID: WP_258715012.1
Location: 3091400..3091561 (162 bp)
Type: Others
Protein ID: WP_258715013.1
Location: 3091558..3092004 (447 bp)
Type: Others
Protein ID: WP_258715014.1
Location: 3091997..3092257 (261 bp)
Type: Others
Protein ID: WP_258715015.1
Location: 3092250..3092471 (222 bp)
Type: Others
Protein ID: WP_258715016.1
Location: 3092471..3093265 (795 bp)
Type: Others
Protein ID: WP_258715017.1
Location: 3093255..3094052 (798 bp)
Type: Others
Protein ID: WP_258717193.1
Location: 3094052..3094810 (759 bp)
Type: Others
Protein ID: WP_258715018.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LOY37_RS14070 (LOY37_14060)3084811..3086301-1491WP_258715005.1terminase-
LOY37_RS14075 (LOY37_14065)3086305..3086904-600WP_045194460.1hypothetical protein-
LOY37_RS14080 (LOY37_14070)3086978..3087382+405WP_258715006.1hypothetical protein-
LOY37_RS14085 (LOY37_14075)3087433..3087855-423WP_258715007.1proteasome subunit beta-
LOY37_RS14090 (LOY37_14080)3087852..3088067-216WP_258715008.1hypothetical protein-
LOY37_RS14095 (LOY37_14085)3088121..3088453-333WP_045194464.1phage holin, lambda family-
LOY37_RS14100 (LOY37_14090)3088522..3089088-567WP_258715009.1hypothetical protein-
LOY37_RS14105 (LOY37_14095)3089214..3089396+183WP_016715573.1type II toxin-antitoxin system HicA family toxinToxin
LOY37_RS14110 (LOY37_14100)3089434..3089835+402WP_045194468.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
LOY37_RS14115 (LOY37_14105)3089996..3090667-672WP_258715010.1hypothetical protein-
LOY37_RS14120 (LOY37_14110)3090664..3090810-147WP_258715011.1hypothetical protein-
LOY37_RS14125 (LOY37_14115)3090807..3091403-597WP_258715012.1recombination protein NinG-
LOY37_RS14130 (LOY37_14120)3091400..3091561-162WP_258715013.1hypothetical protein-
LOY37_RS14135 (LOY37_14125)3091558..3092004-447WP_258715014.1recombination protein NinB-
LOY37_RS14140 (LOY37_14130)3091997..3092257-261WP_258715015.1hypothetical protein-
LOY37_RS14145 (LOY37_14135)3092250..3092471-222WP_258715016.1hypothetical protein-
LOY37_RS14150 (LOY37_14140)3092471..3093265-795WP_258715017.1ATP-binding protein-
LOY37_RS14155 (LOY37_14145)3093255..3094052-798WP_258717193.1hypothetical protein-
LOY37_RS14160 (LOY37_14150)3094052..3094810-759WP_258715018.1phage antirepressor KilAC domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideProphage--3056251..311577859527


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6696.86 Da        Isoelectric Point: 11.2336

>T225105 WP_016715573.1 NZ_CP087197:3089214-3089396 [Pseudomonas sp. B21-012]
VQSRQLIKELEAAGWVLKRVTGSHHIFKHPNNPNSIPVPHPKKDLPIGTVKSIKERAGLK

Download         Length: 183 bp

>T225105 NZ_CP120970:2670902-2671153 [Moellerella wisconsensis]
ATGAAAGCGGTAAGCTACAGTGAAGCCAGACAGAATTTATCAACAACAATGATTCAAACAGTTGAAGATAGAGTACCAGT
ACTGATCACGCGCCAGAATGGCGAATCATGTGTACTGATGTCTCTCGATGAATATAACTCTCTCGAAGAGACGGCATACC
TAATGAGATCACCAAAAAATGCACGCAGACTTATGGACTCGATAGAAAGCCTAAAAGATGGAAAAGGGATGGAAAGGGAA
ATTATTAAGTGA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14582.52 Da        Isoelectric Point: 4.3588

>AT225105 WP_045194468.1 NZ_CP087197:3089434-3089835 [Pseudomonas sp. B21-012]
MQYPICIEWGDENTAIGIQVPDIPGAVTAGDTFEEAYTAAVEVAHIMLEEIASNGQAIPMPTTAATHRSNPDFADMGWGM
IEIDITPYLGKTEKVNVTLPGFVIQRIDRYVRDHNVKSRSSFLADAAMEKLGR

Download         Length: 402 bp

>AT225105 NZ_CP120970:2671150-2671404 [Moellerella wisconsensis]
GTGAAGCTAACATGGTCTGCCGAAGCATGGGAAGATTACTTGTACTGGCAAGAAACGGACAGAAAAACCGTAAAAAAGAT
AAATGAGCTCATTAAGAATGCCAGTAGAACACCATTTGAAGGAAAAGGTAAACCTGAACCTCTGAAACACAATCTTGCTG
GGTTCTGGTCACGAAGAATTACGGCGGAACATCGATTAGTCTATGCCGTTAGTAATGATTCCTTGCTAATAGCATCATGT
CGTTATCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A2G8MXB6

Antitoxin

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Source
ID
Structure
No matching records found

References