Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 1511069..1512762 | Replicon | chromosome |
| Accession | NZ_CP087197 | ||
| Organism | Pseudomonas sp. B21-012 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | - |
| Locus tag | LOY37_RS06950 | Protein ID | WP_258716528.1 |
| Coordinates | 1511893..1512762 (-) | Length | 290 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A1H1EW67 |
| Locus tag | LOY37_RS06945 | Protein ID | WP_045193445.1 |
| Coordinates | 1511069..1511896 (-) | Length | 276 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOY37_RS06925 (LOY37_06925) | 1506277..1507767 | - | 1491 | WP_258596940.1 | aldehyde dehydrogenase | - |
| LOY37_RS06930 (LOY37_06930) | 1507778..1508581 | - | 804 | WP_045193450.1 | aspartate dehydrogenase | - |
| LOY37_RS06935 (LOY37_06935) | 1508592..1510274 | - | 1683 | WP_258716526.1 | thiamine pyrophosphate-binding protein | - |
| LOY37_RS06940 (LOY37_06940) | 1510267..1511067 | - | 801 | WP_258716527.1 | SDR family oxidoreductase | - |
| LOY37_RS06945 (LOY37_06945) | 1511069..1511896 | - | 828 | WP_045193445.1 | IclR family transcriptional regulator | Antitoxin |
| LOY37_RS06950 (LOY37_06950) | 1511893..1512762 | - | 870 | WP_258716528.1 | alpha/beta hydrolase | Toxin |
| LOY37_RS06955 (LOY37_06955) | 1512767..1513306 | - | 540 | WP_093386119.1 | cupin domain-containing protein | - |
| LOY37_RS06960 (LOY37_06960) | 1513321..1514085 | - | 765 | WP_258716529.1 | SDR family oxidoreductase | - |
| LOY37_RS06965 (LOY37_06965) | 1514085..1514861 | - | 777 | WP_258716530.1 | ABC transporter permease | - |
| LOY37_RS06970 (LOY37_06970) | 1514891..1515889 | - | 999 | WP_258716531.1 | ABC transporter substrate-binding protein | - |
| LOY37_RS06975 (LOY37_06975) | 1515929..1516765 | - | 837 | WP_045193440.1 | ABC transporter ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 30748.05 Da Isoelectric Point: 7.0571
>T225104 WP_258716528.1 NZ_CP087197:c1512762-1511893 [Pseudomonas sp. B21-012]
MLHATDHSLAGLAAQLQQRFPQRLVQLASGAQAIREAGHGPAIVLLHGIGSGAASWLQVALQLSQHARVIAWDAPGYGDS
SPLANPAPQAVDYARRLRHLLDALQIDDCLLVGHSLGALSAAALTQQQPQRVRRLVLISPARGYGDPARAEQAQQVRSQR
LHSLEQLGIAQMANQRSAHMLSPAASSEARAWVQWNMARLLPQGYRQAIELLCGDDLLRYAALAVPYEVHCGAADSITRP
EDCQALAKALGAAFALIAEAGHASPIEQPEAVATLLARALEESLTGTAL
MLHATDHSLAGLAAQLQQRFPQRLVQLASGAQAIREAGHGPAIVLLHGIGSGAASWLQVALQLSQHARVIAWDAPGYGDS
SPLANPAPQAVDYARRLRHLLDALQIDDCLLVGHSLGALSAAALTQQQPQRVRRLVLISPARGYGDPARAEQAQQVRSQR
LHSLEQLGIAQMANQRSAHMLSPAASSEARAWVQWNMARLLPQGYRQAIELLCGDDLLRYAALAVPYEVHCGAADSITRP
EDCQALAKALGAAFALIAEAGHASPIEQPEAVATLLARALEESLTGTAL
Download Length: 870 bp
>T225104 NZ_CP120970:c2471036-2470626 [Moellerella wisconsensis]
GTGGTCCTGTGGAAATCTAATTTATCCATATCATGGATGGCTCAGCTTTTTTCTACCTGTGTACATTGTGTCCTGGGGCT
AGTGTTATTACTGGCTCCGTGGCCGACAGGTAACTCTATTATTTGGCTTCCTTTATTAATGGTGACTATTGCGAGTTGGG
CAAAAAGTCAAAAAAACATTAATAAATACAAAGGAATAATTGTTCTTACTAATGGGAATAAAGTCCAATGGAAGAAAAAT
GAATGGAGTATTATCACTCCTCCATGGTGTACTCGCTTTGGTATTTTATTAACGTTAAGTGCATTACAAGGTAAACCTAG
AAAAATAAAATTATGGATTGCAGCTGATGCAATATCAGAAGACGATTGGCGAAATTTAAATCAGTTATTATTACAATATC
CTGATATATAA
GTGGTCCTGTGGAAATCTAATTTATCCATATCATGGATGGCTCAGCTTTTTTCTACCTGTGTACATTGTGTCCTGGGGCT
AGTGTTATTACTGGCTCCGTGGCCGACAGGTAACTCTATTATTTGGCTTCCTTTATTAATGGTGACTATTGCGAGTTGGG
CAAAAAGTCAAAAAAACATTAATAAATACAAAGGAATAATTGTTCTTACTAATGGGAATAAAGTCCAATGGAAGAAAAAT
GAATGGAGTATTATCACTCCTCCATGGTGTACTCGCTTTGGTATTTTATTAACGTTAAGTGCATTACAAGGTAAACCTAG
AAAAATAAAATTATGGATTGCAGCTGATGCAATATCAGAAGACGATTGGCGAAATTTAAATCAGTTATTATTACAATATC
CTGATATATAA
Antitoxin
Download Length: 276 a.a. Molecular weight: 30416.81 Da Isoelectric Point: 6.3865
>AT225104 WP_045193445.1 NZ_CP087197:c1511896-1511069 [Pseudomonas sp. B21-012]
MNDSDLLKDNQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLELPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDHLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQHSPCTPKTVLELFDLVQSDRQRGYVSGEGFFESSISTIAAPVRDHSGRVVAAMGVTIPTVQVAHINF
DGLLGHVRGSADELSRLLNYTPNAGSGRVTALMRD
MNDSDLLKDNQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLELPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDHLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQHSPCTPKTVLELFDLVQSDRQRGYVSGEGFFESSISTIAAPVRDHSGRVVAAMGVTIPTVQVAHINF
DGLLGHVRGSADELSRLLNYTPNAGSGRVTALMRD
Download Length: 828 bp
>AT225104 NZ_CP120970:c2471283-2471017 [Moellerella wisconsensis]
ATGGATATTGATAATAAAGCGCGGATCCACTGGGCATGTCGTCGAGGAATGCGAGAACTAGATATTTCAATCATGCCTTT
TTTTGAACATGAGTATGATGGATTAAACGATAATGAAAAACACCAGTTTATTCGTTTGCTGGAGTGTGCAGATCCCGATC
TGTTCAATTGGTTGATGAACCATGGTCGTCCTGACGATGATGAGCTTTATCATATGATTAAACTAATTCAACAAAGAAAT
AAAGACCGTGGTCCTGTGGAAATCTAA
ATGGATATTGATAATAAAGCGCGGATCCACTGGGCATGTCGTCGAGGAATGCGAGAACTAGATATTTCAATCATGCCTTT
TTTTGAACATGAGTATGATGGATTAAACGATAATGAAAAACACCAGTTTATTCGTTTGCTGGAGTGTGCAGATCCCGATC
TGTTCAATTGGTTGATGAACCATGGTCGTCCTGACGATGATGAGCTTTATCATATGATTAAACTAATTCAACAAAGAAAT
AAAGACCGTGGTCCTGTGGAAATCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|