Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relE-PumB/upstrm_HI1419-dnstrm_HI1420 |
| Location | 974441..975035 | Replicon | chromosome |
| Accession | NZ_CP087197 | ||
| Organism | Pseudomonas sp. B21-012 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | - |
| Locus tag | LOY37_RS04390 | Protein ID | WP_045196177.1 |
| Coordinates | 974441..974734 (+) | Length | 98 a.a. |
Antitoxin (Protein)
| Gene name | PumB | Uniprot ID | A0A423E0C8 |
| Locus tag | LOY37_RS04395 | Protein ID | WP_045196178.1 |
| Coordinates | 974736..975035 (+) | Length | 100 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOY37_RS04365 (LOY37_04365) | 970226..971080 | + | 855 | WP_258716368.1 | putative selenate ABC transporter substrate-binding protein | - |
| LOY37_RS04370 (LOY37_04370) | 971077..971871 | + | 795 | WP_093388064.1 | ATP-binding cassette domain-containing protein | - |
| LOY37_RS04375 (LOY37_04375) | 971865..972692 | + | 828 | WP_213602383.1 | ABC transporter permease | - |
| LOY37_RS04380 (LOY37_04380) | 972689..973456 | + | 768 | WP_045196173.1 | phosphonate ABC transporter, permease protein PhnE | - |
| LOY37_RS04385 (LOY37_04385) | 973471..974136 | - | 666 | WP_093388073.1 | hypothetical protein | - |
| LOY37_RS04390 (LOY37_04390) | 974441..974734 | + | 294 | WP_045196177.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LOY37_RS04395 (LOY37_04395) | 974736..975035 | + | 300 | WP_045196178.1 | putative addiction module antidote protein | Antitoxin |
| LOY37_RS04400 (LOY37_04400) | 975171..975647 | - | 477 | WP_258716369.1 | GNAT family N-acetyltransferase | - |
| LOY37_RS04405 (LOY37_04405) | 975785..976297 | + | 513 | WP_093388085.1 | superoxide dismutase family protein | - |
| LOY37_RS04410 (LOY37_04410) | 976370..976675 | + | 306 | WP_045196588.1 | HigA family addiction module antitoxin | - |
| LOY37_RS04415 (LOY37_04415) | 977839..978513 | + | 675 | WP_258596490.1 | site-specific integrase | - |
| LOY37_RS04420 (LOY37_04420) | 979354..979587 | + | 234 | WP_258596492.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 98 a.a. Molecular weight: 10655.39 Da Isoelectric Point: 10.9839
>T225103 WP_045196177.1 NZ_CP087197:974441-974734 [Pseudomonas sp. B21-012]
MKYSVLQTPRFTSWLVSVRDLRARLAIARRIERATAGNLGDVKSVGGQVSEMRIDVGAGYRVYFTVRDGMVIVLLAGGDK
SSQSADIQLARKLAKEI
MKYSVLQTPRFTSWLVSVRDLRARLAIARRIERATAGNLGDVKSVGGQVSEMRIDVGAGYRVYFTVRDGMVIVLLAGGDK
SSQSADIQLARKLAKEI
Download Length: 294 bp
>T225103 NZ_CP120969:c4036055-4035618 [Pseudomonas putida]
GTGATTTTGTGGCGAATCAGCGCCTATGCAGACTTGAGTGGTACGGGGGGCTTGCGTGTAAGTGGCCGCTGGCACCAGGC
GGGGCGGCCGGTGGTGTATGCCGCCACCAGCCCTCCCGGGGCGATGCTGGAAGTGTTGGTGCACCTGGAGATCGACCCCG
AGGATTTCCCGACCATCATGCGCTTGCTTCGCATCGAACTGCCCGACACGGTTTCCCAGGCGCAGTTGCCCGCTTTGCAG
CCTGGCTGGTCTGCTCAGCCTGAGTTGACCCGTACGCTGGGCAATCGCTTTCTGGATGACGGTTCGGCATTGCTGCTGCC
GGTGCCAAGCGCGATCATGCCCAGCACCACCAATTACCTGTTCAACCCACGGCACCCGCAGGCGCAGAGCGCGAAAATCC
AGGTTGAGGATTTCACCCCGGACAGCCGCCTGTTCTAG
GTGATTTTGTGGCGAATCAGCGCCTATGCAGACTTGAGTGGTACGGGGGGCTTGCGTGTAAGTGGCCGCTGGCACCAGGC
GGGGCGGCCGGTGGTGTATGCCGCCACCAGCCCTCCCGGGGCGATGCTGGAAGTGTTGGTGCACCTGGAGATCGACCCCG
AGGATTTCCCGACCATCATGCGCTTGCTTCGCATCGAACTGCCCGACACGGTTTCCCAGGCGCAGTTGCCCGCTTTGCAG
CCTGGCTGGTCTGCTCAGCCTGAGTTGACCCGTACGCTGGGCAATCGCTTTCTGGATGACGGTTCGGCATTGCTGCTGCC
GGTGCCAAGCGCGATCATGCCCAGCACCACCAATTACCTGTTCAACCCACGGCACCCGCAGGCGCAGAGCGCGAAAATCC
AGGTTGAGGATTTCACCCCGGACAGCCGCCTGTTCTAG
Antitoxin
Download Length: 100 a.a. Molecular weight: 10589.14 Da Isoelectric Point: 6.4788
>AT225103 WP_045196178.1 NZ_CP087197:974736-975035 [Pseudomonas sp. B21-012]
MSLSLTTFDMAALLDSDEAISEYLSQVLADGDHDELIRALGHIAKARGMSQIASASGLGRESLYKALTPGAKPRFDTVLK
VIRALGIDLLAHPHTSSRL
MSLSLTTFDMAALLDSDEAISEYLSQVLADGDHDELIRALGHIAKARGMSQIASASGLGRESLYKALTPGAKPRFDTVLK
VIRALGIDLLAHPHTSSRL
Download Length: 300 bp
>AT225103 NZ_CP120969:c4036501-4036052 [Pseudomonas putida]
ATGCTTGCCGAAGTGCTTCGCGACAACGGTTACCACGAGTACCGGGCGCGCTTGCAGGCGCTGCTGGACATTCCCGAGCT
TGCCAGTGACTTCGAGATTCACACCCGCATCACCGATGGTTTTGCCGCCACCTGGTTGGTAAAGCTGACCGAACGCGGTG
TGCTCACGCCGGTGGAGCGCGACCAGATCATCCCGCTGCGCACCCTCAAATCCCGTATCGAGCGCGACCAACCGCTGACC
GTGGATGAGAGCGATCGGCTGTTCCGTTCGGCCCACATCACCGCCATGGCCGAGGCCGTGTTTGGTGAAGCGGGCAAGGC
CAAACGCTGGCTTTCCAAGCCCAAGGAGCGTTTCTCGGGGCTGACGCCGATGCAGATGCTCACCACCCAGCAAGGCACCA
CGCAGGTCGAAGAAATGCTGCTGCAGATTGCCGAGGGCTATGGCCTGTGA
ATGCTTGCCGAAGTGCTTCGCGACAACGGTTACCACGAGTACCGGGCGCGCTTGCAGGCGCTGCTGGACATTCCCGAGCT
TGCCAGTGACTTCGAGATTCACACCCGCATCACCGATGGTTTTGCCGCCACCTGGTTGGTAAAGCTGACCGAACGCGGTG
TGCTCACGCCGGTGGAGCGCGACCAGATCATCCCGCTGCGCACCCTCAAATCCCGTATCGAGCGCGACCAACCGCTGACC
GTGGATGAGAGCGATCGGCTGTTCCGTTCGGCCCACATCACCGCCATGGCCGAGGCCGTGTTTGGTGAAGCGGGCAAGGC
CAAACGCTGGCTTTCCAAGCCCAAGGAGCGTTTCTCGGGGCTGACGCCGATGCAGATGCTCACCACCCAGCAAGGCACCA
CGCAGGTCGAAGAAATGCTGCTGCAGATTGCCGAGGGCTATGGCCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|