Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 5068730..5069353 | Replicon | chromosome |
| Accession | NZ_CP087194 | ||
| Organism | Pseudomonas sp. B21-017 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | J3GAV2 |
| Locus tag | LOY28_RS22865 | Protein ID | WP_007984690.1 |
| Coordinates | 5068730..5068909 (+) | Length | 60 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A2W7JPN3 |
| Locus tag | LOY28_RS22870 | Protein ID | WP_064619786.1 |
| Coordinates | 5068946..5069353 (+) | Length | 136 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOY28_RS22845 (LOY28_22810) | 5063840..5064526 | - | 687 | WP_258612586.1 | cytochrome c oxidase subunit 3 | - |
| LOY28_RS22850 (LOY28_22815) | 5064523..5066298 | - | 1776 | WP_204124984.1 | cytochrome c oxidase subunit I | - |
| LOY28_RS22855 (LOY28_22820) | 5066347..5067819 | - | 1473 | WP_026286475.1 | cytochrome c oxidase subunit II | - |
| LOY28_RS22860 (LOY28_22825) | 5068128..5068463 | + | 336 | WP_018926814.1 | hypothetical protein | - |
| LOY28_RS22865 (LOY28_22830) | 5068730..5068909 | + | 180 | WP_007984690.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LOY28_RS22870 (LOY28_22835) | 5068946..5069353 | + | 408 | WP_064619786.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LOY28_RS22875 (LOY28_22840) | 5069405..5070175 | - | 771 | WP_258612587.1 | trans-aconitate 2-methyltransferase | - |
| LOY28_RS22880 (LOY28_22845) | 5070247..5070576 | - | 330 | WP_018926816.1 | YXWGXW repeat-containing protein | - |
| LOY28_RS22885 (LOY28_22850) | 5071017..5071520 | + | 504 | WP_258612588.1 | inclusion body family protein | - |
| LOY28_RS22890 (LOY28_22855) | 5071648..5072187 | + | 540 | WP_086944820.1 | AidA/PixA family protein | - |
| LOY28_RS22895 (LOY28_22860) | 5072272..5072802 | - | 531 | WP_225603008.1 | Lrp/AsnC family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 60 a.a. Molecular weight: 6704.97 Da Isoelectric Point: 11.4113
>T225098 WP_007984690.1 NZ_CP087194:5068730-5068909 [Pseudomonas sp. B21-017]
VNSRFLISQIVADGWYLVRIRGSHHHFKHPTKPGLVTVPHPKKDLLKKTAISILQQALL
VNSRFLISQIVADGWYLVRIRGSHHHFKHPTKPGLVTVPHPKKDLLKKTAISILQQALL
Download Length: 180 bp
>T225098 NZ_CP120969:340026-340502 [Pseudomonas putida]
TTGACGGGCATCAATCCATTGGCGATCGCCAGGTCACCGTACATCGCGCATCCAGATATCTGGTTGACAGATATCTGGAT
CAGAGATATTTTCCACCCTATGTTGGTGCGCCGGGACAACACAATGCGGGTCATAACGAAAGCGGCGGTAACCAAGGCGA
TTGAAGCCCACGGCCAGTGGAAAGCGCCCCTAAGCTTGTGGCTGACGACCTTCGACAGGGCGACGCTGCGGTTTGAATCT
TTTGAACAGTTGAGGCAGACGTGGGTCACTGTGTCTGGCTGGAGTGTTGATCGCATCCCCCACTCAGAACTTAGGCCCGC
CAGCCGCAAAGGGCCGCTTGATATCTACGTGTTCGATATCAAGAAAAACGAATGCCGCCTGATCGCGTGGCTCAATGCGC
GAACGGGCACTCTCTACATCAAGGCCATTCTGTCGCACGCCGAGTACGACAAATGGTGCAGAAGCGATATCAGGTAG
TTGACGGGCATCAATCCATTGGCGATCGCCAGGTCACCGTACATCGCGCATCCAGATATCTGGTTGACAGATATCTGGAT
CAGAGATATTTTCCACCCTATGTTGGTGCGCCGGGACAACACAATGCGGGTCATAACGAAAGCGGCGGTAACCAAGGCGA
TTGAAGCCCACGGCCAGTGGAAAGCGCCCCTAAGCTTGTGGCTGACGACCTTCGACAGGGCGACGCTGCGGTTTGAATCT
TTTGAACAGTTGAGGCAGACGTGGGTCACTGTGTCTGGCTGGAGTGTTGATCGCATCCCCCACTCAGAACTTAGGCCCGC
CAGCCGCAAAGGGCCGCTTGATATCTACGTGTTCGATATCAAGAAAAACGAATGCCGCCTGATCGCGTGGCTCAATGCGC
GAACGGGCACTCTCTACATCAAGGCCATTCTGTCGCACGCCGAGTACGACAAATGGTGCAGAAGCGATATCAGGTAG
Antitoxin
Download Length: 136 a.a. Molecular weight: 14676.66 Da Isoelectric Point: 4.3833
>AT225098 WP_064619786.1 NZ_CP087194:5068946-5069353 [Pseudomonas sp. B21-017]
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGEDLDDAMAMAREAIEGHFEILAEDGSPIPPANKVTLHAANPQYAGCTWAV
VDIDITKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQS
MLYPIAISMGDDEHAWGVEVPDIPGCFSAGEDLDDAMAMAREAIEGHFEILAEDGSPIPPANKVTLHAANPQYAGCTWAV
VDIDITKYLGKAQKLNITLPGYLLNRIDEYVLHHPEEKSRSGFLASAALKVLQQS
Download Length: 408 bp
>AT225098 NZ_CP120969:340544-341017 [Pseudomonas putida]
ATGAAGCGGGATAAAATTGAAGCCAATGGACTAGATGCCTTCATCGCTAATATTTCACCCATGCTCGATGGCCTGAACAC
TCAGATGGCAACCATGGCCCAGCTTCTAGCCGCCTGCCATGACCCCATCAAGGACGATGCCGAGCTTGAGGCACGCATGG
CATTGATCGACGAGCTCTACTCCCATGCGGACAGCGAAGGCCACGCTGCGGCACGCTTTGCCGAGATGGTAGCGGACCGC
GTCTACGAGTATGAGAGTGAGTCTGTATTGGTGCCGTTCGCGAGCCAGGCCGAAGCGTTGGCCTTTCTGCTGTCGGACAG
GGGCGTGAAGCAGAAGGACCTGTCGGCGATAGCGACCCAGAGCGCGGTATCCGAGATTCTGAACAACAAGCGGAAGATGA
CGGTTGCCCAGATAAAGGGCTTTGCTGAGTTTTTCAGCGTACCGGTTGAGTTCTTCATGCATGGGGTGGTTTGA
ATGAAGCGGGATAAAATTGAAGCCAATGGACTAGATGCCTTCATCGCTAATATTTCACCCATGCTCGATGGCCTGAACAC
TCAGATGGCAACCATGGCCCAGCTTCTAGCCGCCTGCCATGACCCCATCAAGGACGATGCCGAGCTTGAGGCACGCATGG
CATTGATCGACGAGCTCTACTCCCATGCGGACAGCGAAGGCCACGCTGCGGCACGCTTTGCCGAGATGGTAGCGGACCGC
GTCTACGAGTATGAGAGTGAGTCTGTATTGGTGCCGTTCGCGAGCCAGGCCGAAGCGTTGGCCTTTCTGCTGTCGGACAG
GGGCGTGAAGCAGAAGGACCTGTCGGCGATAGCGACCCAGAGCGCGGTATCCGAGATTCTGAACAACAAGCGGAAGATGA
CGGTTGCCCAGATAAAGGGCTTTGCTGAGTTTTTCAGCGTACCGGTTGAGTTCTTCATGCATGGGGTGGTTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | J3GAV2 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2W7JPN3 |