Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 4155024..4155628 Replicon chromosome
Accession NZ_CP087194
Organism Pseudomonas sp. B21-017

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LOY28_RS18755 Protein ID WP_018925564.1
Coordinates 4155024..4155317 (+) Length 98 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LOY28_RS18760 Protein ID WP_018925563.1
Coordinates 4155320..4155628 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY28_RS18735 (LOY28_18720) 4150175..4152094 + 1920 WP_258612355.1 hypothetical protein -
LOY28_RS18740 (LOY28_18725) 4152126..4153349 + 1224 WP_258612356.1 GNAT family N-acetyltransferase -
LOY28_RS18745 (LOY28_18730) 4153321..4154133 + 813 WP_204124066.1 ChbG/HpnK family deacetylase -
LOY28_RS18750 (LOY28_18735) 4154191..4154880 + 690 WP_018925565.1 hypothetical protein -
LOY28_RS18755 (LOY28_18740) 4155024..4155317 + 294 WP_018925564.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOY28_RS18760 (LOY28_18745) 4155320..4155628 + 309 WP_018925563.1 putative addiction module antidote protein Antitoxin
LOY28_RS18765 (LOY28_18750) 4155643..4156455 - 813 WP_018925562.1 class I SAM-dependent methyltransferase -
LOY28_RS18770 (LOY28_18755) 4156570..4157451 - 882 WP_064618753.1 LysR family transcriptional regulator -
LOY28_RS18775 (LOY28_18760) 4157612..4158628 + 1017 WP_018925560.1 alpha/beta hydrolase -
LOY28_RS18780 (LOY28_18765) 4158692..4160119 + 1428 WP_258612357.1 mechanosensitive ion channel family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-96)

Antitoxin

Uncharacterized protein HI1420

(5-91)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 10691.33 Da        Isoelectric Point: 10.9839

>T225095 WP_018925564.1 NZ_CP087194:4155024-4155317 [Pseudomonas sp. B21-017]
MNYLIQQTTIFVAWHASIRDLRAKVAIARRIDRASTGNLGDIKSVGDGVSEMRVDVGAGYRVYFTLRNGVVIVLLAGGDK
SSQNTDIRRAKKLAREV

Download         Length: 294 bp

>T225095 NZ_CP120958:243221-243571 [Bacillus cereus]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCAACGGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTACGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAGCGCTTAACGGACAAAATCACTCACTTAGATGAAGTGATGATGATTCGTGTAGATGAAGCGCT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 10913.43 Da        Isoelectric Point: 5.0344

>AT225095 WP_018925563.1 NZ_CP087194:4155320-4155628 [Pseudomonas sp. B21-017]
MGQTLTAFDMAALLDSDEAISEYLSQVLADGDNEEFLRAIGYVVKARGMTQIAKDSGMGRESLYKAFAPGAKPRFDTVLK
VIHALGIDLCAQPGHAANHSTL

Download         Length: 309 bp

>AT225095 NZ_CP120958:242929-243216 [Bacillus cereus]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAATTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References