Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 251290..251933 Replicon chromosome
Accession NZ_CP087194
Organism Pseudomonas sp. B21-017

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOY28_RS01085 Protein ID WP_018929327.1
Coordinates 251290..251472 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOY28_RS01090 Protein ID WP_008005174.1
Coordinates 251469..251933 (+) Length 155 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY28_RS01065 (LOY28_01065) 247112..249067 + 1956 WP_204124005.1 choline transporter BetT -
LOY28_RS01070 (LOY28_01070) 249082..249342 - 261 WP_018929330.1 hypothetical protein -
LOY28_RS01075 (LOY28_01075) 249405..250145 - 741 WP_019651514.1 SDR family oxidoreductase -
LOY28_RS01080 (LOY28_01080) 250271..251161 + 891 WP_018929328.1 LysR family transcriptional regulator -
LOY28_RS01085 (LOY28_01085) 251290..251472 + 183 WP_018929327.1 type II toxin-antitoxin system HicA family toxin Toxin
LOY28_RS01090 (LOY28_01090) 251469..251933 + 465 WP_008005174.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOY28_RS01095 (LOY28_01095) 252100..253137 + 1038 WP_018929326.1 L-glyceraldehyde 3-phosphate reductase -
LOY28_RS01100 (LOY28_01100) 253191..254033 - 843 WP_258612951.1 taurine dioxygenase -
LOY28_RS01105 (LOY28_01105) 254073..254921 - 849 WP_018929324.1 taurine ABC transporter permease TauC -
LOY28_RS01110 (LOY28_01110) 254918..255712 - 795 WP_018929323.1 taurine ABC transporter ATP-binding subunit -
LOY28_RS01115 (LOY28_01115) 255729..256706 - 978 WP_258612952.1 taurine ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(24-148)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6873.01 Da        Isoelectric Point: 10.3203

>T225093 WP_018929327.1 NZ_CP087194:251290-251472 [Pseudomonas sp. B21-017]
MRSREMIRMIEEDGWYLVAVKGSHHQYKHPCKSGRVTIKHPDSDLPKGTINSILKQAGLK

Download         Length: 183 bp

>T225093 NZ_CP120956:5850338-5850718 [Delftia tsuruhatensis]
ATGAATCCCGTTCTGGTCGATACCTCGGTCTGGATCGATCACTTCAGGCAGGGCAATCCTCACCTGGCGCAGTTGCTGCA
GCAAGACATGGCGCTCATGCATCCCCTGGTGCTGGGTGAACTGGCTTGCGGCACGCCACCGGCACGCGCACGCACGCTCG
CGGACCTTCAGCGGCTCAAGCCTGCCCGACAGGCCAGCATGCGCGAAGTGCTGGCCTTGATAGAGCGCGAGCAACTCTTT
GGTCTGGGCTGCGGTCTGGTGGACATCACGCTCCTGGCCTCGGCACTCATGTCTTCAGGCGCCAGCCTGTGGTCGCTGGA
CAAACGCCTGCACGCGCTGGCCCAGCGGTTTGGCATTGCCTGCCGGAGCGTCTTGCCGTAG

Antitoxin


Download         Length: 155 a.a.        Molecular weight: 16808.81 Da        Isoelectric Point: 4.2692

>AT225093 WP_008005174.1 NZ_CP087194:251469-251933 [Pseudomonas sp. B21-017]
MRPDIGNESLEGATSQEGLIEMKFPVVLHKDADSEYGVIIPDVPGCFSAGATVAQAFENVKEALALHYEGLVADGDPLPQ
VREIDAHLDNPDYAGGVWGVVEFDITPYFGKSVRFNATLPEQLLERIDQTVRRDQRYSSRSGFLAAAALRELSA

Download         Length: 465 bp

>AT225093 NZ_CP120956:5850138-5850341 [Delftia tsuruhatensis]
ATGAGAACCACGGTCACCATCGACGACGCCTTGTACGAGGAAGCGCTGGAGCTGGCGGAGCCAGAAATGGACAAGGCCGA
CCTGTTTCGCGAAGCCATCAAGACTTTCGTGAGAGTGCAGGCGGCCAAGCGTCTGGCCGCGCTGGGAGGCTCCGCACCGG
ACATGCGGGAGATTCCCCGTCGCCCACAGGGCATCGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References