Detailed information of TA system TA225087

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 203592..204108
• Replicon: chromosome
• Accession: NZ_CP087192
• Organism: Pseudomonas sp. B21-021

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LOY31_RS00870
• Protein ID: WP_115076110.1
• Coordinates: 203827..204108 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A0C1VYZ2
• Locus tag: LOY31_RS00865
• Protein ID: WP_039773014.1
• Coordinates: 203592..203837 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOY31_RS00830 (LOY31_00830)	198863..199468	+	606	WP_221535455.1	adenylyl-sulfate kinase	-
LOY31_RS00835 (LOY31_00835)	199465..200250	+	786	WP_221535456.1	aspartyl/asparaginyl beta-hydroxylase domain-containing protein	-
LOY31_RS00840 (LOY31_00840)	200238..201212	+	975	WP_221535457.1	sulfotransferase family protein	-
LOY31_RS00845 (LOY31_00845)	201178..201936	-	759	WP_007957673.1	slipin family protein	-
LOY31_RS00850 (LOY31_00850)	201939..202466	-	528	WP_221535458.1	NfeD family protein	-
LOY31_RS00855 (LOY31_00855)	202663..203124	+	462	WP_221535459.1	YbaK/EbsC family protein	-
LOY31_RS00860 (LOY31_00860)	203254..203496	+	243	WP_221535460.1	DUF2789 domain-containing protein	-
LOY31_RS00865 (LOY31_00865)	203592..203837	+	246	WP_039773014.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LOY31_RS00870 (LOY31_00870)	203827..204108	+	282	WP_115076110.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOY31_RS00875 (LOY31_00875)	204233..204661	+	429	WP_011331882.1	winged helix DNA-binding protein	-
LOY31_RS00880 (LOY31_00880)	204658..206721	+	2064	WP_221535461.1	FUSC family protein	-
LOY31_RS00885 (LOY31_00885)	206718..206927	+	210	WP_007957657.1	DUF1656 domain-containing protein	-
LOY31_RS00890 (LOY31_00890)	206924..207811	+	888	WP_007957655.1	HlyD family secretion protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-67)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10941.77 Da
• Isoelectric Point: 10.4588

>T225087 WP_115076110.1 NZ_CP087192:203827-204108 [Pseudomonas sp. B21-021]
MTYKLEFLPSAHKEWNKLGHTLRDQFKKKLAERLERPRIPADSLHGMPDCYKIKLKASGYRLVYQVIEERVVVSVVAVGK
RERGDVYENAKRR

Nucleotide

• Length: 282 bp

>T225087 NZ_CP120950:57041-57391 [Burkholderia contaminans]
ATGGTGAGGCGCGTCAAATTCGAGCGTGGCGATATCGTGCGCGTCAGCCTGAATCCCACGATAGGGAAGGAGCAACAAGG
GGATTTCCGGCCCGCGCTCGTTCTCTCGCCTGCTGCGTTCAACGCGCTCGGCGTGGCGCTCGTTGCACCGATCACGCAGG
GAGGCGAATTCGCGCGATATGCCGGATTCGCCGTGCCTCTCTCGGGTGCGGGAACTGAAACGCAGGGCGTGGCGCTTGTG
AACATGGTTCGCACGCTCGATCTTGAAGCGCGGGGTGCCCGCAAGGTTGAGCGCGCACCGGTCGAAGTTGTCGAAGATGC
GCTCGCTCGCCTGCAAACCATTTTGGAATAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8776.06 Da
• Isoelectric Point: 4.4988

>AT225087 WP_039773014.1 NZ_CP087192:203592-203837 [Pseudomonas sp. B21-021]
MQSVLADMAVSVSELKKNPSAVLNGAHGGAVAVLNHNRVMGYMVPADVYEAMMERLDDLELAEIVRSRSHETPIPVSLDD
L

Nucleotide

• Length: 246 bp

>AT225087 NZ_CP120950:56796-57047 [Burkholderia contaminans]
ATGGAACTAAAAATTCAGAAATGGGGTAACAGCGCGGCAGTCCGGCTGCCCGCTGTATTGCTGGAGCAGATCGGCGCATC
GGCAGGCAGTTCGCTGAACGCCGATGTGCGGCCCGATGGCGTGTTGCTGACGCCTGCTCGCCGTAAGTATTCGCTGGATG
AACTGGTCGCGCAGTGCGACCAGAATGCTCCGCAACCCGCTGACCTTGCTGCCTGGGTCGAAGCAAAGCCAGTGGGGCAT
GAAGCATGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0C1VYZ2