Detailed information of TA system TA225084

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 946698..947217
• Replicon: chromosome
• Accession: NZ_CP087190
• Organism: Pseudomonas sp. B21-023

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LOY42_RS04360
• Protein ID: WP_258599887.1
• Coordinates: 946698..946988 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LOY42_RS04365
• Protein ID: WP_203648016.1
• Coordinates: 946978..947217 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOY42_RS04345 (LOY42_04350)	945170..945310	+	141	WP_258599885.1	hypothetical protein	-
LOY42_RS04350 (LOY42_04355)	945303..945533	+	231	WP_102682137.1	hypothetical protein	-
LOY42_RS04355 (LOY42_04360)	945679..946331	-	653	Protein_847	hypothetical protein	-
LOY42_RS04360 (LOY42_04365)	946698..946988	-	291	WP_258599887.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOY42_RS04365 (LOY42_04370)	946978..947217	-	240	WP_203648016.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LOY42_RS04370 (LOY42_04375)	947309..948796	-	1488	WP_258599889.1	methylenetetrahydrofolate reductase C-terminal domain-containing protein	-
LOY42_RS04375 (LOY42_04380)	949098..951401	+	2304	WP_258599891.1	5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	-
LOY42_RS04380 (LOY42_04385)	951469..951987	+	519	WP_258599893.1	histidine phosphatase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	924805..947217	22412

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11392.25 Da
• Isoelectric Point: 10.2588

>T225084 WP_258599887.1 NZ_CP087190:c946988-946698 [Pseudomonas sp. B21-023]
MTYNLDFDARALKEWQKLGDTIRQQLKKKLATVLLNPRIEANRLHGFPDCYKIKLRSSGYRLVYQVIDHQIVVFVVAVDK
RERDQVYRKAAERLTE

Nucleotide

• Length: 291 bp

>T225084 NZ_CP120948:2366457-2366795 [Burkholderia contaminans]
ATGGTTGACATACTGCAATCCATGCCCTACAGTGCGCCTACGTTCAGCATCCGGACCACCGGCGTCTTCGACACCTGGTT
TGCCGGCCTGCAGGATCGCGTCGCGAAGCGCCGCATCCAGGCACGCATCGACCGCCTCTCGATGGGCAATCCGGGCGACT
GGAAGTCCGCCGGCTCGCCGGTCGTCGAGATGCGGATCGACCACGGCCCGGGCTATCGCGTCTACTACGTCCGGCGCGGA
ACGATCTGGGTCATCCTGCTCTGCGGCGGCGATAAATCGTCGCAACAGGCCGACATCCGCGCCGCGCACGCGATGCTCGC
GCATCTCGACATGGAGTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9034.45 Da
• Isoelectric Point: 4.8146

>AT225084 WP_203648016.1 NZ_CP087190:c947217-946978 [Pseudomonas sp. B21-023]
MASINVRIDDDLKVRAYRELEKLGVTPSELMRQALQYVAERGQLPFKPVLLTEEDEALLATVRERLAAPQRVRVTLDDL

Nucleotide

• Length: 240 bp

>AT225084 NZ_CP120948:2366799-2367098 [Burkholderia contaminans]
ATGGACAAGATCAGCACCCGGCCGTGGGATTCGGCCGATCATCTGAAAACCGAAGACGACATGGCCGACTACTTCGAAGC
GTGCCTGCAGGAAGCCGGCGACGATCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCGCGTGCACGCGGCATGTCGC
AGGTCGCGCGCGATGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAACCCCAGCTTCGGCACG
ATCCTGAAGGTCATCAAGGCGCTCGGCCTGCAACTGCACGGCTCGAAAGCGCACGCATGA