Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 304918..305539 Replicon chromosome
Accession NZ_CP087190
Organism Pseudomonas sp. B21-023

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOY42_RS01440 Protein ID WP_102681827.1
Coordinates 304918..305109 (+) Length 64 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOY42_RS01445 Protein ID WP_110697254.1
Coordinates 305126..305539 (+) Length 138 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY42_RS01420 (LOY42_01420) 300264..301322 + 1059 WP_139674302.1 putative 2-aminoethylphosphonate ABC transporter ATP-binding protein -
LOY42_RS01425 (LOY42_01425) 301324..303048 + 1725 WP_198755328.1 putative 2-aminoethylphosphonate ABC transporter permease subunit -
LOY42_RS01430 (LOY42_01430) 303079..304101 + 1023 WP_258599706.1 putative 2-aminoethylphosphonate ABC transporter substrate-binding protein -
LOY42_RS01435 (LOY42_01435) 304193..304738 + 546 WP_102681828.1 HDIG domain-containing protein -
LOY42_RS01440 (LOY42_01440) 304918..305109 + 192 WP_102681827.1 type II toxin-antitoxin system HicA family toxin Toxin
LOY42_RS01445 (LOY42_01445) 305126..305539 + 414 WP_110697254.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOY42_RS01450 (LOY42_01450) 305540..306919 - 1380 WP_258599707.1 ATP-binding protein -
LOY42_RS01455 (LOY42_01455) 306921..307640 - 720 WP_258599708.1 response regulator transcription factor -
LOY42_RS01460 (LOY42_01460) 307782..310076 + 2295 WP_258599709.1 TonB-dependent siderophore receptor -
LOY42_RS01465 (LOY42_01465) 310165..310416 + 252 WP_094010985.1 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 64 a.a.        Molecular weight: 7033.15 Da        Isoelectric Point: 10.4613

>T225083 WP_102681827.1 NZ_CP087190:304918-305109 [Pseudomonas sp. B21-023]
MNSREMIAVIEADGWYLVRSKGSHHHFKHPEKAGLVTIPHPKKDLLPATAASILRQARISYAS

Download         Length: 192 bp

>T225083 NZ_CP120948:c1599968-1599672 [Burkholderia contaminans]
ATGGAAAAGAGAACGCCTCATTGCAAGCTGCCTCGCGTCAAGGCACTCGTCGAAACCGGCCAGGTCCGGCTAACGGCGAG
TGCGGTACTCGGCGCCCGGCTATTGGGTTTCACGGAACGGGAGGCGCTCGATGTCGTGCTGTCGCTGACCGATCTCGACT
TCCACAAGAGCATGACGACGTACGCCGACCACACGATCTGGCAGGACGTCTACCGACCTTTCACGGTGCGTGGCGACGTG
TACCTGAAACTGACGGTGATCGACGATGTGCTGATCGTGTCTTTCAAGGAGCGATGA

Antitoxin


Download         Length: 138 a.a.        Molecular weight: 14901.93 Da        Isoelectric Point: 4.6025

>AT225083 WP_110697254.1 NZ_CP087190:305126-305539 [Pseudomonas sp. B21-023]
MLFPIAILPGDDQHAWGVEVPDIPGCFSAGEDLDDAIAMAREAIEGHLELLAQDQQEIPRASKVGVHAANPAYAGCTWAL
IDIDITRYLGKAEKLNITLPAYLLTRIDSYVQNHPEHKSRSGFLAEAALRILQGDGK

Download         Length: 414 bp

>AT225083 NZ_CP120948:c1599669-1599268 [Burkholderia contaminans]
ATGAAGTGCCCTGCATGCGGTGCCGCCAGGCTGGTCCGCGACACGCGAGACATCCCTTATACCTACAAGGGCCGGTCGAC
TGTCGTTCGCGACATCACCGGCGATTTCTGCCCGGCCTGCGGGGAATCGGTGCTGGATCTCGACGAGGCGACCCGTCTCG
GCGAAGCGATCACCGAATTCAACAAGCAGGTGAACGCCACCATCGTCGACCCGAAGTACATCGCGAAGGTGCGCAAGAAG
CTGAAGCTGGATCAGCGCGAGGCAGCCGAGCTCTTCGGCGGTGGAGTCAACGCGTTCTCCCGTTACGAAACGGGCAAGAC
GAATCCGCCGCTTGCCCTCGTGAAATTGCTGAAGCTCCTGGATCGTCACCCCGATCTGCTCGCCGAAGTTCGAGCGGCAT
AG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References