Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 2639022..2639611 Replicon chromosome
Accession NZ_CP087189
Organism Pseudomonas protegens strain B21-024

Toxin (Protein)


Gene name hicA Uniprot ID A0A7V8EXE5
Locus tag LOY29_RS12220 Protein ID WP_019094202.1
Coordinates 2639360..2639611 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOY29_RS12215 Protein ID WP_072451388.1
Coordinates 2639022..2639363 (-) Length 114 a.a.

Genomic Context

LOY29_RS12195LOY29_RS12200LOY29_RS12205LOY29_RS12235LOY29_RS12240LOY29_RS12245LOY29_RS12190LOY29_RS12210LOY29_RS12215LOY29_RS12220LOY29_RS12225LOY29_RS12230
Location: 2635588..2635989 (402 bp)
Type: Others
Protein ID: WP_225368747.1
Location: 2636033..2637067 (1035 bp)
Type: Others
Protein ID: WP_015635068.1
Location: 2637067..2638167 (1101 bp)
Type: Others
Protein ID: WP_258611733.1
Location: 2642291..2643061 (771 bp)
Type: Others
Protein ID: WP_015635071.1
Location: 2643122..2643778 (657 bp)
Type: Others
Protein ID: WP_011060581.1
Location: 2643775..2644521 (747 bp)
Type: Others
Protein ID: WP_011060582.1
Location: 2634369..2635325 (957 bp)
Type: Others
Protein ID: WP_015635066.1
Location: 2638220..2638561 (342 bp)
Type: Others
Protein ID: WP_053157594.1
Location: 2639022..2639363 (342 bp)
Type: Antitoxin
Protein ID: WP_072451388.1
Location: 2639360..2639611 (252 bp)
Type: Toxin
Protein ID: WP_019094202.1
Location: 2639699..2640754 (1056 bp)
Type: Others
Protein ID: WP_248766040.1
Location: 2641343..2642119 (777 bp)
Type: Others
Protein ID: WP_258611734.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LOY29_RS12190 (LOY29_12175)2634369..2635325-957WP_015635066.1nucleoside-specific channel-forming protein Tsx-
LOY29_RS12195 (LOY29_12180)2635588..2635989+402WP_225368747.1nuclear transport factor 2 family protein-
LOY29_RS12200 (LOY29_12185)2636033..2637067+1035WP_015635068.1selenide, water dikinase SelD-
LOY29_RS12205 (LOY29_12190)2637067..2638167+1101WP_258611733.1tRNA 2-selenouridine(34) synthase MnmH-
LOY29_RS12210 (LOY29_12195)2638220..2638561-342WP_053157594.1DUF3077 domain-containing protein-
LOY29_RS12215 (LOY29_12200)2639022..2639363-342WP_072451388.1type II toxin-antitoxin system HicB family antitoxinAntitoxin
LOY29_RS12220 (LOY29_12205)2639360..2639611-252WP_019094202.1type II toxin-antitoxin system HicA family toxinToxin
LOY29_RS12225 (LOY29_12210)2639699..2640754-1056WP_248766040.1permease-
LOY29_RS12230 (LOY29_12215)2641343..2642119-777WP_258611734.1IclR family transcriptional regulator-
LOY29_RS12235 (LOY29_12220)2642291..2643061+771WP_015635071.1ABC transporter substrate-binding protein-
LOY29_RS12240 (LOY29_12225)2643122..2643778+657WP_011060581.1amino acid ABC transporter permease-
LOY29_RS12245 (LOY29_12230)2643775..2644521+747WP_011060582.1amino acid ABC transporter ATP-binding protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-76)

Antitoxin

Uncharacterised protein family HicB

(55-105)


Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9239.70 Da        Isoelectric Point: 10.4707

>T225080 WP_019094202.1 NZ_CP087189:c2639611-2639360 [Pseudomonas protegens]
VSKNDKLLAKLLNDRGTFSWQELVTLLKRLGYTPLEGSGSRVKFDNGDPGAMINLHKPHPGNELKAYIRRQVIEQLKSGG
LIP

Download         Length: 252 bp

>T225080 NZ_CP087189:c2639611-2639360 [Pseudomonas protegens]
GTGTCCAAGAACGATAAGCTTCTCGCCAAGTTACTCAACGACCGAGGGACCTTTTCCTGGCAGGAACTGGTCACTCTCCT
AAAGCGCCTGGGCTACACACCGTTGGAGGGCTCGGGCAGCCGGGTAAAATTCGACAATGGTGATCCAGGCGCAATGATCA
ACCTGCACAAACCGCACCCCGGTAATGAGCTGAAGGCCTACATACGCCGCCAAGTGATCGAGCAACTGAAATCGGGAGGT
CTCATACCGTGA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12438.82 Da        Isoelectric Point: 4.8281

>AT225080 WP_072451388.1 NZ_CP087189:c2639363-2639022 [Pseudomonas protegens]
VNNLLQHKGYYGSIEVSTEDNCLFGKLQFIRALVSYEGQTVAELEAAFKEAVDDYLDTCEQSGTAPEIPCKGSFNVRVGH
DLHLAAAVAATRQNVSLNDLTRQALNEYLQHHG

Download         Length: 342 bp

>AT225080 NZ_CP087189:c2639363-2639022 [Pseudomonas protegens]
GTGAACAACCTACTGCAGCACAAGGGCTATTACGGCTCTATCGAGGTCAGTACCGAGGACAATTGCCTCTTTGGCAAACT
TCAGTTCATAAGGGCCTTGGTTAGCTATGAGGGGCAGACCGTGGCTGAACTCGAAGCGGCCTTCAAAGAGGCAGTAGACG
ACTATCTGGATACCTGTGAGCAATCGGGTACAGCACCCGAAATCCCTTGCAAAGGCTCGTTCAACGTTCGGGTAGGCCAC
GATCTTCATCTAGCGGCTGCCGTGGCCGCCACCCGGCAGAATGTATCGTTGAACGATCTGACTCGTCAGGCCCTGAATGA
ATACCTGCAACATCACGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7V8EXE5

Antitoxin

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Source
ID
Structure
No matching records found

References