Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 317542..318179 Replicon chromosome
Accession NZ_CP087188
Organism Pseudomonas laurylsulfatiphila strain B21-025

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOY25_RS01385 Protein ID WP_007983250.1
Coordinates 317542..317949 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LOY25_RS01390 Protein ID WP_258683132.1
Coordinates 317949..318179 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY25_RS01365 (LOY25_01365) 313204..313899 - 696 WP_007972786.1 ABC transporter permease -
LOY25_RS01370 (LOY25_01370) 313972..314721 - 750 WP_007972785.1 ABC transporter substrate-binding protein -
LOY25_RS01375 (LOY25_01375) 314735..315508 - 774 WP_007972784.1 ABC transporter ATP-binding protein -
LOY25_RS01380 (LOY25_01380) 316073..317464 + 1392 WP_015093062.1 GABA permease -
LOY25_RS01385 (LOY25_01385) 317542..317949 - 408 WP_007983250.1 tRNA(fMet)-specific endonuclease VapC Toxin
LOY25_RS01390 (LOY25_01390) 317949..318179 - 231 WP_258683132.1 antitoxin Antitoxin
LOY25_RS01395 (LOY25_01395) 318348..318803 - 456 WP_102700259.1 hypothetical protein -
LOY25_RS01400 (LOY25_01400) 318810..319226 - 417 WP_258683133.1 hypothetical protein -
LOY25_RS01405 (LOY25_01405) 319263..320237 - 975 WP_258683134.1 alpha/beta fold hydrolase -
LOY25_RS01410 (LOY25_01410) 320306..321364 - 1059 WP_258683135.1 PDDEXK nuclease domain-containing protein -
LOY25_RS01415 (LOY25_01415) 321619..322068 + 450 WP_218475742.1 carboxypeptidase regulatory-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15062.43 Da        Isoelectric Point: 6.9689

>T225070 WP_007983250.1 NZ_CP087188:c317949-317542 [Pseudomonas laurylsulfatiphila]
MIKYMLDTNICIFTIKNKPQAVREAFNRHHGQLCISAITLMELIYGAEKSAAPEKNLAVIEGFAARLEVLPFDNEAAAHT
GMIRSELAKAGTPIGPYDQMIAGHARSRGFIVVTNNLREFERVPGLRVEDWVHVE

Download         Length: 408 bp

>T225070 NZ_CP120944:c4609752-4609438 [Escherichia coli O157:H7 str. EDL933]
ATGCAATTTACGGTATACCGCAGTCGCAGCAGGAACGCCGCGTTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGTGATTAATCGCCGTATTGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8577.60 Da        Isoelectric Point: 4.3867

>AT225070 WP_258683132.1 NZ_CP087188:c318179-317949 [Pseudomonas laurylsulfatiphila]
MEQTTLFMSNRSQAVRLPKAVAMPSDVKRVDVVAVGRARIITPAGETWDSWFDGESVTADFMTDREQPAEQERESF

Download         Length: 231 bp

>AT225070 NZ_CP120944:c4609988-4609755 [Escherichia coli O157:H7 str. EDL933]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CTGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References