Detailed information of TA system TA022507

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-StbC
• Location: 4388956..4389629
• Replicon: chromosome
• Accession: NC_009937
• Organism: Azorhizobium caulinodans ORS 571

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A8IP70
• Locus tag: AZC_RS19730
• Protein ID: WP_012172360.1
• Coordinates: 4388956..4389378 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A8IP74
• Locus tag: AZC_RS19735
• Protein ID: WP_012172361.1
• Coordinates: 4389375..4389629 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
AZC_RS19700	4384387..4384638	-	252	WP_012172353.1	hypothetical protein	-
AZC_RS19705	4384635..4385288	-	654	WP_012172354.1	AAA family ATPase	-
AZC_RS19710	4385285..4386394	-	1110	WP_012172355.1	replication initiator protein A	-
AZC_RS19715	4386403..4386684	-	282	WP_012172356.1	helix-turn-helix domain-containing protein	-
AZC_RS19720	4386980..4387306	-	327	WP_012172357.1	DUF736 domain-containing protein	-
AZC_RS19725	4387937..4388377	-	441	WP_012172358.1	hypothetical protein	-
AZC_RS25870	4388506..4388673	-	168	WP_173362978.1	hypothetical protein	-
AZC_RS19730	4388956..4389378	-	423	WP_012172360.1	type II toxin-antitoxin system VapC family toxin	Toxin
AZC_RS19735	4389375..4389629	-	255	WP_012172361.1	plasmid stabilization protein	Antitoxin
AZC_RS19740	4389715..4390641	-	927	WP_012172362.1	DUF2493 domain-containing protein	-
AZC_RS19745	4390955..4392046	-	1092	WP_012172363.1	toprim domain-containing protein	-
AZC_RS19750	4392108..4394171	-	2064	WP_012172364.1	ParB/Srx family N-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	4346448..4397109	50661

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 15013.10 Da
• Isoelectric Point: 4.4408

>T22507 WP_012172360.1 NC_009937:c4389378-4388956 [Azorhizobium caulinodans ORS 571]
MILLDTNVISEAMKPAPEDNVRAWLDEQAAETLYLSSVTIAELLYGIGALPAGKRKDRLTEALDGVMELFADRVLPFDVA
AARRYADLAVQARTAGKGFPTPDGYIAAIAASRGFTVATRDTSAFDAAGVVVINPWNVDR

Nucleotide

• Length: 423 bp

>T22507 NC_009937:c4389378-4388956 [Azorhizobium caulinodans ORS 571]
ATGATCCTTCTCGACACCAATGTCATATCGGAGGCGATGAAGCCCGCGCCCGAAGACAACGTGCGGGCATGGCTCGACGA
GCAGGCGGCCGAGACGCTCTATCTCTCCAGCGTCACCATCGCCGAACTGTTGTACGGCATCGGTGCGCTACCCGCGGGCA
AGCGCAAGGACAGGCTCACCGAAGCCCTGGACGGGGTGATGGAGCTGTTCGCCGACCGCGTTCTGCCGTTCGATGTCGCT
GCCGCACGACGCTATGCCGACCTCGCCGTGCAAGCGCGCACGGCCGGGAAGGGCTTTCCGACGCCCGACGGCTATATCGC
CGCAATCGCAGCCTCCCGGGGCTTCACTGTGGCCACGCGCGATACCAGCGCGTTCGACGCCGCCGGTGTGGTGGTCATCA
ATCCGTGGAACGTGGACCGCTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9393.65 Da
• Isoelectric Point: 9.1399

>AT22507 WP_012172361.1 NC_009937:c4389629-4389375 [Azorhizobium caulinodans ORS 571]
MPAVTIRNLSEATHRALKVRAAQHGRSTEAEMRDILETAVRPDTRLRLGTVLAERSRRLGLTNEDIDALSPARDRTPAEP
MSFE

Nucleotide

• Length: 255 bp

>AT22507 NC_009937:c4389629-4389375 [Azorhizobium caulinodans ORS 571]
ATGCCCGCAGTGACCATCCGCAACCTCTCCGAGGCGACGCACCGTGCCCTCAAGGTGCGCGCGGCCCAGCATGGCCGCAG
CACCGAAGCCGAGATGCGCGACATCCTGGAGACAGCCGTTCGCCCTGACACGCGTCTTCGGCTCGGCACGGTGCTCGCGG
AGCGCAGCCGTCGCCTCGGGCTGACGAATGAGGACATCGACGCCCTCAGCCCGGCGCGTGACAGGACACCTGCCGAGCCC
ATGAGCTTCGAATGA

Structures

Toxin

• AlphaFold DB: A8IP70

Antitoxin

• AlphaFold DB: A8IP74