Detailed information of TA system TA225066

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-CC2985
• Location: 3115284..3115812
• Replicon: chromosome
• Accession: NZ_CP087187
• Organism: Pseudomonas atacamensis strain B21-026

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: LOY41_RS13900
• Protein ID: WP_122706298.1
• Coordinates: 3115522..3115812 (+)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A341F4V9
• Locus tag: LOY41_RS13895
• Protein ID: WP_016770738.1
• Coordinates: 3115284..3115529 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOY41_RS13875 (LOY41_13840)	3110787..3111302	+	516	WP_122706290.1	hypothetical protein	-
LOY41_RS13880 (LOY41_13845)	3111311..3111820	+	510	WP_241089695.1	hypothetical protein	-
LOY41_RS13885 (LOY41_13850)	3112281..3112640	+	360	WP_122706294.1	DUF6124 family protein	-
LOY41_RS13890 (LOY41_13855)	3112875..3114944	+	2070	WP_122706296.1	hypothetical protein	-
LOY41_RS13895 (LOY41_13860)	3115284..3115529	+	246	WP_016770738.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
LOY41_RS13900 (LOY41_13865)	3115522..3115812	+	291	WP_122706298.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOY41_RS13910 (LOY41_13875)	3116013..3117929	-	1917	WP_122706300.1	selenocysteine-specific translation elongation factor	-
LOY41_RS13915 (LOY41_13880)	3117926..3119338	-	1413	WP_110645356.1	L-seryl-tRNA(Sec) selenium transferase	-
LOY41_RS13920 (LOY41_13885)	3119792..3120718	-	927	WP_258717242.1	formate dehydrogenase accessory protein FdhE	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Antitoxin ParD (8-78)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11016.59 Da
• Isoelectric Point: 7.1305

>T225066 WP_122706298.1 NZ_CP087187:3115522-3115812 [Pseudomonas atacamensis]
MAEYRLTPAAVADLEAIWTYTAQQWGLDQANRYIDILTASFEQLADRPKTAPACDAIRPGYRRCSVESHVIYFRITAYGI
AIIRILHDRMEAQRNL

Nucleotide

• Length: 291 bp

>T225066 NZ_CP120944:3409715-3410002 [Escherichia coli O157:H7 str. EDL933]
ATGTTACCCATTTTATGGCTACCGTCTGCTCGCGATGATTTGCGCCAGATCATAACTTACATCGCCAAGGAGAACCCACC
GGCAGCACGTAGACTAAAAATACGCATTGAAACATCGGTATTACCTCTATCTGAGCATCCGTACTTATATCCACCAAGCG
AACGGGTTTCTGGATTGAGAGAGATCGTGACCCACCCTAACTACATAATCCTGTACAGAGTAGCTGCTTCAAGCATTGAG
ATTGTAAGCGTGACACATTCTCGGCGACAATTTCCCTTCTCTATCTGA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 9354.43 Da
• Isoelectric Point: 7.3193

>AT225066 WP_016770738.1 NZ_CP087187:3115284-3115529 [Pseudomonas atacamensis]
MATVRKTITVTDQQDHWIKAQIEAGHYTNDSEYIRDLIRREQERNAELETVRAALREGESSGAPRPFDADAFKKRMLRAH
G

Nucleotide

• Length: 246 bp

>AT225066 NZ_CP120944:3409524-3409715 [Escherichia coli O157:H7 str. EDL933]
ATGGGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCAC
TAAAGTAACGTCAAGCCTTGCAGACACTCGCCCCGCAATTCCACATGACGAGGTAATGGCTGAAATGGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAAGAGCGAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A341F4V9