Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2166952..2167501 Replicon chromosome
Accession NZ_CP087187
Organism Pseudomonas atacamensis strain B21-026

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LOY41_RS09560 Protein ID WP_122707090.1
Coordinates 2167226..2167501 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A554AG13
Locus tag LOY41_RS09555 Protein ID WP_041478584.1
Coordinates 2166952..2167224 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY41_RS09535 (LOY41_09510) 2162260..2162883 + 624 WP_016774080.1 isochorismate family cysteine hydrolase YcaC -
LOY41_RS09540 (LOY41_09515) 2163093..2164520 - 1428 WP_073474277.1 mechanosensitive ion channel family protein -
LOY41_RS09545 (LOY41_09520) 2164629..2165648 - 1020 WP_258717478.1 alpha/beta hydrolase -
LOY41_RS09550 (LOY41_09525) 2165884..2166783 + 900 WP_024012435.1 LysR family transcriptional regulator -
LOY41_RS09555 (LOY41_09530) 2166952..2167224 + 273 WP_041478584.1 ribbon-helix-helix domain-containing protein Antitoxin
LOY41_RS09560 (LOY41_09535) 2167226..2167501 + 276 WP_122707090.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOY41_RS09565 (LOY41_09540) 2167602..2168399 + 798 WP_073474279.1 class I SAM-dependent methyltransferase -
LOY41_RS09570 (LOY41_09545) 2168515..2168823 - 309 WP_110646475.1 putative addiction module antidote protein -
LOY41_RS09575 (LOY41_09550) 2169129..2169821 - 693 WP_056784508.1 hypothetical protein -
LOY41_RS09580 (LOY41_09555) 2169818..2171008 - 1191 WP_122707092.1 GNAT family N-acetyltransferase -
LOY41_RS09585 (LOY41_09560) 2171012..2171701 - 690 WP_073474287.1 N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(10-47)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10688.33 Da        Isoelectric Point: 6.4700

>T225065 WP_122707090.1 NZ_CP087187:2167226-2167501 [Pseudomonas atacamensis]
MELKWTSKGLSDLTRLYEFLAAVNQPAAARTVQQLTAAPIMLLANPRLGESLEEFEPRDVRRILVGHYEMRYEIVDSTIY
LLRLWHTREER

Download         Length: 276 bp

>T225065 NZ_CP120944:2947277-2947384 [Escherichia coli O157:H7 str. EDL933]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10092.46 Da        Isoelectric Point: 5.6994

>AT225065 WP_041478584.1 NZ_CP087187:2166952-2167224 [Pseudomonas atacamensis]
MAAPMKTRSVTAHVPVQLAEKVDLMAERLERSRNWIVKQALSAWIDQEEERSRLTREALADVDAGRVIDHQSVQAWADSL
SSDTPLKAPL

Download         Length: 273 bp

>AT225065 NZ_CP120944:c2947224-2947163 [Escherichia coli O157:H7 str. EDL933]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A554AG13

References