Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1707503..1708119 Replicon chromosome
Accession NZ_CP087187
Organism Pseudomonas atacamensis strain B21-026

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOY41_RS07560 Protein ID WP_101158667.1
Coordinates 1707503..1707715 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID V8RA99
Locus tag LOY41_RS07565 Protein ID WP_016771035.1
Coordinates 1707715..1708119 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY41_RS07535 (LOY41_07515) 1702742..1704730 + 1989 WP_122704698.1 heme lyase CcmF/NrfE family subunit -
LOY41_RS07540 (LOY41_07520) 1704727..1705263 + 537 WP_024012128.1 DsbE family thiol:disulfide interchange protein -
LOY41_RS07545 (LOY41_07525) 1705260..1705730 + 471 WP_016771041.1 cytochrome c-type biogenesis protein CcmH -
LOY41_RS07550 (LOY41_07530) 1705727..1706926 + 1200 WP_122704696.1 c-type cytochrome biogenesis protein CcmI -
LOY41_RS07555 (LOY41_07535) 1706952..1707356 + 405 WP_016771039.1 hypothetical protein -
LOY41_RS07560 (LOY41_07540) 1707503..1707715 + 213 WP_101158667.1 type II toxin-antitoxin system HicA family toxin Toxin
LOY41_RS07565 (LOY41_07545) 1707715..1708119 + 405 WP_016771035.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOY41_RS07570 (LOY41_07550) 1708301..1709488 - 1188 WP_122704692.1 MFS transporter -
LOY41_RS07575 (LOY41_07555) 1709657..1710655 - 999 WP_110601117.1 sulfate ABC transporter substrate-binding protein -
LOY41_RS07580 (LOY41_07560) 1710760..1711584 - 825 WP_016771032.1 ion transporter -
LOY41_RS07585 (LOY41_07565) 1711606..1712520 - 915 WP_122704690.1 urea transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 7908.05 Da        Isoelectric Point: 10.8102

>T225064 WP_101158667.1 NZ_CP087187:1707503-1707715 [Pseudomonas atacamensis]
VQSRLLMKELEEAGWTLDRVAGSHHIFTHRYNPNTIAVPHPKKDLPLGTVKSIRRRAGLFSPATRHEGDP

Download         Length: 213 bp

>T225064 NZ_CP120944:2946741-2946848 [Escherichia coli O157:H7 str. EDL933]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14776.81 Da        Isoelectric Point: 4.5789

>AT225064 WP_016771035.1 NZ_CP087187:1707715-1708119 [Pseudomonas atacamensis]
MQYPICIEWGDENTAIGIQIPDIPGAVTAGDSFEEAYNAAVEVAHLMLQEIAAAGQAIPMPTSAAAHRNHPDFAEMGWGM
LELDISPYLGKTEKVNVTLPGYVIQRIDRYVREHNVKSRSSFLADAAMEKLVRY

Download         Length: 405 bp

>AT225064 NZ_CP120944:c2946693-2946634 [Escherichia coli O157:H7 str. EDL933]
GTCTGGTTTCAAGATTAGCCCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1N7DVA1

References