Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 258841..259484 Replicon chromosome
Accession NZ_CP087187
Organism Pseudomonas atacamensis strain B21-026

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOY41_RS01095 Protein ID WP_110644779.1
Coordinates 258841..259023 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A4Q4LAA7
Locus tag LOY41_RS01100 Protein ID WP_039756416.1
Coordinates 259083..259484 (+) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY41_RS01080 (LOY41_01080) 254051..255049 - 999 WP_122705265.1 D-cysteine desulfhydrase -
LOY41_RS01085 (LOY41_01085) 255240..256166 + 927 WP_122705263.1 serine acetyltransferase -
LOY41_RS01090 (LOY41_01090) 256640..258601 + 1962 WP_160768576.1 choline transporter BetT -
LOY41_RS01095 (LOY41_01095) 258841..259023 + 183 WP_110644779.1 type II toxin-antitoxin system HicA family toxin Toxin
LOY41_RS01100 (LOY41_01100) 259083..259484 + 402 WP_039756416.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOY41_RS01105 (LOY41_01105) 259523..259645 - 123 Protein_213 LacI family transcriptional regulator -
LOY41_RS01110 (LOY41_01110) 260008..261045 + 1038 WP_076565051.1 L-glyceraldehyde 3-phosphate reductase -
LOY41_RS01115 (LOY41_01115) 261175..262017 - 843 WP_122705261.1 taurine dioxygenase -
LOY41_RS01120 (LOY41_01120) 262070..262903 - 834 WP_258717402.1 taurine ABC transporter permease TauC -
LOY41_RS01125 (LOY41_01125) 262900..263694 - 795 WP_122705258.1 taurine ABC transporter ATP-binding subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6934.03 Da        Isoelectric Point: 10.5417

>T225060 WP_110644779.1 NZ_CP087187:258841-259023 [Pseudomonas atacamensis]
MRSREMIRMIEDDGWYLVAVKGSHHQYKHSFKQGRVTIKHPDSDLPKGTINSILKQAGLK

Download         Length: 183 bp

>T225060 NZ_CP120944:2138091-2138194 [Escherichia coli O157:H7 str. EDL933]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14652.46 Da        Isoelectric Point: 4.5860

>AT225060 WP_039756416.1 NZ_CP087187:259083-259484 [Pseudomonas atacamensis]
MKFPVVLHKDADSDYGVIIPDVPGCYSAGATVAEAFENTQEALALHYEGLVADGAPLPQVRDIDAHLDNPDYAGGIWGVV
DFDITPYFGKSVRFNATLPEQLLERIDQTVRRDRRYRSRSGFLAAAALRELSV

Download         Length: 402 bp

>AT225060 NZ_CP120944:c2138232-2137961 [Escherichia coli O157:H7 str. EDL933]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4Q4LAA7

References