Detailed information of TA system TA225048

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 3892175..3892691
• Replicon: chromosome
• Accession: NZ_CP087185
• Organism: Pseudomonas sichuanensis strain B21-027

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LOY51_RS17660
• Protein ID: WP_125464711.1
• Coordinates: 3892175..3892456 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LOY51_RS17665
• Protein ID: WP_125464712.1
• Coordinates: 3892446..3892691 (-)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOY51_RS17640 (LOY51_17615)	3887458..3888273	+	816	WP_258642356.1	protein phosphatase 2C domain-containing protein	-
LOY51_RS17645 (LOY51_17620)	3888410..3889771	+	1362	WP_125859318.1	hypothetical protein	-
LOY51_RS17650 (LOY51_17625)	3889933..3890505	+	573	WP_125859319.1	ComF family protein	-
LOY51_RS17655 (LOY51_17630)	3890596..3891933	-	1338	WP_258642359.1	OprD family porin	-
LOY51_RS17660 (LOY51_17635)	3892175..3892456	-	282	WP_125464711.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOY51_RS17665 (LOY51_17640)	3892446..3892691	-	246	WP_125464712.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
LOY51_RS17670 (LOY51_17645)	3892900..3893361	+	462	WP_189654481.1	PaaI family thioesterase	-
LOY51_RS17675 (LOY51_17650)	3893482..3893805	+	324	WP_258642361.1	DUF2790 domain-containing protein	-
LOY51_RS17680 (LOY51_17655)	3893816..3894544	-	729	WP_258642363.1	hypothetical protein	-
LOY51_RS17685 (LOY51_17660)	3894662..3895408	-	747	WP_125464716.1	sulfite exporter TauE/SafE family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (9-77)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10801.77 Da
• Isoelectric Point: 10.9348

>T225048 WP_125464711.1 NZ_CP087185:c3892456-3892175 [Pseudomonas sichuanensis]
MTYKLEFLPSALKEWEKLGHTVREQAKKKLRERLVLPRVPADALRDLPNHYKIKLKSSGYRLVYRVEDQRVVVLVVAVGK
REGAAAYRSALKR

Nucleotide

• Length: 282 bp

>T225048 NZ_CP120942:c1744673-1744104 [Aeromonas caviae]
ATGAGCTCATATGTCGTCTTACTGGATGCCTGTGTACTCTATCCAGCCCCACTACGTAGTTACTTGATGTACTTGGCTGC
CTCAGGACTGTATCGGGCTCGTTGGACAAACCAGATCCACGAAGAGTGGATAAGCAACCTCCTGTCCAACCGGCCCGACT
TAACTCGTCCACAACTCGAGCGAACTAGGAATCTGATGAATCATCATGCCCCTGATTGCCTGATTGTCGGATATGAACCT
CTGATCGACAGCCTTGATCTGCCTGATGTCGATGACCGCCATGTACTTGCAGCTGCCATCAGAGGGCAAGCGGAAGCAAT
TATTACCTTTAACCTTAAGGACTTTCCAAACGGAACTCTATCTGGTTATGGTATTAGTGCAATTCATCCTGATGAATTTT
TAAGTGACATGCTTGCACTGAGTCCTGGTGAGTGTGTTAAAGCTGCAGCATCACAGCGCGCAGCATTACGAAACCCCACC
ATGAATGCTGACGAATACCTGTTATCGCTACAGCGCCAAGGACTACCTAGATTTGTCAGCGATATGCAGTCATATCGCCT
GATCATCTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8907.37 Da
• Isoelectric Point: 4.6982

>AT225048 WP_125464712.1 NZ_CP087185:c3892691-3892446 [Pseudomonas sichuanensis]
MQNIFADITVSVSELKKNPTAVMAGAQGQPVAVLNHNRVMGYMVPAELYEAMMEQLEDIELAQLVKARAHEKGVPVKLDD
L

Nucleotide

• Length: 246 bp

>AT225048 NZ_CP120942:c1745125-1744673 [Aeromonas caviae]
ATGAACACACTGTCCCACATGCCAAGTGCTGCAGAAGTCGCACTGGCCAAACTCAGTAGCCAAGAACTGGCAGCTTGCCT
GGAGATAAATGGCGAAGGGCAAGAGCTGACTATCCATGATCGCTCAGGGAATGAACGTACGGTAAAAGTGCCGGCTAGCG
CCCTCAATCTGCTCGTTGAAGTGCTGACTCAACTTGGACAAGGTAACATCGTCAAGATCACTCCAATCCATGCGGAGCTG
ACAACTCAACAAGCGGCAGACATGCTGAACATGTCACGGCCAACCATGATCAAAATCCTAGATGAAGGGCAAATCCCTTA
TACTAGAGTGGGAAATCGTCGCAAAGTTGCGTATGCCGAGATTGCCAAGTACAAAGAGGAGCTTTACGCTAACCGGCTGA
ACACCTTGGCTGAGCTGGCTGCACTCGACCAAGAAATGGGTATGGGGTACTGA