Detailed information of TA system TA225045

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 927195..927714
• Replicon: chromosome
• Accession: NZ_CP087185
• Organism: Pseudomonas sichuanensis strain B21-027

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LOY51_RS04325
• Protein ID: WP_258644810.1
• Coordinates: 927195..927485 (-)
• Length: 97 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: LOY51_RS04330
• Protein ID: WP_125462610.1
• Coordinates: 927475..927714 (-)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LOY51_RS04300 (LOY51_04300)	923897..924118	+	222	WP_258644798.1	hypothetical protein	-
LOY51_RS04305 (LOY51_04305)	924188..924858	-	671	Protein_827	hypothetical protein	-
LOY51_RS04310 (LOY51_04310)	924984..926051	+	1068	WP_258644801.1	XRE family transcriptional regulator	-
LOY51_RS04315 (LOY51_04315)	926032..926262	+	231	WP_258644804.1	hypothetical protein	-
LOY51_RS04320 (LOY51_04320)	926302..927075	+	774	WP_258644807.1	carbon-nitrogen hydrolase family protein	-
LOY51_RS04325 (LOY51_04325)	927195..927485	-	291	WP_258644810.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LOY51_RS04330 (LOY51_04330)	927475..927714	-	240	WP_125462610.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LOY51_RS04335 (LOY51_04335)	927817..929304	-	1488	WP_258644812.1	methylenetetrahydrofolate reductase C-terminal domain-containing protein	-
LOY51_RS04340 (LOY51_04340)	929624..930688	+	1065	Protein_834	5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase	-
LOY51_RS04345 (LOY51_04345)	930750..931274	+	525	WP_258644815.1	histidine phosphatase family protein	-
LOY51_RS04350 (LOY51_04350)	931526..932482	-	957	WP_258644818.1	arsenic resistance protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	921786..923036	1250

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-64)

Sequences

Toxin

Protein

• Length: 97 a.a.
• Molecular weight: 11429.22 Da
• Isoelectric Point: 10.0984

>T225045 WP_258644810.1 NZ_CP087185:c927485-927195 [Pseudomonas sichuanensis]
MTYNLEFDARALKEWQKLGDTLRQQFKKKLATILLNPRVEANRLHGFPDCYKIKLRSSGYRLVYQVIDHEVVVFVVSVDK
RERDQVYRKAAERLSE

Nucleotide

• Length: 291 bp

>T225045 NZ_CP120865:c4813-4526 [Roseibium sp. KMA01]
ATGACTGGTTATAAACTGTCTCTAGCTGCACAAGCCGACCTTATCAGTATCGCGCTGTATGGCGATGAACGGCATGGGGT
GGAACAGTCTGACCATTACCGTGATCAACTAAGCGCACATTTTGAAATTTTGGCCAAACAGCCCATGTTGTATCCGGCTG
TTGATCATATCCGACAAGGATATCGACGTAGCTTGTGTGGGGTGCATTCCGTCTACTATCGGATCACAGATCGAGGCGTT
GAAATTATGCGGATAATTGGCAGGCAGGATTTCACGAACGAAGTTTGA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 8992.41 Da
• Isoelectric Point: 4.8011

>AT225045 WP_125462610.1 NZ_CP087185:c927714-927475 [Pseudomonas sichuanensis]
MASINVRIDDDLKVRAYRELEKLGVTPSELMRQALQYVAERGQLPFKPVLLTEDDEALLATVRERLAAPQRVKVTLDDL

Nucleotide

• Length: 240 bp

>AT225045 NZ_CP120865:c5070-4810 [Roseibium sp. KMA01]
ATGTCTATGGTTAAAAAAAGTATTTCGGTCACTGACCAACAGGATGAGTGGATTCGAGCGGAAGTTGCCAAAGGTTATTA
TGGCAATGACAGCGAAGTTATCCGCGCCCTGATCCGTGAACGTCAGTTGCAGCAACAGGAAACGCCTGAGCAAATTGAAG
CCATTCGCGCAAAGCTGATTGAAGCTGAACGCAGTGGATTTGCCGACAAAAGCGTTAAGGAGATTTGGGAAGAAGCGCGC
CAACAAGCGAAGGCTGAATGA