Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 332321..332943 | Replicon | chromosome |
| Accession | NZ_CP087185 | ||
| Organism | Pseudomonas sichuanensis strain B21-027 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LOY51_RS01555 | Protein ID | WP_125857127.1 |
| Coordinates | 332321..332512 (+) | Length | 64 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LOY51_RS01560 | Protein ID | WP_125857128.1 |
| Coordinates | 332530..332943 (+) | Length | 138 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOY51_RS01545 (LOY51_01545) | 329032..330351 | + | 1320 | WP_258644150.1 | OprD family porin | - |
| LOY51_RS01550 (LOY51_01550) | 330382..332052 | - | 1671 | WP_258644151.1 | FMN-binding glutamate synthase family protein | - |
| LOY51_RS01555 (LOY51_01555) | 332321..332512 | + | 192 | WP_125857127.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LOY51_RS01560 (LOY51_01560) | 332530..332943 | + | 414 | WP_125857128.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LOY51_RS01565 (LOY51_01565) | 332971..333690 | - | 720 | WP_125857129.1 | response regulator transcription factor | - |
| LOY51_RS01570 (LOY51_01570) | 333843..334985 | - | 1143 | WP_258644152.1 | copper-containing nitrite reductase | - |
| LOY51_RS01575 (LOY51_01575) | 335161..335376 | + | 216 | WP_125857131.1 | hypothetical protein | - |
| LOY51_RS01585 (LOY51_01585) | 335622..335870 | - | 249 | WP_110992228.1 | hypothetical protein | - |
| LOY51_RS01590 (LOY51_01590) | 336527..336886 | + | 360 | WP_125462244.1 | SMR family transporter | - |
| LOY51_RS01595 (LOY51_01595) | 336880..337197 | + | 318 | WP_232883281.1 | multidrug/spermidine efflux SMR transporter subunit MdtI | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 64 a.a. Molecular weight: 6997.17 Da Isoelectric Point: 11.0104
>T225044 WP_125857127.1 NZ_CP087185:332321-332512 [Pseudomonas sichuanensis]
MNSRVMISVIEADGWYLVRSKGSHHHFKHPHKAGLVTIPHPKKDLLPATAASILRQARIGYAS
MNSRVMISVIEADGWYLVRSKGSHHHFKHPHKAGLVTIPHPKKDLLPATAASILRQARIGYAS
Download Length: 192 bp
>T225044 NZ_CP120863:4111922-4112560 [Roseibium sp. KMA01]
ATGACCGATCAAATCATTCCTGCTGACAAAGCTTCACCTCTTGCCCGGATGGATGCCGACCGACTTTCGGGCCTTCTGTC
ATTTCTCCAGGCCGCAGAGCAACTGAAAGACACGCTGCGGTCAGGCACCACGCGAAAGAAACGACCGGAAAGCACAGCTG
AACACACTTGGCGGCTTGCACTCATGGTGCTTGTTTTCGAGCGCGAGCTTGAAGGGCTCGATCTTCAAAGACTGATAAAA
CTGTGCCTCATCCATGACCTTGGCGAAGCCATTTCCGGAGATGTTCCGGCTCCGTCCCAAAGACAGGATGACGACAGACA
GGAACGGGAAAGGCGCGACTTTGAAACGCTCTGTGCGCCGCTGCCCAAAGACATGCGAGACCATCTTATGGCTCTTTGGT
TGGAATATGCGGCTGCAGAAACCGCAGAGGCTCAGCTGGCCAAGGCTTTCGACAAGCTGGAAACGATGCTCCAGCATCTC
CTGATGCCCCCGGGAGACGTGATCTTTTACGAATTCAATCTCACCTATGGACGTGAACGTACGGATTTTTCTCCGCTGAC
CCGGCAAATACGAGATTTGGTGGACAATGGCACACGACAGATTATGGAGGATCTGCAGAACGCCGCATCCAGGACCTGA
ATGACCGATCAAATCATTCCTGCTGACAAAGCTTCACCTCTTGCCCGGATGGATGCCGACCGACTTTCGGGCCTTCTGTC
ATTTCTCCAGGCCGCAGAGCAACTGAAAGACACGCTGCGGTCAGGCACCACGCGAAAGAAACGACCGGAAAGCACAGCTG
AACACACTTGGCGGCTTGCACTCATGGTGCTTGTTTTCGAGCGCGAGCTTGAAGGGCTCGATCTTCAAAGACTGATAAAA
CTGTGCCTCATCCATGACCTTGGCGAAGCCATTTCCGGAGATGTTCCGGCTCCGTCCCAAAGACAGGATGACGACAGACA
GGAACGGGAAAGGCGCGACTTTGAAACGCTCTGTGCGCCGCTGCCCAAAGACATGCGAGACCATCTTATGGCTCTTTGGT
TGGAATATGCGGCTGCAGAAACCGCAGAGGCTCAGCTGGCCAAGGCTTTCGACAAGCTGGAAACGATGCTCCAGCATCTC
CTGATGCCCCCGGGAGACGTGATCTTTTACGAATTCAATCTCACCTATGGACGTGAACGTACGGATTTTTCTCCGCTGAC
CCGGCAAATACGAGATTTGGTGGACAATGGCACACGACAGATTATGGAGGATCTGCAGAACGCCGCATCCAGGACCTGA
Antitoxin
Download Length: 138 a.a. Molecular weight: 14898.98 Da Isoelectric Point: 4.4314
>AT225044 WP_125857128.1 NZ_CP087185:332530-332943 [Pseudomonas sichuanensis]
MLFPIAILPGDDQHAWGVEVPDIPGCFSAGEDLDDAIAMAREAIEGHLELLAQDGEEIPKASKVSVHAANPDYAGCTWAL
IDIDITRYLGKAEKLNITLPAYLLTRIDAYVKNHPEQKSRSGFLAEAALRILQGDCK
MLFPIAILPGDDQHAWGVEVPDIPGCFSAGEDLDDAIAMAREAIEGHLELLAQDGEEIPKASKVSVHAANPDYAGCTWAL
IDIDITRYLGKAEKLNITLPAYLLTRIDAYVKNHPEQKSRSGFLAEAALRILQGDCK
Download Length: 414 bp
>AT225044 NZ_CP120863:4111361-4111873 [Roseibium sp. KMA01]
GTGCTGAATCGCATCAAGCAGGACGTTCTGGCACACGAGCTGGGTGTTTCCCAAAGCCGCATTTCGCGATGGGAAAGCGG
CCGGTCTCACCCAAACCACAAAGACTGCCTAAGGATTACGACGCTCCTGCGCGCACGCGCGGACAGTGCGGCCGACAATG
CTCTTTTGCATCTGGTGTCCCGGTCGAGCGAGCCCGTTCACCTGGTTTGCGATCTCACACACCGGCTTTTGGCCATGTCG
CCTGCTCGGGAGCGGGAATGGCGCGCGCCTGTCTCGGAGTTTCTCCACCGCCCGCTCTGGCGATTTGCGACCGACGGCAT
CCGCAGTGTTGAGCACCGGTTGGCCGACTTTGGTTGGTTCGAACCGCTCAACGATGACGTTGTTTATTGGACCGAAGCTG
CCGATTTTCCGGAAATGTCCATTCCAGAAAGCCAAATCCGGATTTCAAGGCTTCAGTTGTCAGACGGCAGCTTCGCACGC
CTTGTCAGAGAAGAATCGTCGAGTGCCGCATAA
GTGCTGAATCGCATCAAGCAGGACGTTCTGGCACACGAGCTGGGTGTTTCCCAAAGCCGCATTTCGCGATGGGAAAGCGG
CCGGTCTCACCCAAACCACAAAGACTGCCTAAGGATTACGACGCTCCTGCGCGCACGCGCGGACAGTGCGGCCGACAATG
CTCTTTTGCATCTGGTGTCCCGGTCGAGCGAGCCCGTTCACCTGGTTTGCGATCTCACACACCGGCTTTTGGCCATGTCG
CCTGCTCGGGAGCGGGAATGGCGCGCGCCTGTCTCGGAGTTTCTCCACCGCCCGCTCTGGCGATTTGCGACCGACGGCAT
CCGCAGTGTTGAGCACCGGTTGGCCGACTTTGGTTGGTTCGAACCGCTCAACGATGACGTTGTTTATTGGACCGAAGCTG
CCGATTTTCCGGAAATGTCCATTCCAGAAAGCCAAATCCGGATTTCAAGGCTTCAGTTGTCAGACGGCAGCTTCGCACGC
CTTGTCAGAGAAGAATCGTCGAGTGCCGCATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|