Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicB(antitoxin) |
| Location | 4048380..4049036 | Replicon | chromosome |
| Accession | NZ_CP087183 | ||
| Organism | Pseudomonas putida strain B21-029 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | - |
| Locus tag | LOY24_RS17965 | Protein ID | WP_258653050.1 |
| Coordinates | 4048380..4048562 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | - |
| Locus tag | LOY24_RS17970 | Protein ID | WP_258653052.1 |
| Coordinates | 4048611..4049036 (+) | Length | 142 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOY24_RS17935 (LOY24_17915) | 4043386..4045182 | - | 1797 | WP_258653033.1 | DUF1073 domain-containing protein | - |
| LOY24_RS17940 (LOY24_17920) | 4045182..4046468 | - | 1287 | WP_258653035.1 | terminase large subunit | - |
| LOY24_RS17945 (LOY24_17925) | 4046455..4046916 | - | 462 | WP_258653037.1 | DUF2280 domain-containing protein | - |
| LOY24_RS17950 (LOY24_17930) | 4046948..4047556 | - | 609 | WP_258653039.1 | putative metallopeptidase | - |
| LOY24_RS17955 (LOY24_17935) | 4047604..4047921 | - | 318 | WP_258653047.1 | hypothetical protein | - |
| LOY24_RS17960 (LOY24_17940) | 4047921..4048292 | - | 372 | WP_095064330.1 | chemotaxis protein | - |
| LOY24_RS17965 (LOY24_17945) | 4048380..4048562 | + | 183 | WP_258653050.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| LOY24_RS17970 (LOY24_17950) | 4048611..4049036 | + | 426 | WP_258653052.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| LOY24_RS17975 (LOY24_17955) | 4049193..4049882 | - | 690 | WP_258653054.1 | hypothetical protein | - |
| LOY24_RS17980 (LOY24_17960) | 4049879..4050025 | - | 147 | WP_258653056.1 | hypothetical protein | - |
| LOY24_RS17985 (LOY24_17965) | 4050022..4050624 | - | 603 | WP_258653058.1 | recombination protein NinG | - |
| LOY24_RS17990 (LOY24_17970) | 4050890..4051288 | - | 399 | WP_258653060.1 | recombination protein NinB | - |
| LOY24_RS17995 (LOY24_17975) | 4051285..4051518 | - | 234 | WP_258653068.1 | hypothetical protein | - |
| LOY24_RS18000 (LOY24_17980) | 4051515..4051793 | - | 279 | WP_258653071.1 | hypothetical protein | - |
| LOY24_RS18005 (LOY24_17985) | 4051786..4052088 | - | 303 | WP_258653073.1 | hypothetical protein | - |
| LOY24_RS18010 (LOY24_17990) | 4052088..4052429 | - | 342 | WP_258653075.1 | hypothetical protein | - |
| LOY24_RS18015 (LOY24_17995) | 4052432..4053193 | - | 762 | WP_258653077.1 | replication protein P | - |
| LOY24_RS18020 (LOY24_18000) | 4053190..4053981 | - | 792 | WP_258653079.1 | helix-turn-helix domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 4020562..4070831 | 50269 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6984.06 Da Isoelectric Point: 10.8431
>T225039 WP_258653050.1 NZ_CP087183:4048380-4048562 [Pseudomonas putida]
MKYSEFRRWLEAQGVEFSKSANGSHFKIRYKDRQTIFPSHGSKEIGEGLRKAIIKQLGLK
MKYSEFRRWLEAQGVEFSKSANGSHFKIRYKDRQTIFPSHGSKEIGEGLRKAIIKQLGLK
Download Length: 183 bp
>T225039 NZ_CP120847:c5374004-5373621 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA
Antitoxin
Download Length: 142 a.a. Molecular weight: 15181.35 Da Isoelectric Point: 5.1910
>AT225039 WP_258653052.1 NZ_CP087183:4048611-4049036 [Pseudomonas putida]
MYDYKIVAHEENDHFWSSCPAIPEAHSVGDSLEELLANAVDGITLALSIYVDQKRAIPPATEAGDHIVRLSGVTVAKIAL
WNELVRAGKTRADLASMLGVSPTAAGRLVDFEHTSKLESLEEALAKFGVRLMVTPTAIRAA
MYDYKIVAHEENDHFWSSCPAIPEAHSVGDSLEELLANAVDGITLALSIYVDQKRAIPPATEAGDHIVRLSGVTVAKIAL
WNELVRAGKTRADLASMLGVSPTAAGRLVDFEHTSKLESLEEALAKFGVRLMVTPTAIRAA
Download Length: 426 bp
>AT225039 NZ_CP120847:c5374246-5374004 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|