Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4264687..4265342 Replicon chromosome
Accession NZ_CP087182
Organism Pseudomonas protegens strain B21-030

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOY23_RS19450 Protein ID WP_053159224.1
Coordinates 4264687..4264866 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOY23_RS19455 Protein ID WP_053159226.1
Coordinates 4264917..4265342 (+) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY23_RS19425 (LOY23_19400) 4260978..4261253 + 276 WP_011061856.1 peptidylprolyl isomerase -
LOY23_RS19430 (LOY23_19405) 4261578..4262795 - 1218 WP_019096140.1 amino acid deaminase -
LOY23_RS19435 (LOY23_19410) 4262843..4263607 - 765 WP_011061859.1 IclR family transcriptional regulator -
LOY23_RS19440 (LOY23_19415) 4263741..4264130 - 390 WP_011061860.1 RidA family protein -
LOY23_RS19445 (LOY23_19420) 4264449..4264598 + 150 WP_155494419.1 hypothetical protein -
LOY23_RS19450 (LOY23_19425) 4264687..4264866 + 180 WP_053159224.1 type II toxin-antitoxin system HicA family toxin Toxin
LOY23_RS19455 (LOY23_19430) 4264917..4265342 + 426 WP_053159226.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOY23_RS19460 (LOY23_19435) 4265430..4265975 - 546 WP_053159228.1 hypothetical protein -
LOY23_RS19465 (LOY23_19440) 4266161..4267594 - 1434 WP_019095389.1 RtcB family protein -
LOY23_RS19470 (LOY23_19445) 4268102..4269118 - 1017 WP_258717779.1 fimbrial protein -
LOY23_RS19475 (LOY23_19450) 4269424..4269996 + 573 WP_015636027.1 type 1 glutamine amidotransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6632.67 Da        Isoelectric Point: 11.1475

>T225033 WP_053159224.1 NZ_CP087182:4264687-4264866 [Pseudomonas protegens]
MKFSEFRRWLKAQGVVFEAGKGSHFKVTAPNGNKTTFADHGSKEMPEPTRKAIIRQLGL

Download         Length: 180 bp

>T225033 NZ_CP120847:c2752496-2751174 [Klebsiella pneumoniae]
ATGGCGACGCTTACCACCTGGATGAACAATGTGCGCGTGGGAACCTTAACCCACCAGGCTAACGGGGCGCACAGTTTTCG
CTATGACGAAGAGTGGCTGCGCAGCCCGCGCGCCAGACCGCTCTCCCTCTCACTGCCGCTGCAGTATGGCAATATCACTG
CCGACGCGGTGTATCACTATTTTGATAACCTGCTGCCCGACAGCCCGCAGGTCCGCGACCGGATCGTCAGGCGCTATCAG
GCGCGCTCGAAGCAGCCGTTCGATCTGCTGGCCGAAGTCGGGCGGGATAGCGTAGGGGCGGTGACCCTCCTGCCGCCGGG
GGAAGAGGCGCACCTGGAAGGATTACGCTGGCAGACGCTGGACGAGGCGCAGCTCACCGCTTTGCTGACCGCTTACCAGT
CGGATATCCCCCTCGGGATGATTACCAGCCAGGACGATTTCCGTATCTCGGTGGCCGGCGCCCAGGAGAAAACGGCGCTG
CTGCGGATGGGCGAGCAGTGGTGTATTCCGCAGGGCGCCACGCCGACCACGCATATCATTAAGCTGCCCATCGGCGAGAT
AAAGCAGCCCAATGCGACGCTGGATCTGCGTGAAAGCGTGGATAATGAGTATCTGTGCCTGGCGCTGGCCAGAGAACTGG
GCCTGGCGGTGCCGGAAGCGGAGATCATCACCACTCCGCGGATCCGCGCCCTGGCGGTAACCCGCTTCGACCGGCGCTGG
GCGCAGGAGGGACGGGTGCTGCTGCGTCTGCCGCAGGAGGATCTGTGTCAGGCTTTTGGTCTTCCTTCAGCGATGAAATA
TGAGTCTGACGGCGGGCCGGGTATCGCCGCGATCATGACCTTTCTGCTGGGCTCGAGTGAAGCGCTGAAAGATCGCTATG
ACTTTATGAAGTTCATGGTCTTCCAGTGGCTGACGGGGGCGACGGACGGTCACGCAAAAAACTTCTCAATTTACCTGTTG
CCCGGCGGCAGCTACCGCTTAACACCGTTCTACGACATTATTTCGGCGTTTCCGGTGCTGGGCGGCACGGGACTGCATCT
GCGCGATCTGAAGCTGTCGATGGGGCTCAATGCCACAAAAGGGCGTAAAACAGAGATTAACGCCATCTATCCGCGTCATT
TTCTGGCGACGGCCAAAGCGGTGAACTTTCCCCGGGAGCAGATGCTGGCGATCCTCCAGGAGTTTGCCGGGCATGTGCCG
CAGGCAATCGAAAGCGCTCGCCGGACGCTGCCGGCGGACTTTTCCAGCCACGTCTGGCAGGCCATTACAGAGAACATGCT
GAAGCTGCACGCCCGCCTGCAGCAAGGGCTGCAGGCGCTATAG

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15743.06 Da        Isoelectric Point: 4.7790

>AT225033 WP_053159226.1 NZ_CP087182:4264917-4265342 [Pseudomonas protegens]
MYDYAIRFEQDRAPGVAVFCRDLPELNSFGDDPEHAINQAIDALETTLSLYVDQRRAIPPASEPLPGEQVIHLPMVTVAK
IALWNTMMERDMRKADLCRLLGIHQAQGDRLVDFLHSSKMEQLENALAALGKRLAVSVEAA

Download         Length: 426 bp

>AT225033 NZ_CP120847:c2752762-2752496 [Klebsiella pneumoniae]
ATGAATTCCCCGCAGATATACAGTCCCGTGCAGCTGGCCAATTACCTGAAGCTGCTGCGCCAGCAGAACCACTGGACCCA
GGATGCGCTGGCCAGGCGGATCGGCATTAAGCAGGCCACGCTGTCCAATTTTGAAAATCACCCCGACAAAACCACCTTAA
CCACGCTGTTTAAGATCCTCCAGTCGCTGGGGGTGGTGATGATGCTGAACGCCAAAGCTGCTGAGACGGCGCCGGCTCCC
GATAACAACACGGACCTTGACTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References