Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2507749..2508371 Replicon chromosome
Accession NZ_CP087182
Organism Pseudomonas protegens strain B21-030

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LOY23_RS11495 Protein ID WP_077935001.1
Coordinates 2508189..2508371 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LOY23_RS11490 Protein ID WP_077933771.1
Coordinates 2507749..2508150 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY23_RS11460 (LOY23_11445) 2502793..2504418 + 1626 WP_077933768.1 methyl-accepting chemotaxis protein -
LOY23_RS11465 (LOY23_11450) 2504527..2504961 - 435 WP_258718350.1 hypothetical protein -
LOY23_RS11470 (LOY23_11455) 2504994..2505362 - 369 WP_077933769.1 antibiotic biosynthesis monooxygenase family protein -
LOY23_RS11475 (LOY23_11460) 2505496..2505930 + 435 WP_019094724.1 MarR family winged helix-turn-helix transcriptional regulator -
LOY23_RS11480 (LOY23_11465) 2506175..2506882 - 708 WP_258718351.1 DUF1266 domain-containing protein -
LOY23_RS11485 (LOY23_11470) 2506954..2507226 - 273 WP_227454132.1 DUF5339 family protein -
LOY23_RS11490 (LOY23_11475) 2507749..2508150 - 402 WP_077933771.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LOY23_RS11495 (LOY23_11480) 2508189..2508371 - 183 WP_077935001.1 type II toxin-antitoxin system HicA family toxin Toxin
LOY23_RS11500 (LOY23_11485) 2508514..2509212 - 699 WP_047336258.1 arsenical resistance protein ArsH -
LOY23_RS11505 (LOY23_11490) 2509222..2509692 - 471 WP_152686094.1 arsenate reductase ArsC -
LOY23_RS11510 (LOY23_11495) 2509723..2511006 - 1284 WP_053157447.1 arsenic transporter -
LOY23_RS11515 (LOY23_11500) 2511027..2511374 - 348 WP_169894003.1 metalloregulator ArsR/SmtB family transcription factor -
LOY23_RS11520 (LOY23_11505) 2511605..2512159 + 555 WP_123430367.1 hypothetical protein -
LOY23_RS11525 (LOY23_11510) 2512366..2512797 - 432 WP_011060488.1 carboxymuconolactone decarboxylase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6798.01 Da        Isoelectric Point: 11.5631

>T225031 WP_077935001.1 NZ_CP087182:c2508371-2508189 [Pseudomonas protegens]
VQSRLLIKELEAAGWVLERVTGSHHLFQHPYRPNTVPVPHPKKDLPRGTVRAIRKLAGLL

Download         Length: 183 bp

>T225031 NZ_CP120847:859646-860056 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGACGGATCCATGCCCGTCGCGGGGAAATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14514.49 Da        Isoelectric Point: 5.1222

>AT225031 WP_077933771.1 NZ_CP087182:c2508150-2507749 [Pseudomonas protegens]
VQYPICIEWGDEHTATGIQIPDIPGAVTAGDTFEAAYSAAVEIAHLMLEELARAGQAIPLPSATQTHRAHPDYQGMGWGM
LEIDITPYLGKTEKVNVTLPGYVIQQIDRFVRAHNIKSRSSFLADAALEKLGR

Download         Length: 402 bp

>AT225031 NZ_CP120847:859399-859665 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References