Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 761677..762273 Replicon chromosome
Accession NZ_CP087182
Organism Pseudomonas protegens strain B21-030

Toxin (Protein)


Gene name relE Uniprot ID A0A2C9EFT8
Locus tag LOY23_RS03345 Protein ID WP_015633982.1
Coordinates 761971..762273 (-) Length 101 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4KIY9
Locus tag LOY23_RS03340 Protein ID WP_011059020.1
Coordinates 761677..761967 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY23_RS03320 (LOY23_03320) 757947..760079 - 2133 WP_011059016.1 TonB-dependent copper receptor -
LOY23_RS03325 (LOY23_03325) 760168..760578 - 411 WP_183000714.1 DUF2946 domain-containing protein -
LOY23_RS03330 (LOY23_03330) 760634..761128 - 495 WP_065364905.1 copper chaperone PCu(A)C -
LOY23_RS03335 (LOY23_03335) 761178..761576 - 399 WP_011059019.1 DUF2946 domain-containing protein -
LOY23_RS03340 (LOY23_03340) 761677..761967 - 291 WP_011059020.1 putative addiction module antidote protein Antitoxin
LOY23_RS03345 (LOY23_03345) 761971..762273 - 303 WP_015633982.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOY23_RS03350 (LOY23_03350) 762457..763185 - 729 WP_072452000.1 cobalt-precorrin-6A reductase -
LOY23_RS03355 (LOY23_03355) 763182..764279 - 1098 WP_077933276.1 cobalt-precorrin-5B (C(1))-methyltransferase -
LOY23_RS03360 (LOY23_03360) 764373..765587 - 1215 WP_174395750.1 precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE -
LOY23_RS03365 (LOY23_03365) 765725..767038 + 1314 WP_174395749.1 precorrin-3B synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-95)

Antitoxin

Uncharacterized protein HI1420

(3-94)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11504.34 Da        Isoelectric Point: 10.6512

>T225029 WP_015633982.1 NZ_CP087182:c762273-761971 [Pseudomonas protegens]
MFVFEQTPEFSRWLLNLKDPQGKTRVLARIRAAQLGRFGDCEPVGEGVHEMRIHRGPGYRVYFSRRGKVIYLLLIGGDKA
TQKRDIQRARQLACDLKSEG

Download         Length: 303 bp

>T225029 NZ_CP120847:356620-356988 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10423.94 Da        Isoelectric Point: 5.0939

>AT225029 WP_011059020.1 NZ_CP087182:c761967-761677 [Pseudomonas protegens]
MRTPVTRFDAAEYLKTPEDMVAYLDACFEEDTGDGVLIRAALNDIARARGMTQVARDTGLGRESLYKALGSQGNPEFATI
IKVMKALGLKINVSNA

Download         Length: 291 bp

>AT225029 NZ_CP120847:356402-356623 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9EFT8

Antitoxin

Source ID Structure
AlphaFold DB Q4KIY9

References