Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-DUF971
Location 4389131..4389719 Replicon chromosome
Accession NZ_CP087181
Organism Pseudomonas sp. B21-031

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LOY53_RS19595 Protein ID WP_252825351.1
Coordinates 4389131..4389433 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag LOY53_RS19600 Protein ID WP_027593133.1
Coordinates 4389426..4389719 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY53_RS19570 4385006..4385134 - 129 WP_256214945.1 PA1414 family protein -
LOY53_RS19575 (LOY53_19570) 4385259..4386152 - 894 WP_027593129.1 LysR family transcriptional regulator -
LOY53_RS19580 (LOY53_19575) 4386259..4387440 + 1182 WP_258703156.1 MFS transporter -
LOY53_RS19585 (LOY53_19580) 4387574..4388500 - 927 WP_099430143.1 DMT family transporter -
LOY53_RS19590 (LOY53_19585) 4388606..4389001 - 396 WP_027593132.1 hypothetical protein -
LOY53_RS19595 (LOY53_19590) 4389131..4389433 + 303 WP_252825351.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LOY53_RS19600 (LOY53_19595) 4389426..4389719 + 294 WP_027593133.1 putative addiction module antidote protein Antitoxin
LOY53_RS19605 (LOY53_19600) 4389832..4390104 + 273 WP_099455003.1 hypothetical protein -
LOY53_RS19610 (LOY53_19605) 4390161..4391522 - 1362 WP_027593135.1 DEAD/DEAH box helicase -
LOY53_RS19615 (LOY53_19610) 4391627..4392913 + 1287 WP_099455004.1 mechanosensitive ion channel family protein -
LOY53_RS19620 (LOY53_19615) 4393028..4393963 - 936 WP_252825353.1 AEC family transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4381325..4400391 19066


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(22-87)

Antitoxin

Uncharacterized protein HI1420

(8-93)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11432.12 Da        Isoelectric Point: 10.5383

>T225026 WP_252825351.1 NZ_CP087181:4389131-4389433 [Pseudomonas sp. B21-031]
MKKIESSSFRHWVHGLRDEMARIRIIARINRLMEGLSGDVSAVGHGVSELRIHHGPGYRVYFHQAGDTLVILLCGGDKSS
QRRDIKAAHEILRSWRMQND

Download         Length: 303 bp

>T225026 NZ_CP120838:10762-11067 [Salmonella enterica subsp. enterica]
ATGCAGTTTAAGGTTTACACCTGTAAAAGGGAGAGTCGCTACCGGCTGTTTGTGGACGTGCAGAGCGACATCATTGACAC
CCCCGGACGGCGGATGGCTGTCCCGCTGGTCAGCGCCCGTCTGCTGTCGGAAAAGGTTCCCCGCGATCTTTACCCGGTGA
TGCATATCGGGGATGAGCCTTACCGCCTGCTGACCACGGATATGACCAGTGTGCCGGCCACCGTCATCGGGGAAGAGGTG
GCCGATCTCAGCCTCCGGGAGAACGATATCAAAAACGCCATTAACCTGATGTTCCGGGGGATCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10517.96 Da        Isoelectric Point: 5.5740

>AT225026 WP_027593133.1 NZ_CP087181:4389426-4389719 [Pseudomonas sp. B21-031]
MTETFFEFDAADYLTTPQAIAQFMSDALETGDASYVAKAVGVVARAKGMSDLAKETGLSREQLYRSFSEHGNPTLKSFLA
VMKALGIDMTAKPHLAH

Download         Length: 294 bp

>AT225026 NZ_CP120838:10542-10760 [Salmonella enterica subsp. enterica]
ATGAAGCAGCGAATTACAGTGACAGTGGACAGCGACAGCTATCAGCTGCTCAAGGCATACGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGCCGTCTGCGAGCCGAACGCTGGCAGGAAGAAAATCGGGAAGGTATGGCTG
AGGTGGCCAGCTTTATAGAGGCTAACGGATCGTTTGCTGACGACAACAGGAACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References