Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 1483615..1485308 | Replicon | chromosome |
| Accession | NZ_CP087179 | ||
| Organism | Pseudomonas sp. B21-035 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | A0A1H1EW83 |
| Locus tag | LOY22_RS06835 | Protein ID | WP_045193444.1 |
| Coordinates | 1484439..1485308 (-) | Length | 290 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A1H1EW67 |
| Locus tag | LOY22_RS06830 | Protein ID | WP_045193445.1 |
| Coordinates | 1483615..1484442 (-) | Length | 276 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LOY22_RS06810 (LOY22_06805) | 1478823..1480313 | - | 1491 | WP_258596940.1 | aldehyde dehydrogenase | - |
| LOY22_RS06815 (LOY22_06810) | 1480324..1481127 | - | 804 | WP_045193450.1 | aspartate dehydrogenase | - |
| LOY22_RS06820 (LOY22_06815) | 1481138..1482820 | - | 1683 | WP_093386131.1 | thiamine pyrophosphate-binding protein | - |
| LOY22_RS06825 (LOY22_06820) | 1482813..1483613 | - | 801 | WP_258596944.1 | SDR family oxidoreductase | - |
| LOY22_RS06830 (LOY22_06825) | 1483615..1484442 | - | 828 | WP_045193445.1 | IclR family transcriptional regulator | Antitoxin |
| LOY22_RS06835 (LOY22_06830) | 1484439..1485308 | - | 870 | WP_045193444.1 | alpha/beta fold hydrolase | Toxin |
| LOY22_RS06840 (LOY22_06835) | 1485313..1485852 | - | 540 | WP_093386119.1 | cupin domain-containing protein | - |
| LOY22_RS06845 (LOY22_06840) | 1485867..1486631 | - | 765 | WP_093387658.1 | SDR family oxidoreductase | - |
| LOY22_RS06850 (LOY22_06845) | 1486631..1487407 | - | 777 | WP_045193442.1 | ABC transporter permease | - |
| LOY22_RS06855 (LOY22_06850) | 1487437..1488435 | - | 999 | WP_213602118.1 | ABC transporter substrate-binding protein | - |
| LOY22_RS06860 (LOY22_06855) | 1488475..1489311 | - | 837 | WP_045193440.1 | ABC transporter ATP-binding protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 30726.10 Da Isoelectric Point: 7.2593
>T225022 WP_045193444.1 NZ_CP087179:c1485308-1484439 [Pseudomonas sp. B21-035]
MLHATDHSLAGLAAQLQQRFPQRLVQLASGAQAIREAGHGPAIVLLHGIGSGAASWLQVALQLSQHARVIAWDAPGYGDS
SPLAKPAPQAVDYARRLRHLLDALQIDDCLLVGHSLGALSAAALAQQQPQRVRRLVLISPARGYGDPARAEQAQQVRNQR
LHNLEQLGIAQMANQRSAHMLSPAASSEARAWVQWNMARLLPQGYRQAIELLCGDDLLRYAALAVPCEVHCGAADSITRP
EDCQALAKALGAAFALIAEAGHASPIEQPEAVATLLARALEESLTGTAL
MLHATDHSLAGLAAQLQQRFPQRLVQLASGAQAIREAGHGPAIVLLHGIGSGAASWLQVALQLSQHARVIAWDAPGYGDS
SPLAKPAPQAVDYARRLRHLLDALQIDDCLLVGHSLGALSAAALAQQQPQRVRRLVLISPARGYGDPARAEQAQQVRNQR
LHNLEQLGIAQMANQRSAHMLSPAASSEARAWVQWNMARLLPQGYRQAIELLCGDDLLRYAALAVPCEVHCGAADSITRP
EDCQALAKALGAAFALIAEAGHASPIEQPEAVATLLARALEESLTGTAL
Download Length: 870 bp
>T225022 NZ_CP120837:c4072616-4072332 [Salmonella enterica subsp. enterica]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGCAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGATCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGCTTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGTAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG
Antitoxin
Download Length: 276 a.a. Molecular weight: 30416.81 Da Isoelectric Point: 6.3865
>AT225022 WP_045193445.1 NZ_CP087179:c1484442-1483615 [Pseudomonas sp. B21-035]
MNDSDLLKDNQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLELPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDHLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQHSPCTPKTVLELFDLVQSDRQRGYVSGEGFFESSISTIAAPVRDHSGRVVAAMGVTIPTVQVAHINF
DGLLGHVRGSADELSRLLNYTPNAGSGRVTALMRD
MNDSDLLKDNQDKYIVPGLERGLLLLCEFSRQNRTLTAPELARRLELPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDHLNYPSNLVVRDGRSIVYVAKVSPPSVFSSAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQHSPCTPKTVLELFDLVQSDRQRGYVSGEGFFESSISTIAAPVRDHSGRVVAAMGVTIPTVQVAHINF
DGLLGHVRGSADELSRLLNYTPNAGSGRVTALMRD
Download Length: 828 bp
>AT225022 NZ_CP120837:c4072848-4072606 [Salmonella enterica subsp. enterica]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACCGTCACTCTTAGCGACA
GTGAAGATGCATTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1H1EW83 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1H1EW67 |