Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 624075..624715 Replicon chromosome
Accession NZ_CP087179
Organism Pseudomonas sp. B21-035

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LOY22_RS02770 Protein ID WP_213602580.1
Coordinates 624075..624485 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LOY22_RS02775 Protein ID WP_093387177.1
Coordinates 624485..624715 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOY22_RS02740 (LOY22_02740) 619094..621160 - 2067 WP_093376590.1 TonB-dependent copper receptor -
LOY22_RS02745 (LOY22_02745) 621239..621667 - 429 WP_093376587.1 DUF2946 domain-containing protein -
LOY22_RS02750 (LOY22_02750) 621687..622160 - 474 WP_045196966.1 copper chaperone PCu(A)C -
LOY22_RS02755 (LOY22_02755) 622208..622600 - 393 WP_045196971.1 DUF2946 domain-containing protein -
LOY22_RS02760 (LOY22_02760) 622697..623554 - 858 WP_045196972.1 SPFH domain-containing protein -
LOY22_RS02765 (LOY22_02765) 623578..624015 - 438 WP_045196974.1 NfeD family protein -
LOY22_RS02770 (LOY22_02770) 624075..624485 - 411 WP_213602580.1 tRNA(fMet)-specific endonuclease VapC Toxin
LOY22_RS02775 (LOY22_02775) 624485..624715 - 231 WP_093387177.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LOY22_RS02780 (LOY22_02780) 624808..625521 - 714 WP_258596203.1 cobalt-precorrin-6A reductase -
LOY22_RS02785 (LOY22_02785) 625518..626615 - 1098 WP_093376577.1 cobalt-precorrin-5B (C(1))-methyltransferase -
LOY22_RS02790 (LOY22_02790) 626608..627819 - 1212 WP_093376572.1 precorrin-6y C5,15-methyltransferase (decarboxylating) subunit CbiE -
LOY22_RS02795 (LOY22_02795) 627975..629270 + 1296 WP_256326765.1 precorrin-3B synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15173.57 Da        Isoelectric Point: 7.8763

>T225021 WP_213602580.1 NZ_CP087179:c624485-624075 [Pseudomonas sp. B21-035]
MLKYMLDTNICIFTLKNKPLVVREAFNRHYGQLCISTVTLMELMYGAEKSAAPERNLAVVEGFAARLEVLSYDDRAAAHS
GQLRAELARAGTPIGPYDQMIAGHARSLGLLLVTNNIREFQRVPGLRVEDWLNPAQ

Download         Length: 411 bp

>T225021 NZ_CP120837:c4031515-4031207 [Salmonella enterica subsp. enterica]
ATGCAATACATGGTTTATCGCAATAAAGGAAACAGCAAGGCTTATCCTTATTTACTTGATGTGCAAAGCGATATTATTGA
TGAACTGCATACTCGCATGGTTATCCCATTGTTTCCTGTGAGCAGATTGGTAAATAACCCAGTTAAGCGCCTCACGCCCA
CTCTGAATGTGGAAGGTAATGACTATCTGGTGATGACTCACGAAATGGCGAGTATCAGGCTTTCGCAGATTGGTGATGAG
GTGATGGACGTTCGTTCCCACAGGCAAACCATCAAAAATGCTCTCGATTTTATCTTTGACGGGTTCTGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8583.48 Da        Isoelectric Point: 4.3322

>AT225021 WP_093387177.1 NZ_CP087179:c624715-624485 [Pseudomonas sp. B21-035]
MEQGAVFKSNRSQAVRLPKSVALPEDVKRVDIVAVGRTRIISPSGEAWDSWFEGQDVSPDFMAEREQDTDQEREGF

Download         Length: 231 bp

>AT225021 NZ_CP120837:c4031757-4031518 [Salmonella enterica subsp. enterica]
ATGCCGGGTATGAGTGTACGACATAAAAAAACAGTCAGTGTCACGCTGGAACCTGCATTGCTTCAGCAAGCCCGTGATGC
AGGTATTAATCTGTCAGCGGTGCTTACCGCCGCGCTGAAAGAGGAAATCAGTGCCACAGGCGTTGAACGCTGGAAAGCAG
AAAATAGAGCGGGTTTGCAGGAGCTCAATCGTATTACTGATGAGCACGGCCTTTTATCGGACGATTACAGGACGTTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References